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Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ
Open accessAbstract
Tetrameric immune receptors: Nucleotide-binding/leucine-rich repeat (NLR) immune receptors detect pathogen effectors and trigger a plant's immune response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (TIR) domains (TIR-NLRs) (see the Perspective by Tian and Li). Ma et al. studied the Arabidopsis thaliana TIR-NLR RPP1 (recognition of Peronospora parasitica 1) and its response to effectors from an oomycete pathogen. Martin et al. studied the Nicotiana benthamiana TIR-NLR ROQ1 (recognition of XopQ 1) and its response to the Xanthomonas effector. Both groups found that these TIR-NLRs formed tetramers that, when activated by binding to the pathogen effector, exposed the active site of a nicotinamide adenine dinucleoside (NAD) hydrolase. Thus, recognition of the pathogen effector initiates NAD hydrolysis and begins the immune response. Science , this issue p. eabe3069 , p. eabd9993 ; see also p. 1163
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Metadata
- Authors
- Martin, R., Qi, T., Zhang, H., Liu, F., King, M., Toth, C., Nogales, E., & Staskawicz, B. J.
- Venue
- Science
- Published
- 2020-12-04
- Volume
- 370
- Issue
- 6521
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3106552706
- Cited by
- 466
- References
- 6
- FWCI
- 37.60
- Type
- journal article
- Language
- en
- Open access
- green
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