Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

Cited by (516)

Items 301–400 of 516

  1. A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery
    Dora Pinto, Maximilian M. Sauer, Nadine Czudnochowski, Jun Siong Low, M. Alejandra Tortorici, Michael Patrick Housley, Julia Noack, Alexandra C. Walls, John E. Bowen, Barbara Guarino et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  2. Long-Term Immunity and Antibody Response: Challenges for Developing Efficient COVID-19 Vaccines
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  3. Frustration-driven allosteric regulation and signal transmission in the SARS-CoV-2 spike omicron trimer structures: a crosstalk of the omicron mutation sites allosterically regulates tradeoffs of protein stability and conformational adaptability
    Gennady M. Verkhivker, Steve Agajanian, Ryan Kassab, Keerthi Krishnan · 2022 · Physical Chemistry Chemical Physics
  4. Broad and potent neutralizing antibodies are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection
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  5. Escherichia coli recombinant expression of SARS-CoV-2 protein fragments
    Bailey E. McGuire, Julia E. Mela, Vanessa C. Thompson, Logan R. Cucksey, Claire E. Stevens, Ralph L. McWhinnie, Dirk F. H. Winkler, Steven Pelech, Francis E. Nano · 2022 · Microbial Cell Factories
  6. Recent advances in passive immunotherapies for COVID-19: The Evidence-Based approaches and clinical trials
    Pooya Farhangnia, Shiva Dehrouyeh, Amir Reza Safdarian, Soheila Vasheghani Farahani, Melika Gorgani, Nima Rezaei, Mahzad Akbarpour, Ali‐Akbar Delbandi · 2022 · International Immunopharmacology
  7. Ultrapotent and broad neutralization of SARS-CoV-2 variants by modular, tetravalent, bi-paratopic antibodies
    Shane Miersch, Nitin Sharma, Reza Saberianfar, Chao Chen, Francesca Caccuri, Alberto Zani, Arnaldo Caruso, James Brett Case, Michael Diamond, Gaya K. Amarasinghe et al. · 2022 · Cell Reports
  8. Analysis of SARS-CoV-2 spike glycosylation reveals shedding of a vaccine candidate
    Juliane Brun, Snežana Vasiljević, Bevin Gangadharan, Mario Hensen, Anu V. Chandran, Michelle L. Hill, J. L. Kiappes, Raymond Allen Dwek, Dominic S. Alonzi, Weston B. Struwe et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  9. Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines
    Simone Pecetta, Sven Kratochvil, Yu Kato, Kumaran Vadivelu, Rino Rappuoli · 2022 · Pharmacological Reviews
  10. Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model
    Maya Imbrechts, Wim Maes, Louanne Ampofo, Nathalie Van den Berghe, Bas Calcoen, Dominique Van Looveren, Winnie Kerstens, Madina Rasulova, Thomas Vercruysse, Sam Noppen et al. · 2022 · iScience
  11. A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 Mice
    Pascal Brandys, Xavier Montagutelli, Irena Merenkova, G. Tuba Barut, Volker Thiel, Nicholas J. Schork, Bettina Salome Trüeb, Laurine Conquet, Aihua Deng, Aleksandar Antanasijevic et al. · 2022 · Frontiers in Immunology
  12. Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD
    Hui Sun, Tingting Deng, Yali Zhang, Yanling Lin, Yanan Jiang, Yichao Jiang, Yang Huang, Shuo Song, Lingyan Cui, Tingting Li et al. · 2023 · Protein & Cell
  13. Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates
    Paule Hermet, Benoît Delache, Cécile Hérate, Esther Wolf, Gaily Kivi, Erkki Juronen, Karl Mumm, Eva Žusinaite, Denis E. Kainov, Eve Sankovski et al. · 2023 · PLoS Pathogens
  14. Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants
    Yuanyuan Qu, Xueyan Zhang, Meiyu Wang, Lina Sun, Yongzhong Jiang, Cheng Li, Wei Wu, Zhen Chen, Qiangling Yin, Xiaolin Jiang et al. · 2021 · Virologica Sinica
  15. An Antigenic Space Framework for Understanding Antibody Escape of SARS-CoV-2 Variants
    Nathaniel L. Miller, Thomas Clark, Rahul Raman, Ram Sasisekharan · 2021 · Viruses
  16. Contributions of single-particle cryoelectron microscopy toward fighting COVID-19
    Micah Rapp, Lawrence S. Shapiro, Joachim Frank · 2021 · Trends in Biochemical Sciences
  17. Neutralizing Antibodies Against Allosteric Proteins: Insights From a Bacterial Adhesin
    Evgeni V. Sokurenko, Veronika L Tchesnokova, Gianluca Interlandi, Rachel E. Klevit, Wendy E. Thomas · 2022 · Journal of Molecular Biology
  18. A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern
    Hilal Ahmad Parray, Naveen Narayanan, Sonal Garg, Zaigham Abbas Rizvi, Tripti Shrivastava, Sachin Kushwaha, Janmejay Singh, Praveenkumar Murugavelu, Anbalagan Anantharaj, Farha Mehdi et al. · 2022 · PLoS Pathogens
  19. SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes
    Steven C. Wall, Naveenchandra Suryadevara, Changil Kim, Andrea R. Shiakolas, Clinton Holt, Emma B. Irbe, Perry T. Wasdin, Yukthi P. Suresh, Elad Binshtein, Elaine C. Chen et al. · 2023 · Cell Reports Medicine
  20. SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise
    Ralf Duerr, Keaton M. Crosse, Ana M. Valero-Jimenez, Meike Dittmann · 2021 · Microorganisms
  21. Unravelling the molecular interactions between the SARS-CoV-2 RBD spike protein and various specific monoclonal antibodies
    Didac Martí, Marc Alsina, Carlos Alemán, Oscar Bertrán, Pau Turón, Juan Torras · 2021 · Biochimie
  22. Monoclonal Antibodies as Potential COVID-19 Therapeutic Agents
    Jacek Plichta, Piotr Kuna, Michał Panek · 2022 · COVID
  23. Impacts on the structure-function relationship of SARS-CoV-2 spike by B.1.1.7 mutations
    Tzu‐Jing Yang, Pei‐Yu Yu, Yuan‐Chih Chang, Kang-Hao Liang, Hsian-Cheng Tso, Meng‐Ru Ho, Chen Wy, Hsiu-Ting Lin, Han‐Chung Wu, Shang‐Te Danny Hsu · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  24. A high-throughput, automated, cell-free expression and screening platform for antibody discovery
    Andrew C. Hunt, Bastian Vögeli, Weston Kightlinger, Danielle J. Yoesep, Antje Krüger, Michael C. Jewett · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  25. An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike
    Banghui Liu, Xuefeng Niu, Yijun Deng, Zhaoyong Zhang, Yanqun Wang, Xijie Gao, Huan Liang, Zimu Li, Qian Wang, Yuanyi Cheng et al. · 2024 · Cell Reports
  26. Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base
    Sieglinde De Cae, Inge Van Molle, Loes van Schie, Sophie R. Shoemaker, Julie Deckers, Nincy Debeuf, Sahine Lameire, Wim Nerinckx, Kenny Roose, Daria Fijałkowska et al. · 2025 · Nature Communications
  27. Atomistic Simulations and In Silico Mutational Profiling of Protein Stability and Binding in the SARS-CoV-2 Spike Protein Complexes with Nanobodies: Molecular Determinants of Mutational Escape Mechanisms
    Gennady M. Verkhivker, Steve Agajanian, Deniz Yaşar Öztaş, Grace Gupta · 2021 · ACS Omega
  28. Circulation of SARS-CoV-2 Variants among Children from November 2020 to January 2022 in Trieste (Italy)
    Maria Dolci, Lucia Signorini, Carolina Cason, Giuseppina Campisciano, Paolo Kunderfranco, Elena Pariani, Cristina Galli, Vincenzo Petix, Pasquale Ferrante, Serena Delbue et al. · 2022 · Microorganisms
  29. Quantitation of SARS-CoV-2 neutralizing antibodies with a virus-free, authentic test
    Johannes Roessler, Dagmar Pich, Manuel Albanese, Paul R. Wratil, Verena Krähling, Johannes C. Hellmuth, Clemens Scherer, Michael von Bergwelt‐Baildon, Stephan Becker, Oliver Till Keppler et al. · 2022 · PNAS Nexus
  30. Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike protein
    Carlos Costa, Arménio Jorge Moura Barbosa, Ana Margarida Gonçalves Carvalho Dias, Ana Cecília A. Roque · 2022 · Biotechnology Advances
  31. Structural insights into SARS-CoV-2 infection and therapeutics development
    Gangyu Sun, Lulu Xue, Qingjing He, Yue Zhao, Wenqing Xu, Zhizhi Wang · 2021 · Stem Cell Research
  32. An anti-SARS-CoV-2 non-neutralizing antibody with Fc-effector function defines a new NTD epitope and delays neuroinvasion and death in K18-hACE2 mice
    G. Beaudoin-Bussières, Yao-Zong Chen, Irfan Ullah, Jérémie Prévost, W. Tolbert, K. Symmes, Shi-Lei Ding, M. Benlarbi, S. Gong, A. Tauzin et al. · 2021 · bioRxiv
  33. Preclinical animal models to evaluate therapeutic antiviral antibodies
    Amse De Meyer, Philip Meuleman · 2024 · Antiviral Research
  34. Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses
    Megi Rexhepaj, Daniel E. Asarnow, Lisa Perruzza, Young‐Jun Park, Barbara Guarino, Mathew Mccallum, Katja Culap, Christian Saliba, Giada Leoni, Alessio Balmelli et al. · 2024 · Immunity
  35. Public antibodies: convergent signatures in human humoral immunity against pathogens
    Vishal N. Rao, Camila H. Coelho · 2025 · mBio
  36. Allosteric Determinants of the SARS-CoV-2 Spike Protein Binding with Nanobodies: Examining Mechanisms of Mutational Escape and Sensitivity of the Omicron Variant
    Gennady M. Verkhivker · 2022 · International Journal of Molecular Sciences
  37. Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence
    Kathryn M. Hastie, Xiaoying Yu, Fernanda Ana‐Sosa‐Batiz, Dawid S. Zyla, Stephanie Harkins, Chitra Hariharan, Hal Wasserman, Michelle A. Zandonatti, Robyn Miller, Erin Maule et al. · 2023 · Cell Reports
  38. Nanobodies with cross-neutralizing activity provide prominent therapeutic efficacy in mild and severe COVID-19 rodent models
    Qiuxue Han, Shen Wang, Zhenshan Wang, Cheng Zhang, Xinyue Wang, Na Feng, Tiecheng Wang, Yongkun Zhao, Hang Chi, Feihu Yan et al. · 2023 · Virologica Sinica
  39. Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features
    Hao D. Cheng, Karen G. Dowell, Chris Bailey‐Kellogg, Brittany A. Goods, John Christopher Love, Guido Ferrari, Galit Alter, Johannes S. Gach, Donald N. Forthal, George K. Lewis et al. · 2021 · Retrovirology
  40. Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19–convalescent individuals
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  41. Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects macaques from infection
    Guidenn Sulbarán, Pauline Maisonnasse, Axelle Amen, Grégory Effantin, Delphine Guilligay, Nathalie Dereuddre‐Bosquet, Judith A. Burger, Meliawati Poniman, Marloes Grobben, Marlyse Buisson et al. · 2022 · Cell Reports Medicine
  42. Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus
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  43. Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants
    Hyeseong Cho, K. K. Gonzales-Wartz, De-Li Huang, M. Yuan, M. Peterson, Janie Y. Liang, N. Beutler, J. Torres, Yu Cong, E. Postnikova et al. · 2021 · bioRxiv
  44. Integrating Conformational Dynamics and Perturbation-Based Network Modeling for Mutational Profiling of Binding and Allostery in the SARS-CoV-2 Spike Variant Complexes with Antibodies: Balancing Local and Global Determinants of Mutational Escape Mechanisms
    Gennady M. Verkhivker, Steve Agajanian, Ryan Kassab, Keerthi Krishnan · 2022 · Biomolecules
  45. Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses
    Mikhail Y. Lebedin, Christoph Ratswohl, Amar Kumar Garg, Marta Schips, Clara Vázquez García, Lisa Spatt, Charlotte Thibeault, Benedikt Obermayer, January Mikolaj Weiner, Ilais Moreno Velásquez et al. · 2024 · iScience
  46. Neutralisation resistance of SARS-CoV-2 spike-variants is primarily mediated by synergistic receptor binding domain substitutions
    Long V. Pham, Alexander P. Underwood, Alekxander Binderup, Ulrik Fahnøe, Carlota Fernandez-Antunez, Blanca Lopez Mendez, Line Abildgaard Ryberg, Andrea Galli, Christina Søhoel Sølund, Nina M Weis et al. · 2024 · Emerging Microbes & Infections
  47. Biochemical Interface Engineering for Transistor-Based Point-of-Care Diagnostics
    Derong Kong, Zhenzhen Xu, Chang Qing Chen, Yunqi Liu, Dacheng Wei · 2026 · Accounts of Chemical Research
  48. Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins
    Zeeshan Ali, Jyothsna Volisha Cardoza, Srijita Basak, Utkarsh Narsaria, Vijay Pratap Singh, Samuel Paul Isaac, Tanos C. C. França, Steven R. LaPlante, Sudhan sunderasion george · 2023 · Journal of Biomolecular Structure and Dynamics
  49. Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi
    Michael J. Rudolph, Simon A. Davis, H. M. Emranul Haque, David D. Weis, David J. Vance, Carol Lyn Piazza, Monir Ejemel, Lisa A. Cavacini, Yang Wang, M. Lamine Mbow et al. · 2023 · mBio
  50. Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity
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  51. Prevalence and Main Clinical Characteristics of Fully Vaccinated Patients Admitted to Hospital for Delta Variant COVID-19
    Matteo Vassallo, Nicolas Clement, Laurène Lotte, Sabrina Manni, Audrey Sindt, Pierre Marie Bertrand, Jacques Durant · 2022 · Frontiers in Medicine
  52. Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies
    Daria Beshnova, Yan Fang, Mingjian Du, Yehui Sun, Fenghe Du, Jianfeng Ye, Zhijian J. Chen, Bo Li · 2022 · Computational and Structural Biotechnology Journal
  53. Discovery of Natural Lead Compound from Dendrobium sp. against SARS-CoV-2 Infection
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  54. Chronic shedding of a SARS-CoV-2 Alpha variant in wastewater
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  55. SARS-CoV-2 Omicron variations reveal mechanisms controlling cell entry dynamics and antibody neutralization
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  56. Potent neutralizing RBD‐specific antibody cocktail against SARS‐CoV‐2 and its mutant
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  57. Antibody attributes that predict the neutralization and effector function of polyclonal responses to SARS-CoV-2
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  58. Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects
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  59. A large-scale systematic survey of SARS-CoV-2 antibodies reveals recurring molecular features
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  60. Absolute concentration estimation of COVID-19 convalescent and post-vaccination IgG antibodies
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  61. Integrative Computational Modeling of Distinct Binding Mechanisms for Broadly Neutralizing Antibodies Targeting SARS-CoV-2 Spike Omicron Variants: Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune Escape
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  62. A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants
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  63. Designing and bioengineering of CDRs with higher affinity against receptor-binding domain (RBD) of SARS-CoV-2 Omicron variant
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  64. In silico analysis suggests less effective MHC-II presentation of SARS-CoV-2 RBM peptides: Implication for neutralizing antibody responses
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  65. Comirnaty-Elicited and Convalescent Sera Recognize Different Spike Epitopes
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  66. Continued Virus-Specific Antibody-Secreting Cell Production, Avidity Maturation and B Cell Evolution in Patients Hospitalized with COVID-19
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  67. Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody Reactivity
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  68. Thermodynamics and kinetics in antibody resistance of the 501Y.V2 SARS-CoV-2 variant
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  69. Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2
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  70. Tracking the immune response profiles elicited by the BNT162b2 vaccine in COVID-19 unexperienced and experienced individuals
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  71. Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters
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  72. Immunotherapy and CRISPR Cas Systems: Potential Cure of COVID-19?
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  73. A SARS–CoV-2 Spike Receptor Binding Motif Peptide Induces Anti-Spike Antibodies in Mice andIs Recognized by COVID-19 Patients
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  74. Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern
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  75. Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation
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  76. Variation in structural motifs within SARS-related coronavirus spike proteins
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  77. Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection
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  78. Kinetics of Neutralizing Antibody Response Underscores Clinical COVID-19 Progression
    Qing Lei, Hongyan Hou, Caizheng Yu, Yandi Zhang, Jo‐Lewis Banga Ndzouboukou, Xiaosong Lin, Zongjie Yao, Hui Fu, Sun Ziyong, Feng Wang et al. · 2021 · Journal of Immunology Research
  79. A recurring YYDRxG pattern in broadly neutralizing antibodies to a conserved site on SARS-CoV-2, variants of concern, and related viruses
    Hejun Liu, Chengzi I. Kaku, Ge Song, Meng Yuan, Raiees Andrabi, Dennis R. Burton, Laura M. Walker, Ian A. Wilson · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  80. Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2
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  81. Dynamic mutational profiling of binding interactions and allosteric networks in conformational ensembles of the SARS-CoV-2 spike protein complexes with classes of antibodies targeting cryptic binding sites: confluence of binding and allostery determines molecular mechanisms and hotspots of immune escape
    Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker · 2025 · Physical Chemistry Chemical Physics
  82. 501Y.V2 spike protein resists the neutralizing antibody in atomistic simulations
    Sơn Tùng Ngô · 2022 · Computational Biology and Chemistry
  83. Conformational Flexibility and Local Frustration in the Functional States of the SARS-CoV-2 Spike B.1.1.7 and B.1.351 Variants: Mutation-Induced Allosteric Modulation Mechanism of Functional Dynamics and Protein Stability
    Gennady M. Verkhivker · 2022 · International Journal of Molecular Sciences
  84. Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant
    Hui Sun, Yizhen Wang, Xiuting Chen, Yanan Jiang, Siling Wang, Yang Huang, Liqin Liu, Li Yu, Miaolin Lan, Huilin Guo et al. · 2023 · Journal of Virology
  85. Characterization of a neutralizing antibody that recognizes a loop region adjacent to the receptor-binding interface of the SARS-CoV-2 spike receptor-binding domain
    Itsuki Anzai, Junso Fujita, Chikako Ono, Yoichiro Kosaka, Yuki Miyamoto, Shintaro Shichinohe, Kosuke Takada, Shiho Torii, Shuhei Taguwa, Koichiro Suzuki et al. · 2024 · Microbiology Spectrum
  86. S309-CAR-NK cells bind the Omicron variants in vitro and reduce SARS-CoV-2 viral loads in humanized ACE2-NSG mice
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  87. Protective Non-neutralizing anti–N-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence
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  88. Predicting spike protein NTD mutations of SARS-CoV-2 causing immune evasion by molecular dynamics simulations
    Liping Zhou, Leyun Wu, Cheng Peng, Yanqing Yang, Yulong Shi, Likun Gong, Zhijian Xu, Weiliang Zhu · 2022 · Physical Chemistry Chemical Physics
  89. Diagnostic Value of a SARS-CoV-2 Rapid Test Kit for Detection of Neutralizing Antibodies as a Point-of-Care Surveillance Test
    Michele Mun Hei Chan, Ka‐Yi Leung, Ricky Rui Qi Zhang, Danlei Liu, Yujing Fan, Matthew Ka Wa Khong, Anthony Raymond Tam, Honglin Chen, Kwok-Yung Yuen, Ivan Fan‐Ngai Hung et al. · 2022 · Microbiology Spectrum
  90. SARS-CoV-2 Antibody Effectiveness Is Influenced by Non-Epitope Mutation/Binding-Induced Denaturation of the Epitope 3D Architecture
    Moffat M. Malisheni, Matthew Bates, Albert Anatolyevich Rizvanov, Paul A. MacAry · 2022 · Pathogens
  91. Homology Modeling of Antibody Variable Regions: Methods and Applications
    Harsh Bansia, Suryanarayanarao Ramakumar · 2023 · Methods in molecular biology
  92. Changes of peripheral lymphocyte subset in patients with SARS-CoV-2 infection during the whole course of disease
    Xingxia Yu, Rongrong Yang · 2020 · Expert Review of Respiratory Medicine
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