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Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
Open accessAbstract
Bringing carbon-silicon bonds to life: Organic compounds containing silicon are important for a number of applications, from polymers to semiconductors. The catalysts used for creating carbon-silicon bonds, however, often require expensive trace metals or have limited lifetimes. Borrowing from the ability of some metallo-enzymes to catalyze other rare carbene insertion reactions, Kan et al. used heme proteins to form carbon-silicon bonds across a range of conditions and substrates (see the Perspective by Klare and Oestreich). Directed evolution experiments using cytochrome c from Rhodothermus marinus improved the reaction to be 15 times more efficient than industrial catalysts. Science , this issue p. 1048 ; see also p. 970
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Ding, W., Nakai, K., & Gong, H. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac102 · Cited by 66
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Adams, F. C. (2019) · Physics Reports · doi:10.1016/j.physrep.2019.02.001 · Cited by 62
Metadata
- Authors
- Kan, S. B. J., Lewis, R. D., Chen, K., & Arnold, F. H.
- Venue
- Science
- Published
- 2016-11-25
- Volume
- 354
- Issue
- 6315
- Pages
- 1048-1051
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2554528613
- Cited by
- 579
- References
- 0
- FWCI
- 33.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Kan, S. B. J., Lewis, R. D., Chen, K., & Arnold, F. H. (2016). Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life. Science. https://doi.org/10.1126/science.aah6219
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