A marine microbiome antifungal targets urgent-threat drug-resistant fungi
Open accessAbstract
Prospecting for antifungal molecules: Marine bacteria produce a plethora of natural products that often have unusual chemical structures and corresponding reactivity, which sometimes translate into a valuable biological function. Zhang et al. used a metabolomic screen to zero in on microbial strains from the microbiome of a sea squirt that produces a high diversity of chemical structures. They then screened these molecules for inhibition of fungi (see the Perspective by Cowen). A polycyclic molecule dubbed turbinmicin possessed potent antifungal activity against the multidrug-resistant fungal pathogens Candida auris and Aspergillus fumigatus . Preliminary mechanism-of-action and mouse toxicity studies suggest that this molecule works though a fungus-specific pathway and is well tolerated at therapeutic doses. Science , this issue p. 974 ; see also p. 906
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Turbinmicin is a novel antifungal molecule produced by the associated microbiome of a marine animal.
“The Andes group recently reported on the discovery of a novel antifungal molecule, termed turbinmicin, which interestingly is produced by the associated microbiome of a marine animal [57].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [57]
The fungal vesicle delivery pathway was identified as the target of turbinmicin.
“The fungal vesicle delivery pathway was identified as the target of turbinmicin.”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [57]
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References 66 · Cited by 177
Research works printed but not linked: 1
- [6]Meis JF, Voss A, N. Engl. J. Med 380, 890– 891 (2019). 30811923
- Authors
- Zhang, F., Zhao, M., Braun, D. R., Ericksen, S. S., Piotrowski, J. S., Nelson, J., Peng, J., Ananiev, G. E., Chanana, S., Barns, K., Fossen, J., Sanchez, H., Chevrette, M. G., Guzei, I. A., Zhao, C., Guo, L., Tang, W., Currie, C. R., Rajski, S. R., Audhya, A., Andes, D. R., & Bugni, T. S.
- Affiliations
- University of Wisconsin–Madison (US)
- Yumanity Therapeutics (United States) (US)
- University of Illinois Urbana-Champaign (US)
- Department of Medicine, University of Wisconsin–Madison, Madison, WI, USA.
- Corresponding author
- Zhang, Fan
- Zhao, Miao
- Andes, David R.
- Bugni, Tim S.
- ORCID
- Venue
- Science
- Published
- 2020-11-20
- Volume
- 370
- Issue
- 6519
- Pages
- 974-978
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7756952
- OpenAlex
- W3099535328
- Cited by
- 177
- References
- 66
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 34 · 2023: 32 · 2022: 28 · 2021: 32 · 2020: 4
- FWCI
- 14.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 AI073289, U19 AI109673, U19 AI142720, P41 GM103399, R35 GM134865, R01 GM104192)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- marine microbiome, antifungal natural products, drug-resistant fungi, Candida auris, Aspergillus fumigatus, ascidians, marine bacteria, fungal pathogens, mechanism of action, toxicity
- MeSH terms
- Animals, Antifungal Agents, Benzopyrans, Candida, Disease Models, Animal, Fungal Proteins, Isoquinolines, Micromonospora, Urochordata, Drug Resistance, Multiple, Fungal, Phospholipid Transfer Proteins, Mice, Candidiasis, Invasive, Microbiota
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