A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

Pan, Deng, Kobayashi, Aya, Jiang, Peng, Ferrari de Andrade, Lucas, Tay, Rong En, Luoma, Adrienne M., Tsoucas, Daphne, Qiu, Xintao, Lim, Klothilda, Rao, Prakash, Long, Henry W., Yuan, Guo-Cheng, Doench, John, Brown, Myles, Liu, X. Shirley, Wucherpfennig, Kai W.·2018·Science

DOI 10.1126/science.aao1710

Cited by (857)

Items 701–800 of 857

Scalable multimodal mapping of macrophage regulatory architecture by integrating optical and transcriptomic pooled screens
Takamasa Kudo, Romain Lopez, Ana M. Meireles, Antonio Rios, Paula Pinto Coelho, Vineethkrishna Chandrasekar, Dylan C. Lam, Jan-Christian Huetter, Mineto Ota, Orit Rozenblatt–Rosen et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Resistance to immune checkpoint inhibitors in the treatment of metastatic renal cancer
Адель Альбертович Измайлов, Рахимов Радмир Радимович, A. V. Sultanbayev, Константин Викторович Меньшиков, I. R. Gilyazova, V. M. Zabelin, A. A. Izmailov · 2023 · Siberian Journal of Oncology
CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Ziye Song, Youkyung Lim, Anneloes van Krimpen, Mitchell A.A. Geleijnse, Manon Messchendorp, Jane S.A. Voerman, Ling Vicky Li, Emma G.M. Tondeur, Gunja Mishra, Brett J. Hos et al. · 2025 · Cancer Immunology Research
PD‐L1 Expression is Mediated by microRNA Processing, Wnt/β‐Catenin Signaling, and Chemotherapy in Wilms Tumor
Patricia D.B. Tiburcio, Kavita K. Desai, Austin Warne, Arash Nabbi, Serena Zhou, Sean D. Reiff, Matthew E. Campbell, James F. Amatruda, Kenneth Sung-Man Chen · 2025 · Pediatric Blood & Cancer
RBCK1 enhances antiviral response through promoting K63-linked polyubiquitination of IRF7 in Carassius auratus var. Pengze
Quanling Zhang, Tingting Yu, Zhongwei Wang, Miaomiao Li, Jingen Xu, Xuefeng Liu, Cheng Qian, Zijia Yin, Gang He, Menglei Hu et al. · 2025 · Fish & Shellfish Immunology
UBE2N as a novel prognostic and therapeutic biomarker of lung adenocarcinoma
Haofeng Yin, Yibo Xue, Chen Wang, Yanqin Wu, Yuchen Guo, Chunzhen Li, Yunyan Zhang, Shulei Yin, Tiejun Zhao · 2025 · Frontiers in Immunology
ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes
Hefei Wang, Fangting Zhao, Yao Li, Peiyu Wang, Yixue Wang, Pengfei Ren, Changhe Li, Hanqiu Zheng, Zexian Zeng, Deng Pan · 2025 · Cancer Research
Multi-omics analysis reveals ultraviolet response insights for immunotherapy and prognosis
Danhua Zhang, Mei Dai, Jiafei Ying, Yifan Huang, Zixuan Liu, ChenLu Wu · 2025 · Frontiers in Immunology
Comparative Characterization of Tumor Microenvironments in Monophasic and Biphasic Synovial Sarcomas
Anna Mikhailovna Kosyreva, Enar D. Jumaniyazova, Alexandra Vladislavovna Sentyabreva, Ekaterina Alexandrovna Miroshnichenko, Dzhuliia Sh. Dzhalilova, Timur I. Fetisov, Anastasia Alekseevna Tararykova, А. V. Lokhonina, Timur Fatkhudinov · 2025 · International Journal of Molecular Sciences
PBRM1-dependent PBAF targeting is required for EMT and metastasis in breast cancer
Alisha Dhiman, Mitchell G. Ayers, Jamie L McCuiston, Aparna B. Shinde, Saeed Salehin Akhand, Guanming Jiao, Juan P P Jauregui-Lozano, Marco Hadisurya, Elizabeth G. Poulsen Porter, W. Andy Tao et al. · 2026 · Science Advances
Intersection of Black race and carbohydrate antigen 19‐9 nonproduction underpins worse pathologic response to neoadjuvant therapy in pancreatic cancer
Mary P Martos, Erin M. Dickey, Kawther Abdilleh, Syed Ameen Ahmad, Shishir Kumar Maithel, Natasha Leigh‐Matijakovich, Hong Jin Kim, Daniel Erik Abbott, Syed Nabeel Zafar, David A. Kooby et al. · 2025 · Cancer
Unveiling macrophage-fibroblast-driven inflammatory networks mediated pan-cancer immune features by integrated single-cell and bulk RNA sequencing
Yi Liu, Jing Li, Liang Xu, Hong-Fang Liu, Congting Wu, Shige Shan, Wei J. Gong · 2025 · International Journal of Surgery
Large-scale CRISPR-Cas9 screens to define regulators of immune checkpoints
Michael Mu, Johannes C. Melms, Patricia Ho, Benjamin Izar · 2025 · Methods in cell biology
Механизмы резистентности к иммунотерапии при MSI фенотипе
М. Ю. Федянин · 2025 · Malignant tumours
The fall of the genome protectors triad: PBRM1, SETD2, and BAP1’s impact on metabolism and immunity in clear cell renal cell carcinoma
Mathieu Johnson, Sandra Turcotte · 2026 · Frontiers in Cell and Developmental Biology
CUL5 E3 ubiquitin ligase regulates the evasion of bladder cancer cells to CD8+ T cell-mediated killing by inhibiting autophagy
Xincheng Gao, Yanchao Yu, Jiayin Sun, Huayuan Zhao, Yongqiang You, Xin Shi, Kang Wang, Sijia Hong, Xing Xiong, Chao Huang et al. · 2026 · PLoS Biology
PROTAC-based protein degradation: a window of opportunity for melanoma therapy
Giulia Gentile, Simona D’Aguanno, Marta Di Martile, Adele Petricca, Elisabetta Valentini, Stefano Scalera, Donatella Del Bufalo · 2026 · Journal of Biomedical Science
NECSO-based classification predicts immunotherapy efficacy and identifies FLAD1 as therapeutic target in kidney renal clear cell carcinoma
Yitong Pan, Rui Wu, Xueyi Zhu, Xiaodi Hu, Jun Cheng, Lingwen Kong · 2026 · Frontiers in Immunology
Research Progress of the Treatment of PD-1 Immune CheckpointInhibitors in Oral Squamous Cell Carcinoma
Ye-Tao Wang, Suying Qian, Kesang Li · 2020 · Journal of Oncology Research
Multiple primary malignancies with complex genomic profiling
Sanjay Hinduja, Omar Mahmood, Adnan Ahmed Khan, Yuankai Lin · 2022 · Current Problems in Cancer Case Reports
T Cell-Mediated Tumor Killing-Related Classification of the Immune Microenvironment and Prognosis Prediction of Lung Adenocarcinoma
Peng Ding, Lichao Liu, Yawen Bin, Yü Huang, Lingjuan Chen, Lu Wen, Ruiguang Zhang, Fan Tong, Xiaorong Dong · 2022 · Journal of Clinical Medicine
Dissecting MENIN in bivalent gene regulation
Xue Qing David Wang, Yali Dou · 2023 · Nature Cell Biology
Targeting of the SWI/SNF chromatin remodeling complex in cancer therapy
Marina V. Nemtsova, Irina Vladimirovna Bure · 2023 · Advances in molecular oncology
Bulk anda single-cell transcriptome profiling reveals the molecular characteristics of T cell-mediated tumor killing in pancreatic cancer
Yinwei Dai, Ya-ting Pan, Danfeng Lin, Xiaohu Chen, Xiang Zhou, Wei‐Ming Wang · 2024 · Heliyon
The Evolving Landscape of Biomarkers for Immune Checkpoint Blockade in Genitourinary Cancers
Seema Mustafa, Caroline Stewart Jansen, Yash C. Jani, Sean Evans, Tony Zhuang, Jacqueline Theresa Brown, Bassel Nazha, Viraj A. Master, Mehmet Asım Bilen · 2024 · Biomarker Insights
First description of a primary SMARCA4-deficient carcinoma of the salivary glands
David Oestreicher, Irina Kostyuchek, Philipp Ströbel, Dirk Beutner, Tobias Dombrowski · 2024 · Human Pathology Reports
The T cell-mediated tumor killing patterns revealed tumor heterogeneous and proposed treatment recommendation in ovary cancer
Xinglin Wen, Beining Yin, Li Lin, Long Liu, Siyuan Weng, Hui Xu, Yuyuan Zhang, Jinhai Deng, Ruiying Liao, Cungeng Fan · 2024 · Discover Oncology
Rapid advancement in cancer genomic big data in the pursuit of precision oncology
Tiara Bunga Mayang Permata, Sri Mutya Sekarutami, Endang Nuryadi, Angela Giselvania, Soehartati Argadikoesoema Gondhowiardjo · 2021 · Medical Journal of Indonesia
Response to systemic therapy in locally advanced and metastatic renal cell carcinoma: can it be predicted?
Javier González, Jeffrey J. Gaynor, Gaetano Ciancio · 2021 · Expert Review of Anticancer Therapy
A novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients
Zesi Liu, Hongxia Yang, Ziyu Chen, Chunli Jing · 2022 · Hereditas
Precision medicine in immunotherapy and lung cancer
Montse Sánchez‐Céspedes · 2023 · Anales de la Real Academia Nacional de Farmacia
PBRM1 regulates the stress response in epithelial cells
Elizabeth G. Poulsen Porter, Alisha Dhiman, Basudev Chowdhury, Benjamin C. Carter, Hang Lin, Jane C. Stewart, Majid Kazemian, Michael K. Wendt, Emily C. Dykhuizen · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptome
Joo Sang Lee, Nishanth Ulhas Nair, Lesley M. Chapman, Sanju Sinha, Kun Wang, Houngui Cha, Eitan Rubin, Raanan Berger, Vladimir Lazar, Razelle Kurzrock et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
A computational network approach to identify predictive biomarkers and therapeutic combinations for anti-PD-1 immunotherapy in cancer
Chia-Chin Wu, Yanru Wang, John Andrew Livingston, Jianhua Zhang, P. Andrew Futreal · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Chameleon microRNAs in breast cancer: their elusive role as regulatory factors in cancer progression
Cesare Miglioli, Gaetan Bakalli, Samuel Orso, Mucyo Karemera, Roberto Molinari, Stéphane Guerrier, Nabil Mili · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
POLR2A Drives Tumor Cell Aggressive in Both VHL and PBRM1 Mutation Renal-Cell Carcinoma
Linyan Chai, Zhengguo Qiu, Xiaozhi Zhang, Rong Li, Yao Wang, Kefeng Wang · 2021 · Research Square
Cohesin mutation sensitizes cancer cells to anti-PD-1 therapy through endogenous retrovirus-mediated PD-L1 upregulation
Yumin Han, Fangfei Peng, Yunqi Chang, Tingting Liu, Jiayan Shen, Zizhuo Chen, Qian Dong, Ping Zhou, Feng Jiang, Honggang Xiang et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy
Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Cindy J. Lee, Ning Yang, Yi Wang et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Transplantable Syngeneic Murine Tumor Models
Rich Woessner, Alexandra Borodovsky, Kris F. Sachsenmeier, Felix Scheuplein, Robert W. Wilkinson, Chaoyang Ye, Simon J. Dovedi · 2022 · Wiley eBooks
TRAF3 Suppression Encourages B Cell Recruitment and Prolongs Survival of Microbiome-Intact Mice with Ovarian Cancer
Jonathan Zorea, Yair Motro, Roei David Mazor, Yifat Koren Carmi, Ziv Shulman, Jamal A. Mahajna, Jacob Moran‐Gilad, Moshe Elkabets · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Data from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers
Di Wang, Jianchao Wang, Dongmei Zhou, Zhixian Wu, Wei Liu, Yanping Chen, Gang Chen, Jing Zhang · 2023
Malaria-derived hemozoin alters chromatin remodelling and skews dendritic cell responses to subsequent bacterial infections
Gintare Lasaviciute, Kanwal Tariq, Anaswara Sugathan, Jaclyn E. Quin, Ioana Bujila, Oleksii A. Skorokhod, Marita Troye‐Blomberg, Eva Sverremark‐Ekström, Ann‐Kristin Östlund Farrants · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Evolutionary trajectories of immune escape across cancers
Wenjie Chen, Toby M. Baker, Zhihui Zhang, Huw A. Ogilvie, Peter Van Loo, Shengqing Stan Gu · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
RNF19B confers tumor resistance to CAR T cells
Roger Geiger, Ian A. Vogel, Andrea Casagranda, Margherita Cattaneo, Luciano Gastón Morosi, Matteo Pecoraro, Einar Sulheim, Camilla Basso · 2025 · Research Square
Poly Combs the Immune System: PRC2 Loss in Malignant Peripheral Nerve Sheath Tumors Can Dampen Immune Responses
Siva Kumar Natarajan, Sriram Venneti · 2019 · Cancer Research
A reversible KO model reveals therapeutic potentials of defective Tregs
Yongqin Li, Tian Chi · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Genome-wide profiling of druggable active tumor defense mechanisms to enhance cancer immunotherapy
Rigel J. Kishton, Shashank J. Patel, Suman Kumar Vodnala, Amy E. Decker, Yogin K. Patel, Madhusudhanan Sukumar, Tori N. Yamamoto, Zhiya Yu, Michelle Ji, Amanda N. Henning et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Mi-2β-targeted inhibition induces immunotherapy response in melanoma
Bo Zhu, Zhengyu Wang, Licheng Yao, Xingyu Lin, Jie Zhang, Xin Li, James R. Hagman, Jingwei Shao, Phuc Tran, Meng Cao et al. · 2020 · Research Square
PBRM1 Regulates the Stress Response in Epithelial Cells
Elizabeth G. Poulsen Porter, Alisha Dhiman, Basudev Chowdhury, Benjamin C. Carter, Hang Lin, Jane C. Stewart, Majid Kazemian, Michael K. Wendt, Emily C. Dykhuizen · 2018 · SSRN Electronic Journal
In vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target
Xiaoqing Wang, Collin J. Tokheim, Binbin Wang, Shengqing Stan Gu, Qin Tang, Yihao Li, Nicole C. Traugh, Yi Zhang, Ziyi Li, Boning Zhang et al. · 2020 · SSRN Electronic Journal
Effects of HMGA2 on the Epithelial-Mesenchymal Transition-Related Genes in ACHN Renal Cell Carcinoma Cells-Derived Xenografts in Nude Mice
Guangyao Lv, Lingling Song, Guanyu Gong, Qian Chen, Kai Li, Xianfeng Liu, Yan Ding, Ying Liu · 2020
Overcoming immune checkpoint inhibitors resistance using oncolytic viruses in melanoma
Tan Trieu Nguyen · 2020
Immune checkpoint blockade therapy in high-grade glioma
Jessica Waibl Polania, Selena Lorrey, Daniel S. Wilkinson, Peter Edward Fecci · 2021 · Elsevier eBooks
Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha
Avinash D Sahu, Xiaoman Wang, Phillip B. Munson, Jan P.G. Klomp, Xiaoqing Wang, Shengqing Stan Gu, Gege Qian, Phillip B. Nicol, Zexian Zeng, Chenfei Wang et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Brisbane River Expressways as Landscape Urbanism
Glenn S. Thomas · 2001
State-of-the-Art and Future Role of Molecular Biomarkers for Patient Selection
Tuomas Jalanko, Mathieu Roumiguié, Peter C. Black · 2022 · Springer eBooks
PBRM1 BD2 and BD4 associate with RNA to facilitate chromatin association
Saumya M. De Silva, Surbhi Sood, Alisha Dhiman, Kilsia F. Mercedes, Morkos A. Henen, Beat Vögeli, Emily C. Dykhuizen, Catherine A. Musselman · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Charakterisierung des NF-κB Signalwegs in Arid1a defizienten Pankreaskarzinomsubtypen
Lena Aperdannier · 2021
Advances in the Treatment of Renal Cell Carcinoma
Paul Reynolds, Grant Duncan Stewart · 2022 · MDPI eBooks
Immunogenomics: a potential approach for precision medicine
Tahir Hussain, Iram Shabir · 2022 · Elsevier eBooks
Faculty Opinions recommendation of SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.
Yves G. Pommier · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors.
Wafik S. El‐Deiry, Philip H. Abbosh · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade.
Paul Nghiem, Thomas Pulliam, Jung‐Hyun Lee · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Modeling Resistance to Immune Checkpoint Blockade
Michael M. Quigley, Matthew J. Meyer, Kanstantsin V. Katlinski · 2022 · Wiley eBooks
Genetic and Immunological Characterization of Advanced NSCLC with SWItch/Sucrose NonFermentable Families Genetic Alterations and Its Impact on Response to Immune Checkpoint Inhibitors
Lanlan Pang, Weitao Zhuang, Fei Pang, Lijuan Chen, Jun Liao, Yihua Huang, Tianqin Mao, Ruonan Pei, Yi Lv, Zhaodi Yuan et al. · 2022 · Research Square
Checkpoint Blockade in Hematologic Malignancies
Andriani Charalambous, Mark‐Alexander Schwarzbich · 2022 · Springer eBooks
Attenuated APC contributes to FGF12 expression and EC progression with an integrated multi-omics analysis
Yunfeng Song, Cheng Zhong, Xiang Feng Hu, Jian Jun Huang, Yiding Bian, Qizhi He, Yiran Li · 2023 · Research Square
YAP-controlled MHC-I and CXCL10 expression potentiates antitumor immunity independently of IFNγ signaling
Linyuan Peng, Liang Zhou, Huan Li, Desheng Lu, Minxian Qian, Zhongyuan Wang · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Immunotherapy for Primary Cancers of Central Nervous System
Seyed Farzad Maroufi, Esmaeil Mohammadi, Mohamad Namvar, Arad Iranmehr, Nima Rezaei, Sara Hanaei · 2023 · Springer eBooks
Data from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer
Roman M. Chabanon, Daphné Morel, Thomas Eychenne, Leo Colmet Daage, Ilirjana Bajrami, Nicolas Dorvault, Marlène Garrido, Cornelia Meisenberg, Andrew E. Lamb, C. Duong-Ngo et al. · 2023
Data from Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer
Kimberly R. Hagel, Rand Arafeh, Sydney Gang, Taylor E. Arnoff, Rebecca C. Larson, John G. Doench, Nathan D. Mathewson, Kai W. Wucherpfennig, Marcela Valderrama Maus, William C. Hahn · 2023
Data from Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment
Tan-Trieu Nguyen, LeeAnn Ramsay, Mozhdeh Ahanfeshar-Adams, Mathieu Lajoie, Dirk Schadendorf, Tommy Alain, Ian R. Watson · 2023
Data from Heterogeneity of IFN-Mediated Responses and Tumor Immunogenicity in Patients with Cervical Cancer Receiving Concurrent Chemoradiotherapy
Jianzhou Chen, Chuangzhen Chen, Yizhou Zhan, Li Zhou, Jie Chen, Qingxin Cai, Yanxuan Wu, Zhihan Sui, Chengbing Zeng, Xiaolong Wei et al. · 2023
Data from Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment
Tan-Trieu Nguyen, LeeAnn Ramsay, Mozhdeh Ahanfeshar-Adams, Mathieu Lajoie, Dirk Schadendorf, Tommy Alain, Ian R. Watson · 2023
Data from Heterogeneity of IFN-Mediated Responses and Tumor Immunogenicity in Patients with Cervical Cancer Receiving Concurrent Chemoradiotherapy
Jianzhou Chen, Chuangzhen Chen, Yizhou Zhan, Li Zhou, Jie Chen, Qingxin Cai, Yanxuan Wu, Zhihan Sui, Chengbing Zeng, Xiaolong Wei et al. · 2023
Data from CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade
Guangchuan Wang, Ryan Dz-Wei Chow, Lvyun Zhu, Zhigang Bai, Lupeng Ye, Feifei Zhang, Paul A. Renauer, Matthew B. Dong, Xiaoyun Dai, Xiaoya Zhang et al. · 2023
Data from A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing
Patrick Hall Lizotte, Ruey‐Long Hong, Troy A. Luster, Megan E. Cavanaugh, Luke J. Taus, Stephen Wang, Abha Dhaneshwar, Naomi A. Mayman, Aaron Yang, Meghana M. Kulkarni et al. · 2023
Figure S15 from Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
Avinash D Sahu, Xiaoman Wang, Phillip B. Munson, Jan P.G. Klomp, Xiaoqing Wang, Shengqing Stan Gu, Ya Han, Gege Qian, Phillip B. Nicol, Zexian Zeng et al. · 2023
Data from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers
Di Wang, Jianchao Wang, Dongmei Zhou, Zhixian Wu, Wei Liu, Yanping Chen, Gang Chen, Jing Zhang · 2023
The Role of Epigenetic Dysregulation in Lymphoma Biology
Qing Deng and, Michael R. Green · 2023
Digging deeper into the early steps of cancer progression
Jonathan H. Sussman, Ben Z. Stanger · 2023 · Trends in cancer
POTENCIAL TERAPÊUTICO CONTRA O CÂNCER UTILIZANDO A TECNOLOGIA DE EDIÇÃO DE GENES CRISPR-CAS9: UMA REVISÃO DA LITERATURA
Winne Cunha Cardoso, Andrei Santos Siqueira · 2023 · Revista CPAQV - Centro de Pesquisas Avançadas em Qualidade de Vida
Homeostatic Dysregulation of Systemic CD8 + T Cell Compartment in Lung Cancer Patients
Sung‐Woo Lee, Ju Sik Yun, Young Ju Kim, Hee-Ok Kim, Hyun-Ju Cho, Cheol‐Kyu Park, In‐Jae Oh, Jae-Ho Cho · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Risk model based on genes regulating the response of tumor cells to T-cell-mediated killing in esophageal squamous cell carcinoma
Xun Zhang, Chuting Yu, Siwei Zhou, Yanhui H. Zhang, Bo Tian, Yan Bian, Wei Wang, Han Lin, Luo‐Wei Wang · 2024 · Aging
Generation and utilization of endostatin‐sensitive cell lines for assessing the biological activity of endostatin
Xi Qin, Yifang An, Xiang Olivia Li, Fang Huang, Yong Feng Zhou, Dening Pei, Hua Bi, Xinchang Shi, Wenhong Fan, Youxue Ding et al. · 2024 · MedComm
Additional file 2 of Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide
Jinghong Chen, Zhixiang Zuo, Gao, Yan, Xiaosai Yao, Peiyong Guan, Yali Wang, Zhimei Li, Zhilong Liu, Jing Han Hong, Peng Deng et al. · 2023 · Figshare
Pooled genetic screens identify breast cancer risk genes involved in evasion from T cell-mediated killing
Wei Shi, Yi Luo, Jacqueline M. Burrows, Debra M. Black, Andrew Civitarese, Laura Perlaza-Jiménez, Ping Zhang, Murray Manning, Natasha Tuano, Miguel E. Rentería et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Mechanisms of resistance to immunotherapy
Bernadette Blauensteiner, Theresa Lentner, Verónica Moreno‐Viedma · 2024 · Elsevier eBooks
Small Intestine Metastasis Leads to the Diagnosis of Thoracic SMARCA4-Deficient Undifferentiated Tumor: A Case Report
Rei Sanai, Toyoshi Yanagihara, Takato Ikeda, Kaori Koga, Yuki Shundo, Naoki Hamada, Noriyuki Ebi, Hiroyuki Inoue, Yoshihiro Hamada, Makoto Hamasaki et al. · 2024 · Cureus
Bridging the Gap in Immunotherapy Prediction: The AGAE Score as a Pan-Cancer Biomarker for Immune Checkpoint Inhibitor Response
Bicheng Ye, Jun Fan, Qingren Meng, Xiaoqing Liang, Aimin Jiang, Pengpeng Zhang · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Immune-oncology potential of KRAS inhibitors
Míriam Molina‐Arcas, Jesse Boumelha, Julian Downward · 2024 · Elsevier eBooks
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
Kavita K. Desai, Patricia D.B. Tiburcio, Austin Warne, Arash Nabbi, Serena Zhou, Sean D. Reiff, Matthew E. Campbell, Kenneth Sung-Man Chen · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Case report: Aggressive NSCLC with partial BRG-1 deficiency and KRAS G12C mutation: a case study and treatment challenges
Chengwei Jin, Hong Ge, Dongsheng Hou, Jing Li, Mingming Tan · 2024 · Frontiers in Oncology
The prognostic impact of PBRM1 immunohistochemical expression and its association with CD3 + and CD8 + immune cells in patients with renal cell carcinoma: A retrospective study
Amira Emad Elwy, Mahmoud Ismail Nassar, Shimaa Hassan Shaban, Tarek Mohamed Elsaba · 2025 · Pathology - Research and Practice
Immunotherapeutic Approaches in Glioblastoma
Mobina Fathi, Mohammad Amin Sadeghi, Amir Mohammad Vahdani, Nima Rezaei · 2025 · Interdisciplinary cancer research
A case of SMARCA4-deficient multifocal cancer of unknown primary site
Yifan Huang, Qianhao Huang, Zhiyong Zhang, Yuedong Chen · 2025 · Asian Journal of Surgery
Cancer-associated Fibroblasts in Pan-Cancer Drive CXCR2+VNN2+ Neutrophils Reprogramming to Mediate Immunosuppression and Immunotherapy Resistance
Zhiyu Guo, Xujia Li, Lingli Huang, Yue Yan, Mengge Gao, Jinsheng Huang · 2025 · Research Square
Identification of metabolism-associated molecular classification for effect and prognosis in lung adenocarcinoma based on multidatabases including the cancer genome atlas and gene expression omnibus
Lilin Que, Zhibing Liu, Yinghui Wu, Lan Luo, Leifeng Liang · 2025 · SAGE Open Medicine
SMARCA4-deficient Undifferentiated Thoracic Tumor That Responded to Pembrolizumab Monotherapy in a Patient with a Poor Performance Status
Daiki Murata, Koichi Azuma, Kenji Tsumura, Tomohiro Tanaka, Yoshihisa Tokunaga, Yoshiaki Zaizen, Tomoaki Hoshino · 2025 · Haigan
Autonomic nervous system development-related signature as a novel predictive biomarker for immunotherapy in pan-cancers
Cunen Wu, Weiwei Xue, Yuwen Zhuang, Dayue Darrel Duan, Zhou Zhou, Xiaoxiao Wang, Zhenfeng Wu, Jin‐Yong Zhou, Xiangkun Huan, Ruiping Wang et al. · 2025 · Frontiers in Immunology