Cited by 208Pain Management and Placebo EffectPain Mechanisms and TreatmentsPain Management and Treatment

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Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia

Tinnermann, A., Geuter, S., Sprenger, C., Finsterbusch, J., Büchel, C.·2017·Science

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Abstract

Price modulates early pain processing: Patients in randomized clinical trials frequently stop taking their drug, complaining of side effects. However, it turns out that some of these subjects are part of the placebo group and thus never received any active medication. This is a case of the nocebo effect seriously interfering with medical treatment. Tinnermann et al. investigated whether value information such as the price of a medication can further modulate behavioral nocebo effects and the underlying neural network dynamics (see the Perspective by Colloca). They used brain imaging to characterize the circuits involved in nocebo hyperalgesia within the descending pain pathway from the prefrontal cortex to the spinal cord. Their findings revealed how value information increased the nocebo effect. Science , this issue p. 105 ; see also p. 44

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Authors: Tinnermann, A., Geuter, S., Sprenger, C., Finsterbusch, J., & Büchel, C.
Affiliations: University Medical Center Hamburg-Eppendorf (DE)
University of Colorado Boulder (US)
University of Cambridge (GB)
Corresponding author: Tinnermann, A.
ORCID: Tinnermann, A.
Geuter, S.
Sprenger, C.
Finsterbusch, J.
Büchel, C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2017-10-06
Volume: 358
Issue: 6359
Pages: 105-108
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aan1221
OpenAlex: W2763143648
Cited by: 208
References: 54
Citations by year: 2026: 13 · 2025: 28 · 2024: 13 · 2023: 23 · 2022: 22 · 2021: 41 · 2020: 18 · 2019: 23 · 2018: 24 · 2017: 3
FWCI: 10.68
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: European Research Council (award313542, ERC-2010-AdG_20100407)
Deutsche Forschungsgemeinschaft (award313541, SFB936/A06, award343338, GE 2774/1-1)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: nocebo hyperalgesia, drug value, price labeling, prefrontal cortex, brainstem, spinal cord, neuronal interactions, pain processing, placebo effect, expectations
MeSH terms: Adult, Brain Stem, Pharmaceutical Preparations, Female, Humans, Hyperalgesia, Male, Pain Measurement, Placebos, Spinal Cord, Prefrontal Cortex, Young Adult, Pain Perception, Functional Neuroimaging, Skin Cream, Drug-Related Side Effects and Adverse Reactions, Nocebo Effect

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Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia

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