A distinct GM-CSF + T helper cell subset requires T-bet to adopt a T H 1 phenotype and promote neuroinflammation
Abstract
A GM-CSF + T helper cell subset develops from naïve precursors and switch to a T H 1 phenotype during neuroinflammation.
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Th1 cells also regulate B cells and humoral immunity.
“Th1 cells are well-known to also regulate B cells and humoral immunity”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [24]
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References 46 · Cited by 57
- Authors
- Rasouli, J., Casella, G., Yoshimura, S., Zhang, W., Xiao, D., Garifallou, J., Gonzalez, M. V., Wiedeman, A., Kus, A., Mari, E. R., Fortina, P., Hakonarson, H., Long, S. A., Zhang, G.-X., Ciric, B., & Rostami, A.
- Affiliations
- Thomas Jefferson University (US)
- Children's Hospital of Philadelphia (US)
- Benaroya Research Institute (US)
- Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
- Corresponding author
- Rostami, Abdolmohamad
- ORCID
- Venue
- Science Immunology
- Published
- 2020-10-08
- Volume
- 5
- Issue
- 52
- ISSN
- 2470-9468 (ISSN-L)
- OpenAlex
- W3094514117
- Cited by
- 57
- References
- 46
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 9 · 2021: 7
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- GM-CSF, T helper cells, T-bet, Th1 phenotype, neuroinflammation, T cell differentiation, naive T cells, Th17 cells
- MeSH terms
- RNA-Seq, T-bet Transcription Factor, Animals, Encephalomyelitis, Autoimmune, Experimental, Female, Gene Expression Regulation, Humans, Male, Mice, Transgenic, Multiple Sclerosis, Granulocyte-Macrophage Colony-Stimulating Factor, Th1 Cells, Cell Lineage, T-Box Domain Proteins, Mice, Single-Cell Analysis, Healthy Volunteers
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