Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

Maniatis, Silas, Äijö, Tarmo, Vickovic, Sanja, Braine, Catherine, Kang, Kristy, Mollbrink, Annelie, Fagegaltier, Delphine, Andrusivová, Žaneta, Saarenpää, Sami, Saiz-Castro, Gonzalo, Cuevas, Miguel, Watters, Aaron, Lundeberg, Joakim, Bonneau, Richard, Phatnani, Hemali·2019·Science

DOI 10.1126/science.aav9776

Cited by (428)

Items 201–300 of 428

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma
Wajd N. Al‐Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan D. Oneka, Ziad Fehmi, Roel G.W. Verhaak, Hoon Kim, Drew W. Pratt, Sandra Ines Camelo-Piragua et al. · 2023 · Neoplasia
Anti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine
Ilaria Piano, Arianna Votta, Patrizia Colucci, Francesca Corsi, Sara Vitolo, Chiara Cerri, Dario Puppi, Michele Lai, José Fernando Maya‐Vetencourt, Massimiliano Leigheb et al. · 2023 · Scientific Reports
Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS
Cinzia Volonté, Giovanna Morello, Antonio Gianmaria Spampinato, Susanna Amadio, Savina Apolloni, Velia D’Agata, Sebastiano Cavallaro · 2020 · Ageing Research Reviews
Detection of differentially expressed genes in spatial transcriptomics data by spatial analysis of spatial transcriptomics: A novel method based on spatial statistics
Zhihua Julia Qiu, Shaojun Li, Ming Luo, Shuanggen Zhu, Yongjun Jiang, Zhijian Wang · 2022 · Frontiers in Neuroscience
Recent advances in differential expression analysis for single-cell RNA-seq and spatially resolved transcriptomic studies
Xiya Guo, Jin Ning, Yuanze Chen, Guoliang Liu, Liyan Zhao, Yue Fan, Shiquan Sun · 2023 · Briefings in Functional Genomics
Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway
Marjan Talebi, Mohammad Mehdi Sadoughi, Seyed Abdulmajid Ayatollahi, Elaheh Ainy, Roghayeh Kiani, Alireza Zali, Mir Mohammad Miri · 2023 · Biomedicine & Pharmacotherapy
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors
Violena Pietrobon, Alessandra Cesano, Francesco Maria Marincola, Jakob Nikolas Kather · 2021 · Frontiers in Immunology
Single-cell analysis of regions of interest (SCARI) using a photosensitive tag
Anne M. van der Leun, Mirjam E. Hoekstra, Luuk Reinalda, Colinda L. G. J. Scheele, Mireille Toebes, Michel J. van de Graaff, Linda Y. Y. Chen, Hanjie Li, Akhiad Bercovich, Yaniv Lubling et al. · 2021 · Nature Chemical Biology
sTREM2 cerebrospinal fluid levels are a potential biomarker in amyotrophic lateral sclerosis and associate with UMN burden
Lin Jiao, Jing Yang, Wenjing Wang, Xiangyi Liu, Yu Fu, Dongsheng Fan · 2024 · Frontiers in Neurology
Advances in Spatial Omics Technologies
Tianxiao Hui, Jian Zhou, Muchen Yao, Ying Xie, Hu Zeng · 2025 · Small Methods
Spatial profiling technologies and applications for brain cancers
Priyakshi Kalita‐de Croft, Habib Sadeghirad, Harry Michael Gasper, Kenneth John O'Byrne, Sunil R. Lakhani, Arutha Kulasinghe · 2021 · Expert Review of Molecular Diagnostics
A convolutional neural network for common coordinate registration of high-resolution histology images
Aidan C. Daly, Krzysztof J. Geras, Richard Bonneau · 2021 · Bioinformatics
Retromer dysfunction in amyotrophic lateral sclerosis
Eduardo J. Pérez-Torres, Irina V. Utkina-Sosunova, Vartika R. Mishra, Peter A. Barbuti, Mariangels De Planell-Saguer, Georgia Dermentzaki, Heather M. Geiger, Anna Okula Basile, Nicolas Robine, Delphine Fagegaltier et al. · 2022 · Proceedings of the National Academy of Sciences
Single-Cell RNA-Sequencing in Astrocyte Development, Heterogeneity, and Disease
Meng-Yuan Gao, Jiaqi Wang, Jin Mei He, Rui Gao, Yuan Zhang, Xing Li · 2023 · Cellular and Molecular Neurobiology
Montelukast improves disease outcome in SOD1G93A female mice by counteracting oligodendrocyte dysfunction and aberrant glial reactivity
Stefano Raffaele, Nhung Nguyen, Marco Milanese, Francesca Carolina Mannella, Marta Boccazzi, Giulia Frumento, Giambattista Bonanno, Maria P. Abbracchio, Tiziana Bonifacino, Marta Fumagalli · 2024 · British Journal of Pharmacology
Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation
Ana M. Mesa, Jiude Mao, Manjunatha K. Nanjappa, Theresa I. Medrano, Sergei G. Tevosian, Fahong Yu, Jessica A. Kinkade, Zhen Lyu, Yang Liu, Trupti Joshi et al. · 2019 · Physiological Genomics
Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration
Manling Xie, Yue Liang, Alessandra S. Miller, Praveen N. Pallegar, Anthony D. Umpierre, Na Wang, Shuwen Zhang, Nagaswaroop Kengunte Nagaraj, Zachary C. Fogarty, Nikhil B Ghayal et al. · 2025 · Immunity
Bridging scales: From cell biology to physiology using in situ single-cell technologies
Maeve Patricia Nagle, Gabriela S. Tam, Evan Maltz, Zachary Hemminger, Roy Wollman · 2021 · Cell Systems
Bone Marrow Stromal Cell Antigen 2: Is a Potential Neuroinflammation Biomarker of SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis in Pre-symptomatic Stage
Xiaojiao Xu, Jingjing Zhang, Song Li, Murad Al‐Nusaif, Qinming Zhou, Sheng Chen, Weidong Le · 2022 · Frontiers in Neuroscience
Spatial–temporal pattern of propagation in amyotrophic lateral sclerosis and effect on survival: A cohort study
Tianmi Yang, Qianqian Wei, Chunyu Li, Bei Cao, Ruwei Ou, Yanbing Hou, Lingyu Zhang, Xiaojing Gu, Kuncheng Liu, Junyu Lin et al. · 2022 · European Journal of Neurology
Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS
Marie‐Laure Clénet, James Keaney, Gaëlle Gillet, Jorge S. Valadas, Julie Langlois, Alvaro Cardenas, Julien Gasser, Irena Kadiu · 2023 · Frontiers in Immunology
Navigating the landscapes of spatial transcriptomics: How computational methods guide the way
Runze Li, Xu Chen, Xuerui Yang · 2024 · Wiley Interdisciplinary Reviews - RNA
Assessment of diagnostic potential of some circulating microRNAs in Amyotrophic Lateral Sclerosis Patients, an Egyptian study
Radwa Soliman, Nahla O. Mousa, Hebatallah Reda Rashed, Ramez Reda Moustafa, Nabila Hamdi, Ahmad Osman, Nagia Aly Fahmy · 2021 · Clinical Neurology and Neurosurgery
Mapping Gene Expression in the Spatial Dimension
Yingwen Chen, Weizhou Qian, Li Lin, Linfeng Cai, Kun Yin, Shaowei Jiang, Jia Tao Song, Ray P. S. Han, Chaoyong James Yang · 2021 · Small Methods
SOAR elucidates disease mechanisms and empowers drug discovery through spatial transcriptomics
Yiming Li, Saya Dennis, Meghan R. Hutch, Yanyi Ding, Yadi Zhou, Yawei Li, Maalavika Pillai, Sanaz Ghotbaldini, Mario Garcia, Mia S. Broad et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Spatial transcriptomics in focal cortical dysplasia type IIb
Yujiao Wang, Yihe Wang, Linai Guo, Chunhao Shen, Yongjuan Fu, Penghu Wei, Yongzhi Shan, Qian Wu, Yue-Shan Piao, Guoguang Zhao · 2024 · Acta Neuropathologica Communications
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Melissa Erin Murray, Colin Smith, Vilas Menon, Christopher Dirk Keene, Ed S. Lein, Michael Hawrylycz, Adriano Aguzzi, Brett L. Benedetti, Katja Brose, Kelsey Caetano-Anollés et al. · 2025 · Neuron
Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models
Jingshu Tang, Yuying Kang, Yujun Zhou, Qiuyu Chen, Jiaqi Lan, Xuebin Liu, Ying Peng · 2023 · Brain Research Bulletin
Single‐cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases
Ziping He, Qianqian Chen, Kaiyue Wang, Jiang Lin, Yilin Peng, Jinlong Zhang, Xisheng Yan, Jie Yan · 2024 · European Journal of Neuroscience
Cell Heterogeneity and Variability in Peripheral Nerve after Injury
Zhixian Ren, Ya Tan, Lili Zhao · 2024 · International Journal of Molecular Sciences
Little Helpers or Mean Rogue—Role of Microglia in Animal Models of Amyotrophic Lateral Sclerosis
Hilal Cihankaya, Carsten Theiß, Veronika Matschke · 2021 · International Journal of Molecular Sciences
Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin
Lucile Mégret, Barbara Gris, Satish Sasidharan Nair, Jasmin Cevost, Mary H. Wertz, Jeff Aaronson, Jim Rosinski, Thomas Vogt, Hilary A. Wilkinson, Myriam Heiman et al. · 2021 · eLife
Spatial transcriptomics analysis of uterine gene expression in enhancer of zeste homolog 2 conditional knockout mice†
Ana M. Mesa, Jiude Mao, Theresa I. Medrano, Nathan J. Bivens, Alexander Jurkevich, Geetu Tuteja, Paul S. Cooke, Cheryl Susan Rosenfeld · 2021 · Biology of Reproduction
Integrated transcriptomic profiling reveals a STING-mediated Type II Interferon signature in SOD1-mutant amyotrophic lateral sclerosis models
Jen Young Hiew, Young-Bock Lim, Huitao Liu, Chen Seng Ng · 2025 · Communications Biology
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord
John F. Tuddenham, Masashi Fujita, Emily Lee, Nivedita Nimmagadda, Anthony Khairallah, Claire Harbison, Xena E. Flowers, Guillermo Coronas‐Samano, Silas Maniatis, Aidan C. Daly et al. · 2025 · Acta Neuropathologica
Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies
Eleanor C Williams, Lovisa Franzén, Martina Olsson Lindvall, Gregory R. Hamm, Steven Oag, Muntasir Mamun Majumder, James Denholm, Azam Hamidinekoo, Javier Escudero Morlanes, Marco Vicari et al. · 2026 · Nature Communications
Systems Biology to Address Unmet Medical Needs in Neurological Disorders
Masha G. Savelieff, Mohamed H. Noureldein, Eva L. Feldman · 2022 · Methods in molecular biology
Cumulative Genetic Score and C9orf72 Repeat Status Independently Contribute to Amyotrophic Lateral Sclerosis Risk in 2 Case-Control Studies
John Dou, Kelly M. Bakulski, Kai Guo, Junguk Hur, Lili Zhao, Sara Sáez-Atiénzar, Ali R. Stark, Ruth Chia, Alberto García‐Redondo, Ricard Rojas‐García et al. · 2023 · Neurology Genetics
The role of Matrin-3 in physiology and its dysregulation in disease
Macy L. Sprunger, Meredith E. Jackrel · 2024 · Biochemical Society Transactions
Promising animal models for amyotrophic lateral sclerosis drug discovery: a comprehensive update
Léa Lescouzères, Shunmoogum A. Patten · 2024 · Expert Opinion on Drug Discovery
CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS
Mariángeles Kovacs, Emiliano Trías, Valentina Varela, Sofía Ibarburu, Joseph S. Beckman, Ivan Cruz Moura, Olivier Hermine, Peter H. King, Ying Si, Yuri Kwon et al. · 2019 · International Journal of Molecular Sciences
Synaptic Cell Adhesion Molecule 3 (SynCAM3) Deletion Promotes Recovery from Spinal Cord Injury by Limiting Glial Scar Formation
Byeong Gwan Song, Su Yeon Kwon, Jae Won Kyung, Eun Ji Roh, Hyemin Choi, Chang Su Lim, Seong Bae An, Seil Sohn, Inbo Han · 2022 · International Journal of Molecular Sciences
Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response
Christine Germeys, Tijs Vandoorne, Kristofer Davie, Suresh Kumar Poovathingal, Kara Heeren, Wendy Vermeire, Fatemeharefeh Nami, Matthieu Moisse, Annelies Quaegebeur, Annerieke S. R. Sierksma et al. · 2024 · Cell Reports
An open source toolkit for repurposing Illumina sequencing systems as versatile fluidics and imaging platforms
Kunal Pandit, Joana Petrescu, Miguel Cuevas, William Stephenson, Peter Smibert, Hemali P. Phatnani, Silas Maniatis · 2022 · Scientific Reports
Harnessing computational spatial omics to explore the spatial biology intricacies
Zhiyuan Yuan, Jianhua Yao · 2023 · Seminars in Cancer Biology
Unleashing Axonal Regeneration Capacities: Neuronal and Non-neuronal Changes After Injuries to Dorsal Root Ganglion Neuron Central and Peripheral Axonal Branches
Qian Zhao, Chun‐Yi Jiang, Li Zhao, XIU HONG DAI, Sheng Yi · 2023 · Molecular Neurobiology
Lessons from single cell sequencing in CNS cell specification and function
Zhen Li, William A. Tyler, Tarik F. Haydar · 2020 · Current Opinion in Genetics & Development
Single nucleus sequencing fails to detect microglial activation in human tissue
N. Thrupp, Carlo Sala Frigerio, L. Wolfs, Nathan Skene, S. Poovathingal, Y. Fourne, Paul McMahan Matthews, Tom Theys, Renzo Mancuso, Bart De Strooper et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Dynamic Intercellular Networks in the CNS: Mechanisms of Crosstalk from Homeostasis to Neurodegeneration
Yutian Zheng, Rui Huang, Jie Pan · 2025 · International Journal of Molecular Sciences
Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis
Molly E. V. Swanson, Miran Mrkela, Clinton P. Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter · 2025 · Acta Neuropathologica Communications
Single-cell transcriptomic analyses reveal cellular and molecular patterns of rose petal responses to gray mold infection
Xuejiao Li, Yinqi Siman, Yan Zhao, Lvchun Peng, Hongzhi Wu, Wenling Guan, Jingli Zhang, Yanfei Cai, Zhengan Yang, Gengyun Li et al. · 2025 · Horticulture Research
SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics
Yiming Li, Yanyi Ding, Saya Dennis, Meghan R. Hutch, Jiaqi Zhou, Yadi Zhou, Yawei Li, Maalavika Pillai, Sanaz Ghotbaldini, Mario Garcia et al. · 2025 · Science Advances
Toward a Liver Cell Atlas: Understanding Liver Biology in Health and Disease at Single-Cell Resolution
Lichun Ma, Subreen A. Khatib, Amanda J. Craig, Xin Wei Wang · 2021 · Seminars in Liver Disease
The aOECs Facilitate the Neuronal Differentiation of Neural Stem Cells in the Inflammatory Microenvironment Through Up-Regulation of Bioactive Factors and Activation of Wnt3/β-Catenin Pathway
Yuqing He, Yizhen Jiang, Lianwei Dong, Chao Qiang Jiang, Lingling Zhang, Gaorong Zhang, Hao Yang, Juan Liu · 2022 · Molecular Neurobiology
Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases
Ye Man Tang, Nisha S. Pulimood, Stefano Stifani · 2022 · ASN NEURO
Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology
Tereza Filipi, Zuzana Matusova, Pavel Abaffy, Ondřej Vaňátko, Jana Turečková, Sarka Benesova, Monika Kubiskova, Denisa Kirdajová, Jakub Zahumenský, Lukáš Valihrach et al. · 2023 · Scientific Reports
Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis
Sai Zhang, Johnathan Cooper‐Knock, Annika K K Weimer, Minyi Shi, Tobias Moll, Calum Harvey, Helia Ghahremani Nezhad, John Franklin, Cleide Dos Santos Souza, Cheng Wang et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Deciphering Spatial Domains by Integrating Histopathological Image and Transcriptomics via Contrastive Learning
Yuansong Zeng, Rui Yin, Mai Luo, Jianing Chen, Zixiang Pan, Yutong Lu, Weijiang Yu, Yuedong Yang · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications
Qianwen Wang, Hongyuan Zhu, Linhong Deng, Shuangbin Xu, Wenqin Xie, Ming Li, Rui Wang, Liang Tie, Li Zhan, Guangchuang Yu · 2025 · Small Methods
Exploring and mitigating shortcomings in single-cell differential expression analysis with a new statistical paradigm
Chih-Hsuan Wu, Xiang Zhou, Mengjie Chen · 2025 · Genome biology
Tissue and cellular spatiotemporal dynamics in colon aging
Aidan C. Daly, Francesco Cambuli, Tarmo Äijö, Britta Lötstedt, Nemanja Despot Marjanovic, Sara Fernandez, Olena Kuksenko, Matthew Smith-Erb, Daniel Domovic, Nicholas Van Wittenberghe et al. · 2025 · Nature Biotechnology
A pilot study on searching for peri-nuclear NeuN-positive cells
Yun Yu, Maohua Wu, Nan Zhang, Hua Yin, Bin Shu, Weigang Duan · 2020 · PeerJ
Spatial transcriptome sequencing revealed spatial trajectory in the Non-Small Cell Lung Carcinoma
Li Zhang, Shengqiang Mao, Menglin Yao, Ningning Chao, Ying Yang, Yinyun Ni, Tingting Song, Zhiqiang Liu, Yongfeng Yang, Weimin Li · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Multiplexed spatial transcriptomics methods and the application of expansion microscopy
Fortner, Andra, Bucur, Octavian · 2024 · Frontiers in Cell and Developmental Biology
Towards an integrated approach for understanding glia in Amyotrophic Lateral Sclerosis
Stanisław Majewski, Pierre Klein, Séverine Boillée, Benjamin E. Clarke, Rickie Patani · 2024 · Glia
Causal ALS genes impact the MHC class II antigen presentation pathway
Binkai Chi, Muhammet M. Öztürk, Christina L. Paraggio, Claudia E. Leonard, Maria E. Sanita, Mahtab Dastpak, Jeremy D. O’Connell, Jordan A. Coady, Jiuchun Zhang, Steven P. Gygi et al. · 2023 · Proceedings of the National Academy of Sciences
Emerging Roles of Spatial Transcriptomics in Liver Research
Naoto Fujiwara, Genki Kimura, Hayato Nakagawa · 2024 · Seminars in Liver Disease
The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging
M. Brandon Titus, Ethan G. Wright, Jeremy M. Bono, Andrea K. Poliakon, Brandon R. Goldstein, Meg K. Super, Lauren A. Young, Melpomeni Manaj, Morgan L. Litchford, Noreen E. Reist et al. · 2021 · Developmental Biology
Systems Biology Approaches as a Tool in Understanding Neurodevelopmental Disorders: Some Case Studies
Anuvab Dey, Subhrojyoti Ghosh, Sourav Majhi, Aishee Nishat Hoque, Aneshwa Chakrabarti · 2024 · Springer eBooks
The application and prospects of spatial omics technologies in clinical medical research and molecular diagnostics
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Lit‐Hsin Loo, Jinxia Dai, Gang Cao · 2025 · Journal of genetics and genomics/Journal of Genetics and Genomics
In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment
Anna Lyubetskaya, Brian A. Rabe, Andrew J. Kavran, Yulong Bai, Andrew Fisher, Alba Font‐Tello, Anne C. Lewin, Hannah A. Pliner, Yunfan Fan, Lauren Giampapa et al. · 2026 · Cell Reports
Spatially Resolved Expression of Transposable Elements in Disease and Somatic Tissue with SpatialTE
Braulio Valdebenito‐Maturana, Cristina Guatimosim, Mónica A. Carrasco, Juan Carlos Tapia · 2021 · International Journal of Molecular Sciences
The industrial genomic revolution: A new era in neuroimmunology
Rotem Shalita, Ido Amit · 2022 · Neuron
Spatial resolved transcriptomics: Computational insights into gene transcription across tissue and organ architecture in diverse applications
Zhen Miao, Tian Tian, Wei Chen, Qianwen Wang, Liang Ma, Dan Zhang, Min Xie, Zijin Yu, Xiya Guo, Genxiang Bai et al. · 2024 · The Innovation Life
Novel integrated multiomics analysis reveals a key role for integrin beta-like 1 in wound scarring
Sang Eun Kim, Ryota Noda, Yu‐Chen Liu, Yukari Nakajima, Shoichiro Kameoka, Daisuke Motooka, Seiya Mizuno, Satoru Takahashi, Kento Takaya, Takehiko Murase et al. · 2024 · EMBO Reports
Spatial Reconstruction of Oligo and Single Cells by De Novo Coalescent Embedding of Transcriptomic Networks
Yuxuan Zhao, Shiqiang Zhang, Jian Xu, Yangyang Yu, Guangdun Peng, Carlo Vittorio Cannistraci, Jing‐Dong J. Han · 2023 · Advanced Science
Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities
Yuliang Wang, Shuyi Ma, Walter L. Ruzzo · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Single-cell transcriptomic analysis of the adult mouse spinal cord
Jacob A. Blum, Sandy L. Klemm, Lisa Nakayama, Arwa S. Kathiria, Kevin A. Guttenplan, Phuong T. Hoang, Jennifer L. Shadrach, Julia A. Kaltschmidt, William James Greenleaf, Aaron D. Gitler · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Rod-shaped microglia interact with neuronal dendrites to regulate cortical excitability in TDP-43 related neurodegeneration
Manling Xie, Alessandra S. Miller, Praveen N. Pallegar, Anthony D. Umpierre, Yue Liang, Na Wang, Shuwen Zhang, Nagaswaroop Kengunte Nagaraj, Zachary C. Fogarty, Nikhil B Ghayal et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
TriDeNT : Triple deep network training for privileged knowledge distillation in histopathology
Lucas Farndale, Robert H. Insall, Ke Yuan · 2025 · Medical Image Analysis
SCAN: Spatiotemporal Cloud Atlas for Neural cells
Yushan Deng, Yubao Lu, Mengrou Li, Jiayi Shen, Siying Qin, Wei Zhang, Qiang Zhang, Zhaoyang Shen, Changxiao Li, Tengfei Jia et al. · 2023 · Nucleic Acids Research
A reproducible signature of cytoskeletal and ALS-related genes in human motoneurons
Archana Yadav, Kaya J.E. Matson, Dylan I. Lee, Mor R. Alkaslasi, Robert Brian Roome, Michael Emmerson Ward, Hemali P. Phatnani, Claire E. Le Pichon, Vilas Menon, Ariel J. Levine · 2023 · Neuron
Image guided construction of a common coordinate framework for spatial transcriptome data
Peter F. Lais, Shawn Mishra, Kun Xiong, Huanan Shi, Gurinder S. Atwal, Yu Bai · 2025 · Scientific Reports
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic
Vivek P. Chavda, Chirag Amrutlal Patel, Dharti H. Modh, Yavuz Nuri Ertaş, Shreya S. Sonak, Nafesa K. Munshi, Krishnan Anand, Arun Soni, Sonal Vijay Pande · 2022 · Current Drug Metabolism
Redox profiles of amyotrophic lateral sclerosis lymphoblasts with or without known SOD1 mutations
Teresa Cunha‐Oliveira, Daniela Franco da Silva, Luis Segura, Inês Baldeiras, Ricardo Marques, Tatiana Rosado Rosenstock, Paulo Jorge Oliveira, Filomena S. G. Silva · 2022 · European Journal of Clinical Investigation
Clinical gene therapy development for the central nervous system: Candidates and challenges for AAVs
Tiffany W. Leong, Arindam Pal, Qi Cai, Zhenghong Gao, Xiaoqing Li, Leonidas G. Bleris, Heather N. Hayenga, Zhenpeng Qin · 2023 · Journal of Controlled Release
RNAscope Multiplex FISH Signal Assessment in FFPE and Fresh Frozen Tissues: The Effect of Archival Duration on RNA Expression
Ariestya Indah Permata Sari, Katherine Kradangna Copeland, Pattarin Nuwongsri, Wiriya Pipatsakulroj, Artit Jinawath, Nipan Israsena, Panuwat Lertsithichai, Prakasit Chirappapha, Meng‐Shin Shiao, Natini Jinawath · 2025 · Journal of Histochemistry & Cytochemistry
Dissecting the tumor ecosystem of liver cancers in the single-cell era
Yue Wang, Pengxiang Wang, Zefan Zhang, Jian Zhou, Jia Fan, Yun‐Fan Sun · 2023 · Hepatology Communications
Spatial transcriptomic profiling of isolated microregions in tissue sections utilizing laser-induced forward transfer
Kaiqiang Ye, Weijie Chang, Jitao Xu, Yunxia Guo, Qingyang Qin, Kaitong Dang, Xiaofeng Han, Xiaolei Zhu, Qinyu Ge, Qiannan Cui et al. · 2024 · PLoS ONE
Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model
Luis Labrador, Leonardo Rodriguez, Sebastián Beltrán, Fernanda Hernandez, Laura Gómez, Patricia Ojeda, Cristian A Bergmann, Melissa Nassif, Bredford Kerr, Danilo B. Medinas et al. · 2024 · Biological Research
Spatial Omics: Navigating Neuroscience Research into the New Era
Pengfei Guo, Yanxiang Deng · 2024 · Advances in neurobiology
An Efficient Method to Detect Messenger RNA (mRNA) in the Inner Ear by RNAscope In Situ Hybridization
Sumana Ghosh, Graham Casey, Kendra L. Stansak, Punam Thapa, Bradley J. Walters · 2022 · Neuromethods
Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints
Teresa Cunha‐Oliveira, Marcelo Carvalho, Vilma A. Sardão, Elisabete B. Ferreiro, Débora Mena, Francisco Baptista Pereira, Fernanda Borges, Paulo Jorge Oliveira, Filomena S. G. Silva · 2022 · Molecular Neurobiology
Spatial domain detection using contrastive self-supervised learning for spatial multi-omics technologies
Jianing Yao, Jinglun Yu, Brian S. Caffo, Stephanie C. Page, Keri Martinowich, Stephanie C. Hicks · 2025 · Genome Research
MEA‐seqX: High‐Resolution Profiling of Large‐Scale Electrophysiological and Transcriptional Network Dynamics
Brett Addison Emery, Xin Hu, Diana Klütsch, Shahrukh Khanzada, Ludvig Larsson, Ionut Dumitru, Jonas Frisén, Joakim Lundeberg, Gerd Kempermann, Hayder Amin · 2025 · Advanced Science
Genotype-specific interferon signatures in amyotrophic lateral sclerosis relate to disease severity
Olga Carletta, Camilla Perfetto, Olivia M. Rifai, Francesca Manganelli, Fergal M. Waldron, Tom Maniatis, Jenna M. Gregory, Valeria Gerbino · 2025 · Brain
Advancements in Genomic and Behavioral Neuroscience Analysis for the Study of Normal and Pathological Brain Function
Annalisa M. Baratta, Adam J. Brandner, Sonja L. Plasil, Rachel C. Rice, Sean P. Farris · 2022 · Frontiers in Molecular Neuroscience
Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice
Ana Laura Midori Rossi Tomiyama, Luciana Politti Cartarozzi, Lilian de Oliveira Coser, Gabriela Bortolança Chiarotto, Alexandre Leite Rodrigues de Oliveira · 2023 · Frontiers in Cellular Neuroscience
Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis
Yingzhen N. Zhang, Lin Chen, Zhongzhong Li, Dongxiao Li, Yue Wu, Yansu Guo · 2022 · Frontiers in Cellular Neuroscience
Spatially resolved transcriptome profiles of mammalian kidneys illustrate the molecular complexity of functional nephron segments, cell-to-cell interactions and genetic variants
Arti M. Raghubar, Duy T. Pham, Xiao Tan, Laura F. Grice, Joanna Crawford, Pui Yeng Lam, Stacey B. Andersen, Sohye Yoon, Monica Suet Ying Ng, Siok Min Teoh et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)