The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants
Open accessAbstract
How the Delta variant evades defenses: In the course of the COVID-19 epidemic, variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge, some of which evade immunity or increase transmission. In late 2020, the Delta and Kappa variants were detected, and the Delta variant became globally dominant by June 2021. McCallum et al . show that vaccine-elicited serum-neutralizing activity is reduced against these variants. Based on biochemistry and structural studies, the authors show that mutations in the domain that binds the ACE2 receptor abrogate binding to some monoclonal antibodies but do not improve ACE2 binding, suggesting that they emerged to escape immune recognition. Remodeling of the N-terminal domain allows the variants to escape recognition by most neutralizing antibodies that target it. The work could guide the development of next-generation vaccines and antibody therapies. —VV
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Cited by
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
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Self-citationStructural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement
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Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains
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Metadata
- Authors
- McCallum, M., Walls, A. C., Sprouse, K. R., Bowen, J. E., Rosen, L. E., Dang, H. V., De Marco, A., Franko, N., Tilles, S. W., Logue, J., Miranda, M. C., Ahlrichs, M., Carter, L., Snell, G., Pizzuto, M. S., Chu, H. Y., Van Voorhis, W. C., Corti, D., & Veesler, D.
- Venue
- Science
- Published
- 2021-12-24
- Volume
- 374
- Issue
- 6575
- Pages
- 1621-1626
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3214683033
- Cited by
- 288
- References
- 45
- FWCI
- 19.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- McCallum, M., Walls, A. C., Sprouse, K. R., Bowen, J. E., Rosen, L. E., Dang, H. V., De Marco, A., Franko, N., Tilles, S. W., Logue, J., Miranda, M. C., Ahlrichs, M., Carter, L., Snell, G., Pizzuto, M. S., Chu, H. Y., Van Voorhis, W. C., Corti, D., & Veesler, D. (2021). Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants. Science. https://doi.org/10.1126/science.abl8506
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
