Multifaceted interactions between adaptive immunity and the central nervous system
Open accessAbstract
Neuroimmunologists seek to understand the interactions between the central nervous system (CNS) and the immune system, both under homeostatic conditions and in diseases. Unanswered questions include those relating to the diversity and specificity of the meningeal T cell repertoire; the routes taken by immune cells that patrol the meninges under healthy conditions and invade the parenchyma during pathology; the opposing effects (beneficial or detrimental) of these cells on CNS function; the role of immune cells after CNS injury; and the evolutionary link between the two systems, resulting in their tight interaction and interdependence. This Review summarizes the current standing of and challenging questions related to interactions between adaptive immunity and the CNS and considers the possible directions in which these aspects of neuroimmunology will be heading over the next decade.
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Meningeal γδ17 T cells substantially express Slc6a13 transcripts.
“Notably, we noticed a substantial expression of Slc6a13 transcripts in meningeal γδ17 T cells (Fig. 2b, Extended Data Fig. 2d), a solute carrier responsible for the gamma-aminobutyric acid (GABA) and taurine transporter (GAT2)10”
From Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons (2020) · cites this paper as [10]
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References 104 · Cited by 376
Research works printed but not linked: 4
- [1]Medawar PB Br J Exp Pathol 29 58 69 1948 18865105 PMC2073079
- [24]Moalem G Nat Med 5 49 55 1999 9883839
- [77]Varga L Piukovich I Zoltán OT Gábor M Földi M Acta Med Acad Sci Hung 22 15 23 1966 5911480
- [90]Rosas-Ballina M Science 334 98 101 2011 21921156 PMC4548937
- Authors
- Kipnis, J.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Kipnis, Jonathan
- ORCID
- Kipnis, Jonathan
- Venue
- Science
- Published
- 2016-08-19
- Volume
- 353
- Issue
- 6301
- Pages
- 766-771
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5590839
- OpenAlex
- W2515274402
- Cited by
- 376
- References
- 104
- Citations by year
- 2026: 34 · 2025: 22 · 2024: 28 · 2023: 23 · 2022: 42 · 2021: 62 · 2020: 53 · 2019: 29 · 2018: 45 · 2017: 33 · 2016: 4
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (AG034113, NS096967)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- neuroimmunology, adaptive immunity, central nervous system, T cell receptor repertoire, immune cell trafficking, central nervous system injury, immune system evolution, neuroimmune interactions
- MeSH terms
- Allergy and Immunology, Central Nervous System, Cognition Disorders, Homeostasis, Humans, Immune System, Immunologic Surveillance, Meninges, Neurology, Adaptive Immunity
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