CX3CR1 + mononuclear phagocytes control immunity to intestinal fungi
Open accessAbstract
Phagocytes patrol intestinal fungi Maintaining a healthy balance of gut bacteria can promote good health. Leonardi et al. show that fungi can also interact with gut immune cells to maintain intestinal well-being. CX3CR1 + mononuclear phagocytes (MNPs) patrol the intestine and promote antifungal immunity. Genetic deletion of CX3CR1 in MNPs caused colitis-like symptoms in mice. CX3CR1 polymorphisms were detected in Crohn's disease patients that were unable to produce antibodies against multiple fungal species. Thus, commensal fungi may be as important as bacteria in maintaining gut health, and antifungal therapy could hold promise for treating intestinal inflammation. Science , this issue p. 232
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Intestinal fungi are an important component of host-microbe interactions relevant to immune homeostasis and inflammatory disorders.
“Also neglected to date is the gut mycobiome, and there are indications that our intestinal fungi are an important component of host-microbe interactions of relevance to immune homeostasis and inflammatory disorders (Leonardi et al., 2018) and stress-related disorders such as irritable bowel syndrome (Botschuijver et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Leonardi et al., 2018
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References 54 · Cited by 289
- Authors
- Leonardi, I., Li, X., Semon, A., Li, D., Doron, I., Putzel, G., Bar, A., Prieto, D., Rescigno, M., McGovern, D. P. B., Pla, J., & Iliev, I. D.
- Affiliations
- Weill Cornell Medicine (US)
- Cedars-Sinai Medical Center (US)
- Universidad Complutense de Madrid (ES)
- Department of Experimental Oncology, European Institute of Oncology, I-20141 Milan, Italy.
- Faculty of Pharmacy, Department of Microbiology II, Universidad Complutense de Madrid, 28040 Madrid, Spain.
- Corresponding author
- Iliev, Iliyan D.
- ORCID
- Venue
- Science
- Published
- 2018-01-12
- Volume
- 359
- Issue
- 6372
- Pages
- 232-236
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5805464
- OpenAlex
- W2783354803
- Cited by
- 289
- References
- 54
- Citations by year
- 2026: 24 · 2025: 23 · 2024: 28 · 2023: 36 · 2022: 41 · 2021: 49 · 2020: 38 · 2019: 32 · 2018: 18
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Office of the Director (DK113136, DK098310, AI123819, DK046763, DK062413, DK108140)
- Leona M. and Harry B. Helmsley Charitable Trust
- Kenneth Rainin Foundation (Innovator and Breakthrough awards)
- Swiss National Science Foundation (P2ZHP3_164850)
- AIRC (IG 17628)
- MINECO (BIO2015-64777-P)
- INFECT-ERANET (PCIN-2014-052)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- CX3CR1, mononuclear phagocytes, intestinal fungi, antifungal immunity, commensal fungi, gut microbiota, colitis, Crohn's disease, intestinal inflammation
- MeSH terms
- Gastrointestinal Microbiome, Mycobiome, CX3C Chemokine Receptor 1, Animals, Antibodies, Fungal, Candida albicans, Colitis, Crohn Disease, Dendritic Cells, Humans, Immunoglobulin G, Intestines, Phagocytes, Immunity, Mucosal, Mutation, Missense, T-Lymphocytes, Regulatory, Mice, Th17 Cells
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