KRAS G12C inhibition produces a driver-limited state revealing collateral dependencies

Lou, Kevin, Steri, Veronica, Ge, Alex Y., Hwang, Y. Christina, Yogodzinski, Christopher H., Shkedi, Arielle R., Choi, Alex L. M., Mitchell, Dominique C. +5 more·2019·Science Signaling

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  16. The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations
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  17. Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies
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