Determinants of telomere length across human tissues
Open accessPublished version of a preprint
Abstract
Telomere length within an individual varies in a correlated manner across most tissues.
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A study of telomere length in tissues from 952 individuals concluded that 21 of 24 tissues show age-dependent telomere shortening.
“Although most human data on telomeres are based on studies of leukocytes, a recent study of telomere length in tissues from 952 individuals concluded that 21 out of the 24 tissues studied show age-dependent telomere shortening40.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [40]
Nucleated blood cells show the shortest telomeres among human tissues.
“Nucleated blood cells show the shortest telomeres among human tissues40.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [40]
Estimated telomere length in bulk human tissues does not suggest that average telomeres become critically short in normal ageing, even at old age.
“The estimated telomere length in bulk human tissues does not suggest that on average telomeres become critically short in normal ageing, even at old age17.”
From The central role of DNA damage in the ageing process (2021) · cites this paper as [17]
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References 76 · Cited by 515
- Authors
- Demanelis, K., Jasmine, F., Chen, L. S., Chernoff, M., Tong, L., Delgado, D., Zhang, C., Shinkle, J., Sabarinathan, M., Lin, H., Ramirez, E., Oliva, M., Kim-Hellmuth, S., Stranger, B. E., Lai, T.-P., Aviv, A., Ardlie, K. G., Aguet, F., Ahsan, H., GTEx Consortium, Doherty, J. A., Kibriya, M. G., Pierce, B. L., Aguet, F., Anand, S., Ardlie, K. G., Gabriel, S., Getz, G. A., Graubert, A., Hadley, K., Handsaker, R. E., Huang, K. H., Kashin, S., Li, X., MacArthur, D. G., Meier, S. R., Nedzel, J. L., Nguyen, D. T., Segrè, A. V., Todres, E., Balliu, B., Barbeira, A. N., Battle, A., Bonazzola, R., Brown, A., Brown, C. D., Castel, S. E., Conrad, D. F., Cotter, D. J., Cox, N., Das, S., de Goede, O. M., Dermitzakis, E. T., Einson, J., Engelhardt, B. E., Eskin, E., Eulalio, T. Y., Ferraro, N. M., Flynn, E. D., Fresard, L., Gamazon, E. R., Garrido-Martín, D., Gay, N. R., Gloudemans, M. J., Guigó, R., Hame, A. R., He, Y., Hoffman, P. J., Hormozdiari, F., Hou, L., Im, H. K., Jo, B., Kasela, S., Kellis, M., Kim-Hellmuth, S., Kwong, A., Lappalainen, T., Li, X., Liang, Y., Mangul, S., Mohammadi, P., Montgomery, S. B., Muñoz-Aguirre, M., Nachun, D. C., Nobel, A. B., Oliva, M., Park, Y., Park, Y., Parsana, P., Rao, A. S., Reverter, F., Rouhana, J. M., Sabatti, C., Saha, A., Stephens, M., Stranger, B. E., Strober, B. J., Teran, N. A., Viñuela, A., Wang, G., Wen, X., Wright, F., Wucher, V., Zou, Y., Ferreira, P. G., Li, G., Melé, M., Yeger-Lotem, E., Barcus, M. E., Bradbury, D., Krubit, T., McLean, J. A., Qi, L., Robinson, K., Roche, N. V., Smith, A. M., Sobin, L., Tabor, D. E., Undale, A., Bridge, J., Brigham, L. E., Foster, B. A., Gillard, B. M., Hasz, R., Hunter, M., Johns, C., Johnson, M., Karasik, E., Kopen, G., Leinweber, W. F., McDonald, A., Moser, M. T., Myer, K., Ramsey, K. D., Roe, B., Shad, S., Thomas, J. A., Walters, G., Washington, M., Wheeler, J., Jewell, S. D., Rohrer, D. C., Valley, D. R., Davis, D. A., Mash, D. C., Branton, P. A., Barker, L. K., Gardiner, H. M., Mosavel, M., Siminoff, L. A., Flicek, P., Haeussler, M., Juettemann, T., Kent, W. J., Lee, C. M., Powell, C. C., Rosenbloom, K. R., Ruffier, M., Sheppard, D., Taylor, K., Trevanion, S. J., Zerbino, D. R., Abell, N. S., Akey, J., Chen, L., Demanelis, K., Doherty, J. A., Feinberg, A. P., Hansen, K. D., Hickey, P. F., Jasmine, F., Jiang, L., Kaul, R., Kibriya, M. G., Li, J. B., Li, Q., Lin, S., Linder, S. E., Pierce, B. L., Rizzardi, L. F., Skol, A. D., Smith, K. S., Snyder, M., Stamatoyannopoulos, J., Tang, H., Wang, M., Carithers, L. J., Guan, P., Koester, S. E., Little, A. R., Moore, H. M., Nierras, C. R., Rao, A. K., Vaught, J. B., & Volpi, S.
- Affiliations
- Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.
- University of Chicago (US)
- Rutgers New Jersey Medical School (US)
- ORCID
- Chernoff, Meytal
- Tong, Lin
- Delgado, Dayana
- Zhang, Chenan
- Sabarinathan, Mekala
- Lin, Hannah
- Ramirez, Eduardo
- Lai, Tsung-Po
- Aviv, Abraham
- Ahsan, Habibul
- Anand, Shankara
- Gabriel, Stacey
- Getz, Gad A.
- Graubert, Aaron
- Hadley, Kane
- Handsaker, Robert E.
- Huang, Katherine H.
- Kashin, Seva
- Li, Xiao
- MacArthur, Daniel G.
- Meier, Samuel R.
- Nedzel, Jared L.
- Nguyen, Duyen T.
- Segrè, Ayellet V.
- Todres, Ellen
- Balliu, Brunilda
- Barbeira, Alvaro N.
- Battle, Alexis
- Bonazzola, Rodrigo
- Brown, Christopher D.
- Castel, Stephane E.
- Conrad, Donald F.
- Cotter, Daniel J.
- Cox, Nancy
- Das, Sayantan
- Dermitzakis, Emmanouil T.
- Einson, Jonah
- Engelhardt, Barbara E.
- Eskin, Eleazar
- Eulalio, Tiffany Y.
- Ferraro, Nicole M.
- Flynn, Elise D.
- Gamazon, Eric R.
- Garrido-Martín, Diego
- Gay, Nicole R.
- Gloudemans, Michael J.
- Guigó, Roderic
- He, Yuan
- Hormozdiari, Farhad
- Hou, Lei
- Im, Hae Kyung
- Jo, Brian
- Kasela, Silva
- Kellis, Manolis
- Kwong, Alan
- Lappalainen, Tuuli
- Li, Xin
- Liang, Yanyu
- Mangul, Serghei
- Mohammadi, Pejman
- Montgomery, Stephen B.
- Muñoz-Aguirre, Manuel
- Nachun, Daniel C.
- Nobel, Andrew B.
- Park, YoSon
- Park, Yongjin
- Parsana, Princy
- Rouhana, John M.
- Sabatti, Chiara
- Saha, Ashis
- Stephens, Matthew
- Strober, Benjamin J.
- Teran, Nicole A.
- Viñuela, Ana
- Wang, Gao
- Wen, Xiaoquan
- Wright, Fred
- Wucher, Valentin
- Zou, Yuxin
- Ferreira, Pedro G.
- Li, Gen
- Melé, Marta
- Smith, Anna M.
- Tabor, David E.
- Foster, Barbara A.
- Gillard, Bryan M.
- Hasz, Richard
- Johns, Christopher
- Johnson, Mark
- Moser, Michael T.
- Myer, Kevin
- Jewell, Scott D.
- Rohrer, Daniel C.
- Davis, David A.
- Mash, Deborah C.
- Branton, Philip A.
- Gardiner, Heather M.
- Mosavel, Maghboeba
- Siminoff, Laura A.
- Flicek, Paul
- Haeussler, Maximilian
- Juettemann, Thomas
- Lee, Christopher M.
- Rosenbloom, Kate R.
- Ruffier, Magali
- Sheppard, Dan
- Taylor, Kieron
- Trevanion, Stephen J.
- Zerbino, Daniel R.
- Abell, Nathan S.
- Akey, Joshua
- Feinberg, Andrew P.
- Hansen, Kasper D.
- Hickey, Peter F.
- Jiang, Lihua
- Kaul, Rajinder
- Li, Jin Billy
- Li, Qin
- Lin, Shin
- Rizzardi, Lindsay F.
- Skol, Andrew D.
- Smith, Kevin S.
- Snyder, Michael
- Stamatoyannopoulos, John
- Tang, Hua
- Wang, Meng
- Little, A. Roger
- Moore, Helen M.
- Volpi, Simona
- Venue
- Science
- Published
- 2020-09-11
- Volume
- 369
- Issue
- 6509
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8108546
- OpenAlex
- W3084920978
- Cited by
- 515
- References
- 76
- Citations by year
- 2026: 54 · 2025: 90 · 2024: 112 · 2023: 91 · 2022: 87 · 2021: 67 · 2020: 13
- FWCI
- 38.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute on Aging (T32AG000243)
- National Human Genome Research Institute (U01HG007601)
- National Cancer Institute (R01CA107431)
- National Institute of Environmental Health Sciences (R35ES028379-02S1, R35ES028379, R01ES020506)
- Marie-Skłodowska Curie Fellowship H2020 Grant (706636)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- telomere length, telomere shortening, aging
- MeSH terms
- Aging, Genetic Markers, Humans, Organ Specificity, Genetic Variation, Telomere, Telomere Homeostasis, Telomere Shortening
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