Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice
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Vitamin B 3 protects mice from glaucoma: Glaucoma is the most common cause of age-related blindness in the United States. There is currently no cure, and once vision is lost, the condition is irreversible. Williams et al. now report that vitamin B 3 (also known as niacin) prevents eye degeneration in glaucoma-prone mice (see the Perspective by Crowston and Trounce). Supplementing the diets of young mice with vitamin B 3 averted early signs of glaucoma. Vitamin B 3 also halted further glaucoma development in aged mice that already showed signs of the disease. Thus, healthy intake of vitamin B 3 may protect eyesight. Science , this issue p. 756 ; see also p. 688
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Recent work has strongly implicated energy deficits in glaucoma.
“Recent work has strongly implicated energy deficits in glaucoma [18–23], and reduced AMPK correlates with anti-inflammatory responses and RGC protection [24].”
From AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma (2021) · cites this paper as [23]
In glaucoma, NAD+ depletion and mitochondrial abnormalities have been shown, and NAM treatment has beneficial effects in mouse models.
“NAD+ depletion and mitochondrial abnormalities have been shown, and beneficial effects of NAM treatment of mouse models have been reported”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Williams et al., 2017
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References 39 · Cited by 617
- Authors
- Williams, P. A., Harder, J. M., Foxworth, N. E., Cochran, K. E., Philip, V. M., Porciatti, V., Smithies, O., & John, S. W. M.
- Affiliations
- Jackson Laboratory (US)
- University of Miami (US)
- University of North Carolina at Chapel Hill (US)
- Tufts University (US)
- Corresponding author
- John, Simon W. M.
- ORCID
- Venue
- Science
- Published
- 2017-02-17
- Volume
- 355
- Issue
- 6326
- Pages
- 756-760
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5408298
- OpenAlex
- W2588300742
- Cited by
- 617
- References
- 39
- Citations by year
- 2026: 71 · 2025: 71 · 2024: 74 · 2023: 75 · 2022: 76 · 2021: 63 · 2020: 77 · 2019: 41 · 2018: 50 · 2017: 19
- FWCI
- 49.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (award292706)
- National Eye Institute (award292707)
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- nicotinic acid, glaucoma, mitochondrial vulnerability, eye degeneration, dietary supplementation, aging, neuroprotection
- MeSH terms
- Aging, Animals, Glaucoma, Mitochondria, NAD, Neurons, Niacinamide, Nicotinamide-Nucleotide Adenylyltransferase, Retinal Ganglion Cells, Genetic Therapy, Cellular Senescence, Neurodegenerative Diseases, Mice
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