Oncolytic virotherapy as immunotherapy
Open accessAbstract
Recognizing immune responses to oncolytic virotherapy opens the way for new combinations
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Oncolytic viruses can lead to induction of an adaptive immune response by releasing tumour and viral antigens from dying cancer cells.
“But, even more important, they can lead to the induction of an adaptive immune response by releasing tumour and viral antigens from dying cancer cells.127”
From Current and emerging concepts for systemic treatment of metastatic colorectal cancer (2025) · cites this paper as [127]
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References 16 · Cited by 133
Research works printed but not linked: 2
- [3]Garcia-Carbonero R, J. Immunother. Cancer 5, 71 (2017). 28923104 PMC5604344
- [6]Paz-Ares L N. Engl. J. Med 379, 2040 (2018). 30207915
- Authors
- Melcher, A., Harrington, K., & Vile, R.
- Affiliations
- Institute of Cancer Research (GB)
- Mayo Clinic (US)
- Venue
- Science
- Published
- 2021-12-10
- Volume
- 374
- Issue
- 6573
- Pages
- 1325-1326
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8961675
- OpenAlex
- W4200413360
- Cited by
- 133
- References
- 16
- Citations by year
- 2026: 18 · 2025: 31 · 2024: 36 · 2023: 30 · 2022: 18
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R21CA262994)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- oncolytic virotherapy, immunotherapy, combination therapy, tumor immunology
- MeSH terms
- Antineoplastic Agents, Immunological, Animals, Combined Modality Therapy, Humans, Immunotherapy, Neoplasms, Randomized Controlled Trials as Topic, Oncolytic Virotherapy, Oncolytic Viruses
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