Sequential replay of nonspatial task states in the human hippocampus
Open accessPublished version of a preprint
Abstract
Replay of activity in the human brain: Electrophysiological recordings in rats and mice have shown that specific hippocampal neuronal activity patterns are sequentially reactivated during rest periods or sleep. Does the human hippocampus also replay activity sequences, even in a nonspatial task, such as, for example, decision-making? Schuck and Niv studied functional magnetic resonance imaging signals in subjects after they had learned a decision-making task. While people rested, the replay of activity patterns in the hippocampus reflected the order of previous task-state sequences. Thus, sequential hippocampal reactivation might participate in decision-making in humans. Science , this issue p. eaaw5181
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References 55 · Cited by 304
Research works printed but not linked: 8
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- Authors
- Schuck, N. W., & Niv, Y.
- Affiliations
- Princeton University (US)
- Corresponding author
- Schuck, Nicolas W.
- Venue
- Science
- Published
- 2019-06-28
- Volume
- 364
- Issue
- 6447
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7241311
- OpenAlex
- W2954020015
- Semantic Scholar
- 5d0263f66e59bda9dddcb319fa78382219b9782f
- Cited by
- 304
- References
- 55
- Citations by year
- 2026: 29 · 2025: 40 · 2024: 53 · 2023: 41 · 2022: 38 · 2021: 49 · 2020: 42 · 2019: 11 · 2018: 1
- FWCI
- 20.33
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R01DA042065)
- John Templeton Foundation
- Max Planck Society (M.TN.BILD0004)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- hippocampal replay, decision-making tasks, orbitofrontal cortex, human hippocampus
- MeSH terms
- Decision Making, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Rest, Young Adult, Neuroimaging
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