The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Catalytic enantioselective Minisci-type addition to heteroarenes
Open accessAbstract
Light and acid steer a radical addition: So-called Minisci reactions have been used for decades in pharmaceutical and agrochemical synthesis to make carbon-carbon bonds. The reactions link carbon radicals to the carbon centers adjacent to nitrogen in pyridine rings. Proctor et al. devised a method to steer these reactions to just one of two possible mirror-image products. To make the radicals, they prepared derivatives of widely available amino acids and then activated them with an iridium photocatalyst. At the same time, a chiral phosphoric acid catalyst was used to activate the pyridine and bias the reaction geometry. Science , this issue p. 419
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Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
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The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
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Innate C-H trifluoromethylation of heterocycles
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Alcohols as alkylating agents in heteroarene C–H functionalization
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Metadata
- Authors
- Proctor, R. S. J., Davis, H. J., & Phipps, R. J.
- Venue
- Science
- Published
- 2018-04-27
- Volume
- 360
- Issue
- 6387
- Pages
- 419-422
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2795687764
- Cited by
- 527
- References
- 36
- FWCI
- 24.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Proctor, R. S. J., Davis, H. J., & Phipps, R. J. (2018). Catalytic enantioselective Minisci-type addition to heteroarenes. Science. https://doi.org/10.1126/science.aar6376
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
