The DOI matches its Crossref record.
Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses
Abstract
Autocrine responses to interleukin-6 family cytokines are insensitive to extracellular gp130 signaling receptor blockade.
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“Although sgp130 does not inhibit classic signaling, it binds to the IL-6-mIL-6R complex, thereby blocking IL-6 trans-presentation (Lamertz et al., 2018”
From Targeting Interleukin-6 Signaling in Clinic (2019) · cites this paper as Lamertz et al., 2018
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Cited by
Sorted by citations
Targeting Interleukin-6 Signaling in Clinic
Kang, S., Tanaka, T., Narazaki, M., & Kishimoto, T. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.026 · Cited by 904
Pleiotropy and specificity: insights from the interleukin 6 family of cytokines
Murakami, M., Kamimura, D., & Hirano, T. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.027 · Cited by 533
Targeting IL-6 trans-signalling: past, present and future prospects
Rose-John, S., Jenkins, B. J., Garbers, C., Moll, J. M., & Scheller, J. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00856-y · Cited by 524
Self-citationNew insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S., & Bustos, M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00473-x · Cited by 156
IL-6 Revisited: From Rheumatoid Arthritis to CAR T Cell Therapy and COVID-19
Kishimoto, T., & Kang, S. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101220-023458 · Cited by 140
Metadata
- Authors
- Lamertz, L., Rummel, F., Polz, R., Baran, P., Hansen, S., Waetzig, G. H., Moll, J. M., Floss, D. M., & Scheller, J.
- Affiliations
- Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.
- CONARIS Research Institute AG, Kiel 24118, Germany.
- Venue
- Science Signaling
- Published
- 2018-10-02
- Volume
- 11
- Issue
- 550
- ISSN
- 1945-0877
- 1937-9145
- Cited by
- 70
- References
- 0
- Language
- en
- Funders
- Bundesministerium für Bildung und Forschung (InTraSig)
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- CoChat. (2026). Citation check: Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses. https://app.cochat.ai/papers/10.1126/scisignal.aar7388
- The paper
- Lamertz, L., Rummel, F., Polz, R., Baran, P., Hansen, S., Waetzig, G. H., Moll, J. M., Floss, D. M., & Scheller, J. (2018). Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses. Science Signaling. https://doi.org/10.1126/scisignal.aar7388