SARS-CoV-2 seroprevalence among parturient women in Philadelphia
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Abstract
More than 6% of parturient women in Philadelphia (4 April to 3 June 2020) had serological evidence of exposure to SARS-CoV-2.
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Several countries have monitored seroprevalence in blood transfusion donors or expectant mothers attending antenatal clinics.
“Several countries have monitored seroprevalence in blood transfusion donors (12, 13) or expectant mothers attending antenatal clinics (14).”
From Seroprevalence of anti–SARS-CoV-2 IgG antibodies in Kenyan blood donors (2021) · cites this paper as [14]
The estimated sensitivity of the SARS-CoV-2-specific antibody ELISA is 100% (95% CI, 89.1 to 100.0%).
“The estimated sensitivity of the test is 100% [95% confidence interval (CI), 89.1 to 100.0%], and the specificity is 98.9% (95% CI, 98.0 to 99.5%) (45).”
From Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination (2021) · cites this paper as [45]
The estimated specificity of the SARS-CoV-2-specific antibody ELISA is 98.9% (95% CI, 98.0 to 99.5%).
“The estimated sensitivity of the test is 100% [95% confidence interval (CI), 89.1 to 100.0%], and the specificity is 98.9% (95% CI, 98.0 to 99.5%) (45).”
From Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination (2021) · cites this paper as [45]
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References 27 · Cited by 125
Research works printed but not linked: 3
- [4]J. D. Whitman, J. Hiatt, C. T. Mowery, B. R. Shy, R. Yu, T. N. Yamamoto, U. Rathore, G. M. Goldgof, C. Whitty, J. M. Woo, A. E. Gallman, T. E. Miller, A. G. Levine, D. N. Nguyen, S. P. Bapat, J. Balcerek, S. Bylsma, A. M. Lyons, S. Li, A. W. Wong, E. M. Gillis-Buck, Z. B. Steinhart, Y. Lee, R. Apathy, M. J. Lipke, J. A. Smith, T. Zheng, I. C. Boothby, E. Isaza, J. Chan, D. D. Acenas, J. Lee, T. A. Macrae, T. S. Kyaw, D. Wu, D. L. Ng, W. Gu, V. A. York, H. A. Eskandarian, P. C. Callaway, L. Warrier, M. E. Moreno, J. Levan, L. Torres, L. Farrington, R. Loudermilk, K. Koshal, K. C. Zorn, W. F. Garcia-Beltran, D. Yang, M. G. Astudillo, B. E. Bernstein, J. A. Gelfand, E. T. Ryan, R. C. Charles, A. J. Iafrate, J. K. Lennerz, S. Miller, C. Y. Chiu, S. L. Stramer, M. R. Wilson, A. Manglik, C. J. Ye, N. J. Krogan, M. S. Anderson, J. G. Cyster, J. D. Ernst, A. H. B. Wu, K. L. Lynch, C. Bern, P. D. Hsu, A. Marson, Test performance evaluation of SARS-CoV-2 serological assays, medRxiv, 2020.04.25.20074856 (2020).
- [6]F. Amanat, T. Nguyen, V. Chromikova, S. Strohmeier, D. Stadlbauer, A. Javier, K. Jiang, G. Asthagiri-Arunkumar, J. Polanco, M. Bermudez-Gonzalez, D. Caplivski, A. Cheng, K. Kedzierska, O. Vapalahti, J. Hepojoki, V. Simon, F. Krammer, A serological assay to detect SARS-CoV-2 seroconversion in humans, medRxiv, 2020.03.17.20037713 (2020).
- [18]W. Liu, Q. Wang, Q. Zhang, L. Chen, J. Chen, B. M. Zhang, S. Wang, L. Xia, L. Huang, K. B. Wang, L. B. Liang, Y. M. Zhang, L. Turtle, D. Lissauer, K. Lan, L. Feng, Y. Liu, Z. Sun, Title: Coronavirus disease 2019 (COVID-19) during pregnancy: a case series (Preprints, 2020; www.preprints.org).
- Authors
- Flannery, D. D., Gouma, S., Dhudasia, M. B., Mukhopadhyay, S., Pfeifer, M. R., Woodford, E. C., Gerber, J. S., Arevalo, C. P., Bolton, M. J., Weirick, M. E., Goodwin, E. C., Anderson, E. M., Greenplate, A. R., Kim, J., Han, N., Pattekar, A., Dougherty, J., Kuthuru, O., Mathew, D., Baxter, A. E., Vella, L. A., Weaver, J., Verma, A., Leite, R., Morris, J. S., Rader, D. J., Elovitz, M. A., Wherry, E. J., Puopolo, K. M., & Hensley, S. E.
- Affiliations
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
- Corresponding author
- Puopolo, Karen M.
- Hensley, Scott E.
- ORCID
- Flannery, Dustin D.
- Gouma, Sigrid
- Dhudasia, Miren B.
- Mukhopadhyay, Sagori
- Woodford, Emily C.
- Gerber, Jeffrey S.
- Arevalo, Claudia P.
- Bolton, Marcus J.
- Weirick, Madison E.
- Anderson, Elizabeth M.
- Greenplate, Allison R.
- Kim, Justin
- Han, Nicholas
- Pattekar, Ajinkya
- Dougherty, Jeanette
- Kuthuru, Oliva
- Mathew, Divij
- Baxter, Amy E.
- Vella, Laura A.
- Weaver, JoEllen
- Verma, Anurag
- Leite, Rita
- Morris, Jeffrey S.
- Rader, Daniel J.
- Elovitz, Michal A.
- Wherry, E. John
- Puopolo, Karen M.
- Hensley, Scott E.
- Venue
- Science Immunology
- Published
- 2020-07-03
- Volume
- 5
- Issue
- 49
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC7594018
- OpenAlex
- W3045609246
- Cited by
- 125
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 12 · 2023: 14 · 2022: 18 · 2021: 48 · 2020: 29
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Science Immunology (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (AI082630)
- National Center for Advancing Translational Sciences of the National Institutes of Health (UL1TR001878)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- SARS-CoV-2, COVID-19 pandemic, seroprevalence, pregnant women, parturients, spike protein receptor-binding domain, IgM and IgG antibodies, racial and ethnic disparities, perinatal exposure, Philadelphia
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