Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
Open accessPublished version of a preprint
Abstract
The effectiveness of vaccines against COVID-19 on the individual level is well established. However, few studies have examined vaccine effectiveness against transmission. We used a chain binomial model to estimate the effectiveness of vaccination with BNT162b2 [Pfizer-BioNTech messenger RNA (mRNA)-based vaccine] against household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Israel before and after emergence of the B.1.617.2 (Delta) variant. Vaccination reduced susceptibility to infection by 89.4% [95% confidence interval (CI): 88.7 to 90.0%], whereas vaccine effectiveness against infectiousness given infection was 23.0% (95% CI: −11.3 to 46.7%) during days 10 to 90 after the second dose, before 1 June 2021. Total vaccine effectiveness was 91.8% (95% CI: 88.1 to 94.3%). However, vaccine effectiveness is reduced over time as a result of the combined effect of waning of immunity and emergence of the Delta variant.
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This suggests a transmission reduction effect of prior immunity, in line with other findings.
“Vaccine breakthroughs and reinfections were 41% less likely to transmit than primary infections (odds ratio 0.59, 95% CI 0.46-0.73),suggesting a transmission reduction effect of prior immunity, in line with other findings 12 .”
From Rapidly shifting immunologic landscape and severity of SARS-CoV-2 in the Omicron era in South Africa (2023) · cites this paper as [12]
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References 35 · Cited by 153
Research works printed but not linked: 2
- [5]V. Shah., Effect of vaccination on transmission of COVID-19: an observational study in healthcare workers and their households. medRxiv, 2021: p. 2021.03.11.21253275.
- [20]T. Patalon., Short Term Reduction in the Odds of Testing Positive for SARS-CoV-2; a Comparison Between Two Doses and Three doses of the BNT162b2 Vaccine. medRxiv, 2021.
- Authors
- Prunas, O., Warren, J. L., Crawford, F. W., Gazit, S., Patalon, T., Weinberger, D. M., & Pitzer, V. E.
- Affiliations
- Yale University (US)
- Maccabi Healthcare Services (IL)
- Corresponding author
- Prunas, Ottavia
- ORCID
- Venue
- Science
- Published
- 2022-03-11
- Volume
- 375
- Issue
- 6585
- Pages
- 1151-1154
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC9261115
- OpenAlex
- W4220836043
- Cited by
- 153
- References
- 35
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 13 · 2023: 42 · 2022: 69 · 2021: 15
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Science (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (UL1TR001863)
- National Institute of Allergy and Infectious Diseases (R01AI112970, R01AI137093)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (DP2HD091799)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- BNT162b2, COVID-19 pandemic, SARS-CoV-2, household transmission, vaccine effectiveness, infectiousness, Delta variant, waning immunity, mRNA vaccines, Israel
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