Cited by 133Virus-based gene therapy researchImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Oncolytic virotherapy as immunotherapy

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Melcher, Alan, Harrington, Kevin, Vile, Richard·2021·Science

Abstract

Recognizing immune responses to oncolytic virotherapy opens the way for new combinations

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Crossref · 10.1126/science.abk3436

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  • Oncolytic viruses can lead to induction of an adaptive immune response by releasing tumour and viral antigens from dying cancer cells.

    “But, even more important, they can lead to the induction of an adaptive immune response by releasing tumour and viral antigens from dying cancer cells.127”

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References 16 · Cited by 133

Research works printed but not linked: 2

  1. [3]Garcia-Carbonero R, J. Immunother. Cancer 5, 71 (2017). 28923104 PMC5604344
  2. [6]Paz-Ares L N. Engl. J. Med 379, 2040 (2018). 30207915

Authors
Melcher, A., Harrington, K., & Vile, R.
Affiliations
  • Institute of Cancer Research (GB)
  • Mayo Clinic (US)
Venue
Science
Published
2021-12-10
Volume
374
Issue
6573
Pages
1325-1326
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W4200413360
Cited by
133
References
16
Citations by year
2026: 18 · 2025: 31 · 2024: 36 · 2023: 30 · 2022: 18
FWCI
11.87
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R21CA262994)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
oncolytic virotherapy, immunotherapy, combination therapy, tumor immunology
MeSH terms
Antineoplastic Agents, Immunological, Animals, Combined Modality Therapy, Humans, Immunotherapy, Neoplasms, Randomized Controlled Trials as Topic, Oncolytic Virotherapy, Oncolytic Viruses

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