A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo
Abstract
A human antibody inhibits BACE1 activity and Aβ peptide production in cultured neurons and in the central nervous system of mouse and monkey.
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Anti-TfR-BACE1 antibody has shown promise in Alzheimer's Tg2576 mice and nonhuman primates.
“including anti-TfR-BACE1 antibody in Alzheimer's Tg2576 mice (34) and nonhuman primates (672)”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [34]
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References 33 · Cited by 274
- Authors
- Atwal, J. K., Chen, Y., Chiu, C., Mortensen, D. L., Meilandt, W. J., Liu, Y., Heise, C. E., Hoyte, K., Luk, W., Lu, Y., Peng, K., Wu, P., Rouge, L., Zhang, Y., Lazarus, R. A., Scearce-Levie, K., Wang, W., Wu, Y., Tessier-Lavigne, M., & Watts, R. J.
- Affiliations
- Genentech (US)
- Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA.
- Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
- Corresponding author
- Watts, Ryan J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2011-05-25
- Volume
- 3
- Issue
- 84
- Pages
- 84ra43-84ra43
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2026422955
- Cited by
- 274
- References
- 33
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 19 · 2022: 11 · 2021: 19 · 2020: 11 · 2019: 20 · 2018: 16 · 2017: 21 · 2016: 22 · 2015: 16 · 2014: 25 · 2013: 33 · 2012: 26
- FWCI
- 21.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- BACE1, amyloid-beta, Alzheimer's disease, therapeutic antibodies, passive immunization, APP processing, blood-brain barrier penetration, non-human primates
- MeSH terms
- Amino Acid Sequence, Animals, Antibodies, Biological Assay, Brain, Endocytosis, Humans, Macaca fascicularis, Models, Molecular, Molecular Sequence Data, Neurons, Protein Binding, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Treatment Outcome, Crystallography, X-Ray, Peptide Library, Mice, Amyloid Precursor Protein Secretases
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