Layer-specific modulation of neocortical dendritic inhibition during active wakefulness
Abstract
Layer-specific interneuron activity: Somatostatin-expressing interneurons are an important group of inhibitory neurons in the brain that target and thus control the dendrites of pyramidal cells. These interneurons have recently been shown to play a role in sensorimotor integration, reinforcement encoding, and selective attention. Muñoz et al. used channelrhodopsin-assisted patching to investigate the spatiotemporal pattern of neocortical dendritic inhibition in vivo. They were able to record the activity of somatostatin-expressing interneurons in all neocortical layers in behaving mice. The results provide a framework for understanding the changes in dendritic inhibition that take place in the neocortex during active behaviors. This framework is very distinct from the view obtained from previous recordings that were restricted to interneurons in the superficial layers of the neocortex. Science , this issue p. 954
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Three previously described morphological types of L5 Pvalb cells, as well as two morphological types of L5 Martinotti cells, corresponded to different t-types.
“We also showed that three previously described morphological types of L5 Pvalb cells5, as well as two morphological types of L5 Martinotti cells29,30, corresponded to different t-types.”
From Phenotypic variation of transcriptomic cell types in mouse motor cortex (2021) · cites this paper as [29]
In the Sst subclass, morpho-electric properties varied continuously across the transcriptomic landscape, with neighbouring t-types consistently showing similar morphologies and similar rebound values.
“We observed the same in the Sst subclass, which is known to be transcriptomically4 and morpho-electrically29,30,33 diverse in L5. Here we also found that morpho-electric properties varied continuously across the transcriptomic landscape, with neighbouring t-types consistently showing similar morphologies and similar rebound values (Fig. 4b).”
From Phenotypic variation of transcriptomic cell types in mouse motor cortex (2021) · cites this paper as [29]
In primary somatosensory cortex (S1), whisker movement is correlated with gain changes that are heterogeneous across subpopulations of cells and across cortical layers.
“In the primary somatosensory cortex (S1), whisker movement is correlated with gain changes that are heterogeneous across subpopulations of cells and across cortical layers40, further highlighting the complexity of gain regulation across circuits.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [40]
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References 61 · Cited by 305
- Authors
- Muñoz, W., Tremblay, R., Levenstein, D., & Rudy, B.
- Affiliations
- New York University (US)
- NYU Langone Health (US)
- Corresponding author
- Muñoz, William
- Tremblay, Robin
- Rudy, Bernardo
- Venue
- Science
- Published
- 2017-03-03
- Volume
- 355
- Issue
- 6328
- Pages
- 954-959
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2593042581
- Cited by
- 305
- References
- 61
- Citations by year
- 2026: 21 · 2025: 29 · 2024: 25 · 2023: 31 · 2022: 26 · 2021: 29 · 2020: 42 · 2019: 39 · 2018: 38 · 2017: 25
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (award291198, R01NS30989,R21NS093987,P01NS074972,F31NS087919)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- dendritic inhibition, GABAergic interneurons, somatostatin interneurons, vasoactive intestinal peptide interneurons, cortical layers, cholinergic modulation, neocortex, pyramidal neurons, synaptic integration, laminar organization
- MeSH terms
- Acetylcholine, Animals, Behavior, Dendrites, Female, gamma-Aminobutyric Acid, Interneurons, Male, Neural Inhibition, Receptors, Muscarinic, Somatostatin, Vasoactive Intestinal Peptide, Wakefulness, Pyramidal Cells, Mice, Knockout, Neocortex, Mice, GABAergic Neurons
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