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Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing
Open accessAbstract
Transistor sensing in salt solutions: Molecular binding to receptors on the surface of field-effect transistors (FETs) can be sensed through changes in transconductance. However, the saline solutions typically used with biomolecules create an electrical double layer that masks any events that occur within about 1 nanometer from the surface. Nakatsuka et al. overcame this limitation by using binding to large, negatively charged DNA stem loop structures that, upon ligand binding, cause conformational changes that can be sensed with an FET, even in solutions with high ionic strength. The authors demonstrate the sensing of charged molecules such as dopamine in artificial cerebrospinal fluid as well as neutral molecules such as glucose and zwitterion molecules like sphingosine-1-phosphate. Science , this issue p. 319
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On the origin of enhanced sensitivity in nanoscale FET-based biosensors
Shoorideh, K., & Chui, C. O. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315485111 · Cited by 162
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Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives
Li, L., Xu, S., Yan, H., Li, X., Yazd, H. S., Li, X., Huang, T., Cui, C., Jiang, J., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202003563 · Cited by 432
Employing Conductive Metal–Organic Frameworks for Voltammetric Detection of Neurochemicals
Ko, M., Mendecki, L., Eagleton, A. M., Durbin, C. G., Stolz, R. M., Meng, Z., & Mirica, K. A. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b13402 · Cited by 298
Biomolecular sensors for advanced physiological monitoring
Flynn, C. D., Chang, D., Mahmud, A., Yousefi, H., Das, J., Riordan, K. T., Sargent, E. H., & Kelley, S. O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00067-z · Cited by 226
Recent advances in neurotechnologies with broad potential for neuroscience research
Vázquez-Guardado, A., Yang, Y., Bandodkar, A. J., & Rogers, J. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00739-8 · Cited by 202
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Metadata
- Authors
- Nakatsuka, N., Yang, K.-A., Abendroth, J. M., Cheung, K. M., Xu, X., Yang, H., Zhao, C., Zhu, B., Rim, Y. S., Yang, Y., Weiss, P. S., Stojanović, M. N., & Andrews, A. M.
- Venue
- Science
- Published
- 2018-10-19
- Volume
- 362
- Issue
- 6412
- Pages
- 319-324
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2891599654
- Cited by
- 951
- References
- 1
- FWCI
- 19.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Nakatsuka, N., Yang, K.-A., Abendroth, J. M., Cheung, K. M., Xu, X., Yang, H., Zhao, C., Zhu, B., Rim, Y. S., Yang, Y., Weiss, P. S., Stojanović, M. N., & Andrews, A. M. (2018). Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing. Science. https://doi.org/10.1126/science.aao6750
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