The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells
Abstract
By binding to Notch target genes, Ikaros shuts off the expression of these genes in T cells and prevents the development of T cell acute lymphoblastic leukemia.
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Notch activated target genes like Hes1 are expressed throughout pro-T cell phases (ETP to DN3) until TCR gene rearrangement.
“Notch activated target genes like Hes1 are expressed throughout the pro-T cell phases (ETP to DN3), until T-cell receptor (TCR) gene rearrangement (62–64)”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [64]
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding
Cobb, B. S., Morales-Alcelay, S., Kleiger, G., Brown, K. E., Fisher, A. G., & Smale, S. T. (2000) · Genes & Development · doi:10.1101/gad.816400 · Cited by 252 · see citing works
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Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99 · see citing works
- Authors
- Geimer Le Lay, A.-S., Oravecz, A., Mastio, J., Jung, C., Marchal, P., Ebel, C., Dembélé, D., Jost, B., Le Gras, S., Thibault, C., Borggrefe, T., Kastner, P., & Chan, S.
- Affiliations
- Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR 7104, Université de Strasbourg, 67404 Illkirch, France.
- Centre National de la Recherche Scientifique (FR)
- University of Freiburg (DE)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- IGBMC Microarray and Sequencing Platform, IGBMC, 67404 Illkirch, France.
- Justus-Liebig-Universität Gießen (DE)
- Corresponding author
- Kastner, Philippe
- Chan, Susan
- ORCID
- Venue
- Science Signaling
- Published
- 2014-03-18
- Volume
- 7
- Issue
- 317
- Pages
- ra28-ra28
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2039739637
- Cited by
- 74
- References
- 2
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 13 · 2015: 13 · 2014: 4
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-BSV3-0018)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- Ikaros, Notch signaling, Notch target genes, T cell development, thymocytes, transcriptional repression, T-cell leukemia, ChIP-seq, transcription factor binding, tissue-specific gene regulation, tumor suppression
- MeSH terms
- Chromatin, Gene Expression Regulation, Humans, Protein Binding, Regulatory Sequences, Nucleic Acid, T-Lymphocytes, Transcription, Genetic, Genes, Tumor Suppressor, Ikaros Transcription Factor, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Receptors, Notch, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
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