The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pharmacological PKA Inhibition: All May Not Be What It Seems
Abstract
Signaling through the cyclic adenosine monophosphate–dependent protein kinase [protein kinase A (PKA)] is an important and widely studied area of signal transduction research. This signaling pathway is commonly investigated through the use of the pharmacological PKA inhibitors H89 and KT 5720. Both of these compounds are thought to block PKA actions through competitive inhibition of the adenosine triphosphate site on the PKA catalytic subunit. Recently, a number of studies have identified actions of H89 and KT 5720 that are independent of their effects on PKA. These nonspecific effects are widespread; they include actions on other protein kinases and signaling molecules and also on basic cellular functions, such as transcription. Here, I summarize the nonspecific effects of these two compounds and compare their actions with those of other PKA inhibitors.
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Cited by
Yao, C., Sakata, D., Esaki, Y., Li, Y., Matsuoka, T., Kuroiwa, K., Sugimoto, Y., & Narumiya, S. (2009) · Nature Medicine · doi:10.1038/nm.1968 · Cited by 566
Atropisomerism in Medicinal Chemistry: Challenges and Opportunities
Toenjes, S. T., & Gustafson, J. L. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0152 · Cited by 382
Cytochrome c oxidase dysfunction in oxidative stress
Srinivasan, S., & Avadhani, N. G. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.021 · Cited by 373
Recurrent somatic mutations underlie corticotropin-independent Cushing’s syndrome
Sato, Y., Maekawa, S., Ishii, R., Sanada, M., Morikawa, T., Shiraishi, Y., Yoshida, K., Nagata, Y., Sato-Otsubo, A., Yoshizato, T., et al. (2014) · Science · doi:10.1126/science.1252328 · Cited by 209
cAMP-Dependent Axon Guidance Is Distinctly Regulated by Epac and Protein Kinase A
Murray, A. J., Tucker, S. J., & Shewan, D. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3071-09.2009 · Cited by 80
Self-citation
Metadata
- Authors
- Murray, A. J.
- Venue
- Science Signaling
- Published
- 2008-06-03
- Volume
- 1
- Issue
- 22
- Pages
- re4-re4
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2155056221
- Cited by
- 327
- References
- 5
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- closed
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