Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

Varanasi, Siva Karthik, Chen, Dan, Liu, Yingluo, Johnson, Melissa A., Miller, Cayla M., Ganguly, Souradipta, Lande, Kathryn, LaPorta, Michael A. +25 more·2025·Science

DOI 10.1126/science.adl4100

Cited by (174)

Items 101–174 of 174

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Immune cytokines as a bridge linking the gut–liver–ovary axis in the pathogenesis of premature ovarian failure
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Gut microbial metabolites for potentiating cancer therapy
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Bile acid species as hepatic T lymphocyte response modulators – when bile acids interfere with tumor growth
David C. Trampert · 2025 · Journal of Hepatology
Single-cell RNA sequencing and spatial transcriptomic analysis reveal a distinct population of G6PD+ cells with aberrant bile acid metabolism in hepatocellular carcinoma
Xing Jiang, Haiyan Quan, Ting Yin, Hailun Yao, Yajun Li, Bin Peng, Xinye Yuan, Weiguang Zeng, Honghui Chen, Rong Li · 2026 · Frontiers in Immunology
Harnessing the gut microbiota to enhance immune checkpoint inhibitor efficacy: from mechanistic insights to clinical translation
Qinsheng Bi, L Zhang, Hejia Wan, Jiaxin Zhang · 2026 · Molecular Biology Reports
Resveratrol Alleviates Arsenic-Induced Liver Fibrosis in Rats by Correcting SIRT1-Mediated Disorder of Hepatic Bile Acid Metabolism
Qi Wang, Hualin Chen, Qiming Ran, Fang Hu, Qiwen Fu, Lu Ma · 2026 · International Journal of Molecular Sciences
Bile Acids and Healthy Ageing
Brecht J. Attema, Folkert Kuipers · 2026 · Engineering
Molecular insights into early malignant transition of hepatocellular carcinoma
Zhengtao Zhang, Hong Li, Ling-Li Chen, Tao Lu, Xinyi Shentu, Yuan-Hua Liu, S. Ji, Zhixin Qiu, Yi-Ning Zou, Hong-Lin Wen et al. · 2025 · bioRxiv
A translational model of MASLD-associated HFpEF defines mitochondrial dysfunction and cardiac plasticity during disease progression and regression
Souradipta Ganguly, Betul Beyza Gunes, Yusu Gu, Jorge Suárez, Gautam Gupta, Kei Ishizuka, Rabi Murad, Tatiana Kisseleva, Wolfgang H. Dillmann, Kirk L. Peterson et al. · 2026 · Metabolism
Advances in bile acid metabolism-mediated immunomodulation
Lu BAI, Fang Yang, Leng HAN, Cheng GUO, Quan-Jun YANG · 2026 · Shengming kexue
Bile acid metabolism and invasion-related genes as therapeutic monitoring biomarkers in non-small cell lung cancer
Guangteng Wu, Lin Zhu, Feng Xue, Yanyi Zhao · 2025 · Discover Oncology
Screening of known gut microbiome-derived metabolites in anti-tumor immunity of colorectal cancer
Xinan Zhang, Zixuan Li, Hui Hua, Hao Song, Sangni Qian, Xin Huang, Guiqin Ye, Yingyu Huang, Qin Wang, Boan Zheng et al. · 2026 · Journal for ImmunoTherapy of Cancer
Lenvatinib Combined with PD-1 Blockade Therapy Benefits Gastric Cancers through Immunosuppressive Macrophage Modulation
Yi-Tzu Lin, Hirotomo Machiyama, Akihito Kawazoe, Atsuo Sai, Takuma Irie, Takumi Habu, Shota Fukuoka, Atsushi Kumanogoh, Naoya Sakamoto, Genichiro Ishii et al. · 2026 · Cancer Immunology Research
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao · 2026 · MedComm – Oncology
Deoxycholic acid impairs mitochondrial fitness and suppresses mitophagy through Parkin ubiquitination driving CD8+ T cell Exhaustion in Colorectal Cancer
Gao Y, Jiaxin Wang, Shihui Lai, Mingwei Li, Shi Jl, Xianjun Li, Ying Guo, Sainan Ma, Xinxin Wang, Shule Zhang et al. · 2026 · Redox Biology
Click chemistry approach to bioactive conjugates of bile acids and sterols
Anna Kawka, Hanna Koenig, Tomasz Pospieszny · 2026 · Studies in natural products chemistry
Bile acids and bile acid modification in health and disease: from novel modifications to therapeutic interventions
Chuying Yu, Xintong Ye, Haoyu Zhao, 钱素婷, Feifei Xie, Qingsheng Liu · 2026 · Frontiers in Endocrinology
A new incompatible combination: Reynoutria multiflora combined with Cullen corylifolium enhances idiosyncratic hepatotoxicity under immunological stress
2025
Discovery and Validation of COL11A1 as a Therapeutic Target for Sorafenib Resistance in Lung Adenocarcinoma
2026
The interplay between lipid metabolism, cancer progression and anti-cancer immunity
Choong‐Hyun Koh, Yoosun Lee, Il‐Kyu Kim, Yeonseok Chung · 2026 · Experimental & Molecular Medicine
The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism
Jöerg Heeren, Ioannis Evangelakos, Esther Verkade, Folkert Kuipers, Julia Sarah Rohde, Markus Heine, Anna Worthmann, Sebastian Graute, Manka M. Fuh, Karthikeyan Gunasekaran et al. · 2025 · Research Square
Chenodeoxycholic acid restrains tumor growth via TGR5-dependent type 1 dendritic cells cross-priming
Fanlian Zeng, Fulei Zhao, Pei Zhou, Ya Li, Xiaoyan Wang, Yawen Hu, Jiadong Yu, Guolin Li, Chengcheng Yue, Yuting Feng et al. · 2026 · Signal Transduction and Targeted Therapy
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Tareq Nayef AlRamadneh, Jasur Rizaev, Malathi Hanumanthayya, Maryam Abdul Al-Hussein, Ahmed Faisal Mutee, Mukhammadali Buriev, Nasiba Jumaniyazova, Shefali · 2026 · Frontiers in Microbiology
On the use of UDCA beyond cholestatic liver disease: How bile acid-driven intestinal GLP-1 signalling keeps the joints healthy
David C. Trampert · 2026 · Journal of Hepatology
Beyond Insulin Resistance: Exploring the Centrality of the Gut–Liver Axis in Mediating Immunometabolic Dysregulation Driving Hepatocellular Carcinoma in MASLD and Diabetes
Mario Romeo, Claudio Basile, Giuseppina Martinelli, Fiammetta Di Nardo, Carmine Napolitano, Alessia De Gregorio, Paolo Vaia, Luigi Di Puorto, Mattia Indipendente, Alessandro Federico et al. · 2026 · Cancers
Chemical dissection of sterol and bile acid signaling via clickable photoaffinity probes
Miaomiao Xu, Xiaoming Chen, Jian Ma, Xinglin Yang · 2025 · Biophysics Reports
Mechanisms and Clinical Significance of Bile Acid Metabolism Reprogramming in Hepatocellular Carcinoma Immunotherapy Response
Tianmin Zhou, Ruixin Wang, Hao Wei, Wenli Liu, Yingqun Xiao, Qingmei Zhong, Zhuoqi Liu, Daya Luo, Kunpeng Jiang, Ping Zhang et al. · 2026 · Research Square
Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tao Wang, Chen Xue, Lanjuan Li · 2026 · MedComm
Functionalized nanopipettes for pH-gated single cell DNA delivery
2025
TBA-MLR score: a metabolic-immune prognostic biomarker for postoperative hepatocellular carcinoma
Yuanquan Zhao, Wei Huang, Xiwen Deng, Pengyang Li, Siyang Yao, Yongyu Yang, Xiaofeng Dong · 2025 · Frontiers in Immunology
Hepatocellular carcinoma tumor immune microenvironment: heterogeneity and therapeutic strategies
Taishun Mao, Junqing Jiang, Ping Liu, Yongxiang Zhao, Liping Zhong, Zerui Zhang, Kaichun Wu, Limin Xia · 2026 · Hepatoma Research
Lithocholic acid-activated VDR in macrophages promotes HCC recurrence post-ablation via SOCS3-mediated suppression of CXCL16
Rumei Li, Wanrong Luo, Zhaoxi Li, Sui Zheng, Man Luo, Qiuxia Wei, Xiaotong Zhu, Wenyue Zhang, Baoming Luo · 2026 · Journal for ImmunoTherapy of Cancer
Comparative analysis of lipid-lowering mechanisms in efficacy-divergent traditional Chinese medicines
2026
Research Progress of PCSK9 and Its Inhibitors in the Treatment of Hepatocellular Carcinoma
亚峰刘 · 2026 · Pharmacy Information
Multi-omics profiling reveals cholic acid-mediated immunosuppression driven by peritumoral ductular reactions in hepatocellular carcinoma
Qianhui Xu, Hang Chen, Ganggang Wang, Xiaodong Wang, JieYi Shi, Yifei Cheng, Yanan Xu, Sainan Ma, Siqi Guo, Xiyang Liu et al. · 2026 · Cancer Letters
Decoding the Biological Function of Bile Acids for Drug Discovery
Jun Yang, Xiaoguang Lei · 2026 · Accounts of Chemical Research
Inhibition of bile acid conjugation improves cholestatic liver injury in mice with a humanized bile acid pool
Claudia Daniela Fuchs, Oleksandr Petrenko, Veronika Mlitz, Emmanuel Dauda Dixon, Hubert Scharnagl, Ahmed Ghallab, Thomas Reiberger, Benjamin P. Garfinkel, Michael A Trauner · 2026 · npj gut and liver.
Iron exacerbates congenital cholestatic liver injury via bile acid-induced ferroptosis
Toshiro Moroishi, Yudai Ohta, Yohei Kanamori, Ayato Maeda, Mohammad Saleh, Akihiro Nita, Takashi Matsumoto, Keiichi I. Nakayama · 2025 · Research Square
Gut microbiota-metabolism-immunity axis: a novel perspective of traditional Chinese medicine in hepatocellular carcinoma treatment
Xuemei Zhang, Liming Zheng, Jia Shi, Shihan Yu, Wenlan Zheng, Hao Liu, Zhengzheng Wu, Hai Feng, Yueqiu Gao, Zhuo Yu · 2026 · Chinese Medicine
Preoperative albumin-bilirubin grade combined with sarcopenia predicts long-term outcomes after laparoscopic gastrectomy for advanced gastric cancer
2025
A Translational Model of MASLD-Associated HFpEF Defines Mitochondrial Dysfunction and Cardiac Plasticity During Disease Progression and Regression
Souradipta Ganguly, Betul Beyza Gunes, Yusu Gu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
The gut microbiome–tumor microenvironment axis in immunotherapy response: Mechanistic insights and clinical implications
Atul Kumar Gupta · 2026 · International Journal of Molecular and Immuno Oncology
Signaling Pathway Remodeling and Molecular Regulation in the HCC TME: Dynamic Evolution and Clinical Therapeutic Advances
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The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism
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Imran Shair Mohammad, Anup Kumar Patel, Steven T Rosen, Marcin Kortylewski, Jonathan Kessler, Julie Ressler, Chandana G. Lall, Catalina Guerra, Jason Chiang, Franz Edward Boas · 2026 · Cancers
Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology
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Polysaccharides-gut microbiota interaction: mechanisms regulating the hepatocellular carcinoma immune microenvironment
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Yingting Zhang, 龙喜带, Yinkun Fu, Xinxin Tang, Hao Luo, Zhihui Zou, Wei He, Longchuan Han, Yue Li, Jing Luo et al. · 2026 · Cell Metabolism
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CD47-SIRPα axis mediated by ncRNA correlates with poor prognosis, immune microenvironment dysregulation and lipid metabolism modulation in hepatocellular carcinoma
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