Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation
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Localized production of reactive oxygen species is key for cellular invasiveness and may be involved in a positive feedback loop with proteins that organize their site of production.
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Tks4/5, a homolog of NOXO1, regulates NOX4 activity.
“The membrane protein Toll-like receptor 4 (TLR4) has been shown to increase NOX4 activity (86, 724), and Tks4/5, a homolog of NOXO1, also regulates NOX4 activity (231).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [231]
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References 81 · Cited by 242
- Authors
- Diaz, B., Shani, G., Pass, I., Anderson, D., Quintavalle, M., & Courtneidge, S. A.
- Affiliations
- Tumor Microenvironment Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Shani, Gidon
- Courtneidge, Sara A.
- ORCID
- Courtneidge, Sara A.
- Venue
- Science Signaling
- Published
- 2009-09-15
- Volume
- 2
- Issue
- 88
- Pages
- ra53-ra53
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC2810640
- OpenAlex
- W2104105936
- Cited by
- 242
- References
- 81
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 15 · 2019: 15 · 2018: 20 · 2017: 21 · 2016: 10 · 2015: 13 · 2014: 20 · 2013: 30 · 2012: 21
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA098383, R01CA129686)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- invadopodia, reactive oxygen species, NADPH oxidase, Tks5, Tks4, p22phox, p47phox, tyrosine phosphorylation, positive feedback loop, tumor invasion, pericellular proteolysis, Src homology 3 domain
- MeSH terms
- Animals, Cell Line, Cytochrome b Group, Humans, Phosphoproteins, Phosphorylation, Transfection, Reactive Oxygen Species, NADPH Oxidases, Cell Surface Extensions, Feedback, Physiological, Phosphate-Binding Proteins, Adaptor Proteins, Vesicular Transport, RNA, Small Interfering, Cell Line, Tumor, Mice
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