Three-dimensional docking in the MAPK p38α
Abstract
Structural analysis reveals the mode of interaction between a mitogen-activated protein kinase and its inactivating phosphatase.
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Allostery among the catalytic site, activation loop, and peptide-docking site is well documented for ERK and p38 MAPKs but is less understood for JNK.
“Allostery among the catalytic site, A-loop, and peptide-docking site of ERK and p38 MAPKs has been well documented (Chang et al., 2002; Goldsmith, 2011; Lee et al., 2004; Wang et al., 1997; Zhang et al., 1994; Zhou et al., 2006a, 2006b), but much less is known about these processes for JNK.”
From Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases (2012) · cites this paper as Goldsmith, 2011
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References 23 · Cited by 8
- Authors
- Goldsmith, E. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Goldsmith, Elizabeth J.
- Venue
- Science Signaling
- Published
- 2011-12-20
- Volume
- 4
- Issue
- 204
- Pages
- pe47-pe47
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2112996397
- Cited by
- 8
- References
- 23
- Citations by year
- 2019: 2 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- mitogen-activated protein kinase, MAPK phosphatase, protein-protein docking, protein structure, MAPK signaling
- MeSH terms
- Animals, Humans, Models, Molecular, Protein Structure, Tertiary, Amino Acid Motifs, MAP Kinase Signaling System, Mitogen-Activated Protein Kinase 14, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases
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