Is taurine an aging biomarker?
Abstract
Low circulating taurine concentrations have been proposed as a driver of the aging process. We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman primates and mice when measured longitudinally (repeatedly in the same population) or cross-sectionally (sampling distinct populations at various ages). Moreover, considerable variability was observed in associations between taurine and age-related changes in health outcomes pertaining to gross motor function and energy homeostasis. Our results suggest that changes in circulating taurine are not a universal feature of aging and that its pleiotropic effects may be dependent on the temporal and physiological context of each individual.
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Prior work typically centrifuged blood at 17,000-20,000 × g to obtain plasma or serum; these high forces may compromise cell integrity and thereby contribute to potential variability across studies.
“Unlike our studies, prior work typically centrifuged blood at 17,000–20,000 × g to obtain plasma or serum4,73; these high forces may compromise cell integrity and thereby contribute to potential variability across studies.”
From Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages (2026) · cites this paper as [4]
Cites
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Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages
Guan, C., Ryu, S., Dong, M., Zhu, Y., Maeda, R., Youm, Y.-H., Mohanty, S., Kim, H.-H., Orliaguet, L., Dlugos, T., et al. (2026) · Cell · doi:10.1016/j.cell.2026.09.061
- Authors
- Fernandez, M. E., Bernier, M., Price, N. L., Camandola, S., Aon, M. A., Vaughan, K., Mattison, J. A., Preston, J. D., Jones, D. P., Tanaka, T., Tian, Q., González-Freire, M., Ferrucci, L., & de Cabo, R.
- Affiliations
- Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health (NIH), Baltimore, MD, USA.
- National Institutes of Health (US)
- Emory University (US)
- Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain.
- ORCID
- Venue
- Science
- Published
- 2025-06-05
- Volume
- 388
- Issue
- 6751
- Pages
- eadl2116-eadl2116
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4411051405
- Cited by
- 33
- References
- 5
- Citations by year
- 2026: 25 · 2025: 8
- FWCI
- 16.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- taurine, aging, aging biomarkers, longitudinal cohort, non-human primates, mice, gross motor function, energy homeostasis, pleiotropy
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Animals, Cross-Sectional Studies, Energy Metabolism, Female, Humans, Longitudinal Studies, Male, Mice, Inbred C57BL, Middle Aged, Taurine, Biomarkers, Mice
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