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Cited by 171Inflammasome and immune disordersImmune Response and InflammationHeavy Metal Exposure and Toxicity

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.

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Sarkar, Souvarish, Rokad, Dharmin, Malovic, Emir, Luo, Jie, Harischandra, Dilshan S., Jin, Huajun, Anantharam, Vellareddy, Huang, Xuemei +3 more·2019·Science Signaling
DOI 10.1126/scisignal.aat9900PMC PMC6420319
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Abstract

Exosomes containing the adaptor ASC spread NLRP3 inflammasome activation between cells after manganese exposure.

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  • Genetic factors may contribute only between 50 and 70% of the risk for LOAD.

    “Studies also suggest that genetic factors may only contribute between 50 and 70% of the risk for LOAD, meaning many individuals are likely to develop LOAD due to a combination of genetic and environmental factors (Kawahara et al., 2017; Sarkar et al., 2019; Rahman et al., 2020; Kim et al., 2021).”

    From Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice (2022) · cites this paper as Sarkar et al., 2019

    The Introduction (page not provided) says that the etiology of Alzheimer’s disease is multifactorial, which supports the broad point that factors beyond genetics may be involved. It does not give a 50–70% estimate for genetic risk or specifically address late-onset Alzheimer’s disease (LOAD); searches for those terms found no supporting passage. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Many individuals are likely to develop LOAD due to a combination of genetic and environmental factors.

    “Studies also suggest that genetic factors may only contribute between 50 and 70% of the risk for LOAD, meaning many individuals are likely to develop LOAD due to a combination of genetic and environmental factors (Kawahara et al., 2017; Sarkar et al., 2019; Rahman et al., 2020; Kim et al., 2021).”

    From Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice (2022) · cites this paper as Sarkar et al., 2019

    The Introduction (page unavailable) says that Alzheimer’s disease has a multifactorial etiology and links environmental metal exposure to AD. It does not specifically address late-onset Alzheimer’s disease (LOAD), establish a combined genetic-and-environmental risk for individuals, or give the cited 50–70% genetic-risk estimate. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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References 104 · Cited by 171

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Authors
Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A., & Kanthasamy, A. G.
Affiliations
  • Iowa State University (US)
  • Pennsylvania State University (US)
Corresponding author
  • Sarkar, Souvarish
  • Kanthasamy, Anumantha G.
ORCID
Venue
Science Signaling
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-01-08
Volume
12
Issue
563
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
DOI
10.1126/scisignal.aat9900
PMC
PMC6420319
OpenAlex
W2909458901
Cited by
171
References
104
Citations by year
2026: 18 · 2025: 29 · 2024: 19 · 2023: 27 · 2022: 26 · 2021: 26 · 2020: 16 · 2019: 9
FWCI
6.37
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (ES026892, NS088206)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
manganese, NLRP3 inflammasome, ASC, exosomes, microglia, mitochondrial dysfunction, IL-1β, welders, occupational manganese exposure, cell-to-cell transmission, neuroinflammation
MeSH terms
NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Cells, Cultured, Male, Manganese, Mice, Inbred C57BL, Welding, Signal Transduction, Microglia, Caspase 1, CARD Signaling Adaptor Proteins, Interleukin-1beta, Exosomes, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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