The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
Open accessAbstract
Light teaches (co)enzymes new tricks: Light is widely used in organic synthesis to excite electrons in a substrate or catalyst, opening up reactive pathways to a desired product. Biology uses light sparingly in this way, but coenzymes such as flavin can be driven to excited states by light. Biegasiewicz et al. investigated this reactivity and found a suite of flavoenzymes that catalyze asymmetric radical cyclization when exposed to light. “Ene”-reductases, when reduced and illuminated, converted starting materials containing an α-chloroamide and an alkene into five-, six-, seven-, or eight-membered lactams. Different enzymes furnished different stereochemistry in the products, likely because of changes in active-site pocket geometry. Science , this issue p. 1166
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Becke, A. D. (1993) · The Journal of Chemical Physics · doi:10.1063/1.464913 · Cited by 103,767
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Cheng, L., Li, D., Mai, B. K., Bo, Z., Cheng, L., Liu, P., & Yang, Y. (2023) · Science · doi:10.1126/science.adg2420 · Cited by 253
A De Novo Metalloenzyme for Cerium Photoredox Catalysis
(2024) · doi:10.1021/jacs.4c04618 · Cited by 76
Versatile Applications of Cyanobacteria in Biotechnology
Żymańczyk-Duda, E., Samson, S. O., Brzezińska-Rodak, M., & Klimek-Ochab, M. (2022) · Microorganisms · doi:10.3390/microorganisms10122318 · Cited by 64
Metadata
- Authors
- Biegasiewicz, K. F., Cooper, S. J., Gao, X., Oblinsky, D. G., Kim, J. H., Garfinkle, S. E., Joyce, L. A., Sandoval, B. A., Scholes, G. D., & Hyster, T. K.
- Venue
- Science
- Published
- 2019-06-21
- Volume
- 364
- Issue
- 6446
- Pages
- 1166-1169
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2951766191
- Cited by
- 445
- References
- 4
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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