Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling
Abstract
A signaling pathway that promotes the cytoskeleton remodeling in osteoclasts necessary for bone resorption is elucidated.
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WNT5a produced by osteoblasts supports osteoclastogenesis by stimulating RANK expression in osteoclast precursors, promoting osteoclast fusion, and supporting actin ring formation and bone resorption via c-Src.
“WNT5a produced by osteoblasts supports osteoclastogenesis by stimulating RANK expression in osteoclast precursors,180 promoting osteoclast fusion,181 and supporting actin ring formation and bone resorption via c-Src.182”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [182]
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References 57 · Cited by 83
- Authors
- Uehara, S., Udagawa, N., Mukai, H., Ishihara, A., Maeda, K., Yamashita, T., Murakami, K., Nishita, M., Nakamura, T., Kato, S., Minami, Y., Takahashi, N., & Kobayashi, Y.
- Affiliations
- Matsumoto Dental University (JP)
- Biosignal Research Center, Kobe University (JP)
- Tokyo Medical and Dental University (JP)
- Jikei University School of Medicine (JP)
- Kobe University (JP)
- Tokyo Dental College (JP)
- IRYO Sosei University (JP)
- Corresponding author
- Kobayashi, Yasuhiro
- ORCID
- Venue
- Science Signaling
- Published
- 2017-08-29
- Volume
- 10
- Issue
- 494
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2750887532
- Cited by
- 83
- References
- 57
- Citations by year
- 2026: 10 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 8
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (17K07168, 16H05152, 16H02691, 17K16686, 15K11059, 17K08634, 16H05508, 16H05144)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- bone resorption, osteoclasts, Wnt5a, ROR2, Rho GTPase signaling, osteoporosis, rheumatoid arthritis, periodontal disease
- MeSH terms
- Wnt-5a Protein, CSK Tyrosine-Protein Kinase, Actins, Animals, Arthritis, Rheumatoid, Bone Resorption, Disease Models, Animal, Humans, Mice, Transgenic, Microfilament Proteins, Osteoclasts, Osteoporosis, Periodontal Diseases, Phosphorylation, Protein Kinase C, src-Family Kinases, rho GTP-Binding Proteins, rhoA GTP-Binding Protein, Mice, Focal Adhesion Kinase 2, Receptor Tyrosine Kinase-like Orphan Receptors
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