The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Separating host and microbiome contributions to drug pharmacokinetics and toxicity
Open accessAbstract
Off-target drug metabolism: Anything humans swallow is exposed to the foraging and transforming activities of the gut microbiota. This applies to therapeutic drugs as well as food components and can be a major source of interpersonal variation in drug efficacy and toxicity. Zimmermann et al. found that individual drug responses depend on the genetics of an individual's microbiota. They explored the metabolism of nucleoside drugs (which are used as antivirals and antidepressants) in mice inoculated with a variety of mutant microbiota. They then modeled the pharmacokinetics in different body compartments and identified the host and microbe contributions. In some individuals, up to 70% of drug transformation can be ascribed to microbial metabolism. Science , this issue p. eaat9931
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Cites
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“ovatus possess the highest metabolic activity, consistent with previous reports thatmembers of this genus can metabolize the structurally similar drug sorivudine (7).”
BackgroundFerl, G. Z., Theil, F., & Wong, H. (2016) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.1994 · Cited by 54
Cited by
Gut microbial metabolites as multi-kingdom intermediates
Krautkramer, K. A., Fan, J., & Bäckhed, F. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0438-4 · Cited by 1,398
Mapping human microbiome drug metabolism by gut bacteria and their genes
Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R., & Goodman, A. L. (2019) · Nature · doi:10.1038/s41586-019-1291-3 · Cited by 1,160
Self-citationDiscovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Maini Rekdal, V., Bess, E. N., Bisanz, J. E., Turnbaugh, P. J., & Balskus, E. P. (2019) · Science · doi:10.1126/science.aau6323 · Cited by 753
Bender, A., & Cortés-Ciriano, I. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.009 · Cited by 405
The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic
Tan, A. H., Lim, S. Y., & Lang, A. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00681-2 · Cited by 392
Metadata
- Authors
- Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R., & Goodman, A. L.
- Venue
- Science
- Published
- 2019-02-08
- Volume
- 363
- Issue
- 6427
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2914718086
- Cited by
- 423
- References
- 4
- FWCI
- 49.17
- Type
- journal article
- Language
- en
- Open access
- green
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