The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Characterizing mutagenic effects of recombination through a sequence-level genetic map
Abstract
Human recombination and mutation mapped: Genetic recombination is an essential process in generating genetic diversity. Recombination occurs both through the shuffling of maternal and paternal chromosomes and through mutations generated by resolution of the physical breaks necessary for this process. Halldorsson et al. sequenced the full genomes of parents and offspring to create a map of human recombination and estimate the relationship with de novo mutations. Interestingly, transcribed regions of the genome were less likely to have crossovers, suggesting that there may be selection to reduce changes in genetic sequences via recombination or mutation in these regions. Science , this issue p. eaau1043
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Metadata
- Authors
- Halldorsson, B. V., Palsson, G., Stefansson, O. A., Jonsson, H., Hardarson, M. T., Eggertsson, H. P., Gunnarsson, B., Oddsson, A., Halldorsson, G. H., Zink, F., Gudjonsson, S. A., Frigge, M. L., Thorleifsson, G., Sigurdsson, A., Stacey, S. N., Sulem, P., Masson, G., Helgason, A., Gudbjartsson, D. F., Thorsteinsdottir, U., & Stefansson, K.
- Venue
- Science
- Published
- 2019-01-25
- Volume
- 363
- Issue
- 6425
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2915041973
- Cited by
- 361
- References
- 112
- FWCI
- 19.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Halldorsson, B. V., Palsson, G., Stefansson, O. A., Jonsson, H., Hardarson, M. T., Eggertsson, H. P., Gunnarsson, B., Oddsson, A., Halldorsson, G. H., Zink, F., Gudjonsson, S. A., Frigge, M. L., Thorleifsson, G., Sigurdsson, A., Stacey, S. N., Sulem, P., Masson, G., Helgason, A., Gudbjartsson, D. F., . . . Stefansson, K. (2019). Characterizing mutagenic effects of recombination through a sequence-level genetic map. Science. https://doi.org/10.1126/science.aau1043
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