Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis
Abstract
DNA damage not only promotes a mitotic checkpoint response but also activates a pathway that can produce fibrotic disease.
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ROS, via oxidation of thioredoxin, enhance the nuclear localization of ATM and Ref-1.
“ROS, via oxidation of thioredoxin, enhance the nuclear localization of both the ataxia-telangiectasia mutated (ATM) serine/threonine kinase, which is involved in DNA damage repair31,32, and redox factor-1 (Ref-1), a multifunctional protein that enables Fos/Jun DNA-binding and is identical to the apurinic/apyrimidinic 1 (APE1) endonuclease33.”
From ROS in cancer therapy: the bright side of the moon (2020) · cites this paper as [32]
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References 59 · Cited by 100
- Authors
- Svegliati, S., Marrone, G., Pezone, A., Spadoni, T., Grieco, A., Moroncini, G., Grieco, D., Vinciguerra, M., Agnese, S., Jüngel, A., Distler, O., Musti, A. M., Gabrielli, A., & Avvedimento, E. V.
- Affiliations
- Marche Polytechnic University (IT)
- University of Naples Federico II (IT)
- Cancer Research UK (GB)
- University Hospital Zurich (CH)
- University of Calabria (IT)
- Corresponding author
- Svegliati, Silvia
- Marrone, Giusi
- Pezone, Antonio
- Gabrielli, Armando
- Avvedimento, Enrico V.
- ORCID
- Venue
- Science Signaling
- Published
- 2014-09-02
- Volume
- 7
- Issue
- 341
- Pages
- ra84-ra84
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2124832584
- Cited by
- 100
- References
- 59
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 8 · 2021: 8 · 2020: 21 · 2019: 7 · 2018: 10 · 2017: 9 · 2016: 10 · 2015: 2 · 2014: 1
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
- Keywords
- systemic sclerosis, WIF1, Wnt signaling, oxidative DNA damage, ATM kinase, c-Jun, ATF3, HDAC3, β-catenin, collagen synthesis, fibrosis, autoantibodies, reactive oxygen species, histone deacetylase, trichostatin A, fibroblasts
- MeSH terms
- Collagen Type I, alpha 1 Chain, Antibiotics, Antineoplastic, Biopsy, Bleomycin, DNA Damage, Fibroblasts, Fibrosis, Humans, Hydroxamic Acids, Immunoglobulin G, Oxygen, Protein Synthesis Inhibitors, Repressor Proteins, Scleroderma, Systemic, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, DNA Methylation, Gene Silencing, Collagen Type I, Adaptor Proteins, Signal Transducing, Wnt Proteins, Ataxia Telangiectasia Mutated Proteins
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