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Cited by 651T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

Location, location, location: Tissue resident memory T cells in mice and humans

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Szabo, Peter A., Miron, Michelle, Farber, Donna L.·2019·Science Immunology
DOI 10.1126/sciimmunol.aas9673PMC PMC6778482
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Abstract

This review summarizes key studies that have shaped our understanding of tissue resident memory T cells in mice and humans.

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Crossref · 10.1126/sciimmunol.aas9673

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  • The long local retention time likely allows for clonal selection of the best-adapted cells to the liver environment, promoting the tolerogenic role of these cells at the steady state.

    “The long local retention time likely allows for clonal selection of the best-adapted cells to the liver environment, promoting the tolerogenic role of these cells at the steady state(111, 112).”

    From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [111]

    The sections “Defining tissue residency for T cells” and “Distinguishing features of TRM” (pages not provided) describe long-term tissue retention and the establishment of liver-resident memory T cells. They do not say that retention selects cells best adapted to the liver or promotes a tolerogenic role at steady state. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Liver TRMs are primed in situ, promoting the local maturation of this cell subset.

    “Liver TRMs instead are primed in situ, promoting the local maturation of this cell subset.”

    From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [111]

    The 'Distinguishing features of TRM' section (page unavailable) says CXCR6 promotes liver CD8+ TRM establishment, and 'TRM as a target of vaccination' describes an approach targeting TRM formation in the liver. Neither passage says liver TRMs are primed in situ or that such priming promotes their local maturation. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

  • TRM cells can be distinguished from effector memory T cells by downregulation of S1PR1 and upregulation of tissue retention molecules like CD103 and CD69.

    “T RM cells can be distinguished from effector memory T cells by their downregulation of tissue egress protein S1PR1 (sphingosine 1-phosphate receptor) and upregulation of tissue retention molecules like CD103 and CD69. 292-294”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [292]

    The Introduction and “Distinguishing features of TRM” support reduced S1PR1 expression and CD69-mediated tissue retention as features distinguishing TRM from circulating memory T cells. They qualify CD103, however: it marks subsets of TRM in certain tissues, not TRM generally. The claim omits that limitation. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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References 125 · Cited by 651

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Authors
Szabo, P. A., Miron, M., & Farber, D. L.
Affiliations
  • Columbia University (US)
  • Columbia Center for Translational Immunology, Columbia University, New York, NY, USA.
ORCID
Venue
Science Immunology
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-04-12
Volume
4
Issue
34
ISSN
2470-9468 (ISSN-L)
DOI
10.1126/sciimmunol.aas9673
PMC
PMC6778482
OpenAlex
W2928871599
Cited by
651
References
125
Citations by year
2026: 61 · 2025: 118 · 2024: 108 · 2023: 88 · 2022: 91 · 2021: 101 · 2020: 68 · 2019: 15 · 2018: 1
FWCI
5.95
Type
journal article
Language
en
Open access
Locations
  • Science Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI106697, AI128949)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
tissue-resident memory T cells, memory T cells, T cell localization, mucosal immunity, immunological memory, mouse model, human T cells
MeSH terms
Animals, Disease Models, Animal, Humans, Immunologic Memory, Infections, T-Lymphocytes, Mice

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