Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

Myers, Robert W., Guan, Hong-Ping, Ehrhart, Juliann, Petrov, Aleksandr, Prahalada, Srinivasa, Tozzo, Effie, Yang, Xiaodong, Kurtz, Marc M. +41 more·2017·Science
DOI 10.1126/science.aah5582

Cited by (352)

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  13. AMPK activation promotes transcriptional activation of TFEB through its dephosphorylation
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  14. AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification
    LeeAnn A. Hold, Nicole Migotsky, Syeda N. Lamia, Steph S. Steltzer, Sydney Grossman, Jessica A. Chen, Seung-Ho Bae, Paige Cordts, Tessa Phillips, Matthew J. O’Meara et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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  17. GDF6 Alleviates Pathological Cardiac Hypertrophy via AMPKα Signaling Pathway
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  18. Pharmacological activation of AMPK rescues mitophagy defects in models of FBXL4-related mitochondrial DNA depletion syndrome
    Aniketh Bishnu, Robert William Taylor, Kei Sakamoto, Ian G. Ganley · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  19. A Nucleoside Analogue Bearing a C2′-Stereogenic All-Carbon Quaternary Center for the Treatment of Heart Failure
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  21. AMPK Activation by MK-8722 Measured with [18F]FDG-PET Imaging in Rodents and Non-Human Primates
    Daniel J. Rubins, Xiangjun Meng, S. Wang, Hyking Haley, Diane J. Posavec, Mona L. Purcell, Kerry A. Riffel, Robert Walter Myers, Iyassu K. Sebhat, D. E. González Trotter et al. · 2025 · Molecular Imaging and Biology
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  28. Small-molecule kinase activators
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  36. AMPK Therapy—A Little Goes A Long Way
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  37. The dual role of AMPK in cancer metabolic reprogramming
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  39. AMPK as a central node in cancer and cardiovascular diseases
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  42. AMPK Activator MK ‐8722 Improves Spatial Memory Deficit and Alters Metabolome in APP / PS1 AD Mouse Model
    Noelle Isabella Nicol, Tian Li, Qiang Su, Amelia Suhocki, Erin Dunlap, 周雪艳, Hannah M. Jester, Nathaniel A. Swift, Ethan B. Underwood, Jingyun Lee et al. · 2026 · Journal of Neurochemistry
  43. The AMPK signaling pathway in cell metabolism and human diseases
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  44. BindingDB Entry 50001593: Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.
    BindingDB · 2020 · UC San Diego
  45. BindingDB Entry 50017445: The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush.
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  46. BindingDB Entry 50000276: Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
    BindingDB · 2019 · UC San Diego
  47. BindingDB Entry 50014158: Rapid Evaluation of Small Molecule Cellular Target Engagement with a Luminescent Thermal Shift Assay.
    BindingDB · 2022 · UC San Diego
  48. BindingDB Entry 50000315: Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase.
    BindingDB · 2019 · UC San Diego
  49. BindingDB Entry 50002351: Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations.
    BindingDB · 2020 · UC San Diego
  50. BindingDB Entry 50007795: Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators.
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  52. Discovery of 3-Phenyldibenzo[b,d]furan Derivatives as Potent Multi-stage Inhibitors against SARS-CoV-2
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