Conserved regulators of nucleolar size revealed by global phenotypic analyses
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Loss-of-function analyses in yeast and flies identify molecular complexes that regulate ribosomal DNA transcription.
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Loss of a ribosome assembly factor Nopp140 leads to both reduced rRNA synthesis and R2 activation.
“Our assumptions are consistent with previous finding that loss of a ribosome assembly factor Nopp140 leads to both reduced rRNA synthesis (101) and R2 activation (64).”
From Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon (2022) · cites this paper as [101]
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References 82 · Cited by 87
- Authors
- Neumüller, R. A., Gross, T., Samsonova, A. A., Vinayagam, A., Buckner, M., Founk, K., Hu, Y., Sharifpoor, S., Rosebrock, A. P., Andrews, B., Winston, F., & Perrimon, N.
- Affiliations
- Harvard University (US)
- University of Toronto (CA)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Neumüller, Ralph A.
- Gross, Thomas
- Winston, Fred
- Perrimon, Norbert
- ORCID
- Venue
- Science Signaling
- Published
- 2013-08-20
- Volume
- 6
- Issue
- 289
- Pages
- ra70-ra70
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3964804
- OpenAlex
- W2149150109
- Cited by
- 87
- References
- 82
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 12 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 1
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Canadian Institutes of Health Research (MOP97939, MOP-275194)
- National Cancer Institute (P01CA120964)
- National Institute of General Medical Sciences (R01GM045720, R01GM067761)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK088718)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR057352)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- nucleolar size, RNA polymerase I, rRNA transcription, cell growth regulation, Saccharomyces cerevisiae, Drosophila melanogaster, cancer cell growth
- MeSH terms
- Cell Nucleolus, DNA, Fungal, DNA, Ribosomal, Genes, Fungal, Histones, RNA Polymerase I, RNA, Fungal, RNA, Ribosomal, Saccharomyces cerevisiae, Transcription, Genetic, Genes, rRNA, Saccharomyces cerevisiae Proteins
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