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Cited by 130Nerve injury and regenerationAlzheimer's disease research and treatmentsCellular transport and secretion

Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.

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Shi, Yang, Mantuano, Elisabetta, Inoue, Gen, Campana, W. Marie, Gonias, Steven L.·2009·Science Signaling
DOI 10.1126/scisignal.2000188PMC PMC2696635
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Abstract

Trk receptor–mediated neurite outgrowth is triggered by distinct ligands that activate LRP1.

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Crossref · 10.1126/scisignal.2000188

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  • Phosphorylation of Trk receptors was necessary for neurite outgrowth.

    “Phosphorylation of Trk receptors was necessary for neurite outgrowth.”

    From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Shi et al., 2009

    The Results ('Trk receptors are activated downstream of LRP1 in CGNs') report that a Trk receptor inhibitor blocked α2M RBD-induced neurite outgrowth, supporting a requirement for Trk activation in that response. The claim omits the limiting condition: the paper establishes this requirement for neurite outgrowth downstream of LRP1, not neurite outgrowth generally. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Activation of LRP1 by other ligands, such as tissue-type plasminogen activator (tPA) or α2-macroglobulin, activates Src family kinase and TrK receptor in neurons.

    “Shi et al. (2009) demonstrated that activation of LRP1 by other ligands, such as tissue-type plasminogen activator (tPA) or α2-macroglobulin, activates Src family kinase and TrK receptor in neurons (Fig. 1B).”

    From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Shi et al., 2009

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Research works printed but not linked: 43

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Sorted by citations

Authors
Shi, Y., Mantuano, E., Inoue, G., Campana, W. M., & Gonias, S. L.
Affiliations
  • University of California San Diego (US)
  • Chiba University (JP)
Corresponding author
Gonias, Steven L.
ORCID
Venue
Science Signaling
Publisher
American Association for the Advancement of Science (AAAS)
Published
2009-04-28
Volume
2
Issue
68
Pages
ra18-ra18
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
DOI
10.1126/scisignal.2000188
PMC
PMC2696635
OpenAlex
W2060036340
Cited by
130
References
2
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 6 · 2016: 14 · 2015: 14 · 2014: 12 · 2013: 13 · 2012: 9
FWCI
4.16
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS054671)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
LRP1, Trk receptors, receptor transactivation, Src family kinases, tissue plasminogen activator, alpha2-macroglobulin, Akt signaling, ERK signaling, neurite outgrowth, neurotrophic activity, receptor-associated protein, dorsal root ganglia, neuronal signaling
MeSH terms
alpha-Macroglobulins, Animals, Animals, Newborn, Carbazoles, Cells, Cultured, Enzyme Activation, Ligands, Models, Biological, Neurons, Protein Binding, Transfection, Immunoblotting, Signal Transduction, Neurites, PC12 Cells, Rats, Sprague-Dawley, src-Family Kinases, Receptor, trkA, Indole Alkaloids, Low Density Lipoprotein Receptor-Related Protein-1, RNA, Small Interfering, Extracellular Signal-Regulated MAP Kinases, Proto-Oncogene Proteins c-akt, Rats

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