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Cited by 149Hair Growth and DisordersDevelopmental Biology and Gene Regulationdental development and anomalies

Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision

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Lu, Catherine P., Polak, Lisa, Keyes, Brice E., Fuchs, Elaine·2016·Science
DOI 10.1126/science.aah6102PMC PMC5333576
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Abstract

How to grow hair or sweat glands: Unlike other mammals that must pant or seek shade or water when overheated, humans are able to self-cool to tolerate extreme heat. Sweat glands, which enable humans to run in marathons, are instrumental for this remarkable feat. Lu et al. investigated skin appendage diversity during development of the furry backs and sweaty paws of mice (see the Perspective by Lai and Chuong). They also examined human skin, which is capable of making both hairs and sweat glands in the same area of the body. Epithelialmesenchymal interactions, with varied signaling pathways that act at specific times in development, are key to producing different skin appendages for adaptation to the environment. Science , this issue p. 10.1126/science.aah6102 ; see also p. 1533

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  • SwGs are derived from an epidermal bud of CK5-expressing progenitors, sharing the same origin as epidermal keratinocytes.

    “SwGs are derived from an epidermal bud of CK5‐expressing progenitors,[ 2 , 6 ] sharing the same origin as epidermal keratinocytes that can be readily maintained and propagated in vitro.[ 7 ]”

    From Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin (2021) · cites this paper as [6]

    The ‘Regional differences in BMP pathway genes in skin mesenchymes’ section describes epidermal placodes that develop toward sweat-gland fate, supporting an epidermal-bud origin. The paper’s immunofluorescence methods list a K5 antibody, but the passages do not establish that the buds arise from CK5-expressing progenitors. The statement about epidermal keratinocytes is attached to citation [7], not this source. (LLM, conf=0.83)

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References 53 · Cited by 149

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Authors
Lu, C. P., Polak, L., Keyes, B. E., & Fuchs, E.
Affiliations
  • Rockefeller University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Fuchs, Elaine
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2016-12-23
Volume
354
Issue
6319
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aah6102
PMC
PMC5333576
OpenAlex
W2564889673
Cited by
149
References
53
Citations by year
2026: 9 · 2025: 12 · 2024: 15 · 2023: 17 · 2022: 14 · 2021: 14 · 2020: 24 · 2019: 19 · 2018: 14 · 2017: 9 · 2016: 1
FWCI
20.90
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (K01-AR066073)
  • Robertson Therapeutic Development Fund
  • NIH (R01-AR050452)
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
Keywords
bone morphogenetic proteins, Sonic hedgehog, fibroblast growth factor, eccrine sweat glands
MeSH terms
Animals, Eccrine Glands, Epithelium, Humans, Mesoderm, Morphogenesis, Sweat, Signal Transduction, Hair Follicle, Bone Morphogenetic Proteins, Mice, Hedgehog Proteins, Wnt Signaling Pathway

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