Pseudogenes: newly discovered players in human cancer.
Abstract
Because they are generally noncoding and thus considered nonfunctional and unimportant, pseudogenes have long been neglected. Recent advances have established that the DNA of a pseudogene, the RNA transcribed from a pseudogene, or the protein translated from a pseudogene can have multiple, diverse functions and that these functions can affect not only their parental genes but also unrelated genes. Therefore, pseudogenes have emerged as a previously unappreciated class of sophisticated modulators of gene expression, with a multifaceted involvement in the pathogenesis of human cancer.
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Recent evidence suggests that some pseudogenes are actively transcribed and play critical roles in gene regulation.
“recent evidence suggests that some are actively transcribed and play critical roles in gene regulation (Zheng and Gerstein 2007; Muro et al. 2011; Poliseno 2012).”
From RNA-Seq Alignment to Individualized Genomes Improves Transcript Abundance Estimates in Multiparent Populations (2014) · cites this paper as Poliseno 2012
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References 177 · Cited by 170
- Authors
- Poliseno, L.
- Affiliations
- Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori (CRL-ITT), c/o IFC-CNR Via Moruzzi 1, 56124 Pisa, Italy.
- Corresponding author
- Poliseno, Laura
- ORCID
- Poliseno, Laura
- Venue
- Science Signaling
- Published
- 2012-09-18
- Volume
- 5
- Issue
- 242
- Pages
- re5-re5
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2000059965
- Cited by
- 170
- References
- 177
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 8 · 2022: 8 · 2021: 31 · 2020: 12 · 2019: 12 · 2018: 14 · 2017: 12 · 2016: 8 · 2015: 12 · 2014: 22 · 2013: 9 · 2012: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- pseudogenes, human cancer, carcinogenesis, gene expression regulation, non-coding RNA
- MeSH terms
- DNA, Neoplasm, Humans, Neoplasm Proteins, Neoplasms, Pseudogenes, RNA, Neoplasm, Transcription, Genetic, Protein Biosynthesis, Genes, Neoplasm
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