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Cited by 76Viral Infections and Immunology ResearchCardiac Fibrosis and RemodelingDiabetes and associated disorders

Myocardial Infarction Triggers Chronic Cardiac Autoimmunity in Type 1 Diabetes

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Gottumukkala, Raju V. S. R. K., Lv, HuiJuan, Cornivelli, Lizbeth, Wagers, Amy J., Kwong, Raymond Y., Bronson, Roderick, Stewart, Garrick C., Schulze, P. Christian +4 more·2012·Science Translational Medicine
DOI 10.1126/scitranslmed.3003551PMC PMC4303259
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Abstract

Acute myocardial infarction triggers an autoimmune attack on the heart in a mouse model of type 1 diabetes and in human type 1 diabetic patients.

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Crossref · 10.1126/scitranslmed.3003551

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  • A recent report found that after myocardial infarction, patients with type 1 diabetes express antibodies to cardiac proteins, whereas patients with type 2 diabetes do not.

    “a finding that might be explained by a recent report that, after myocardial infarction, patients with type 1 diabetes express antibodies to cardiac proteins, whereas patients with type 2 diabetes do not.111”

    From Type 1 diabetes (2014) · cites this paper as [111]

    The Results section ('Discovery of a PIA syndrome in human T1D patients'; page not provided) reports cardiac autoantibodies in 15/18 post-MI patients with type 1 diabetes, supporting that part of the claim. It also reports them in 3/20 post-MI patients with type 2 diabetes, so the assertion that those patients do not express such antibodies is too absolute. (LLM, conf=0.92)

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References 56 · Cited by 76

Research works printed but not linked: 35

  1. [1]Brown JR O'Connor GT Coronary heart disease and prevention in the United States N Engl J Med 2010 362 2150 20558365
  2. [2]Libby P Nathan DM Abraham K Brunzell JD Fradkin JE Haffner SM Hsueh W Rewers M Roberts BT Savage PJ Skarlatos S Wassef M Rabadan-Diehl C Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus Circulation 2005 111 3489 15983263
  3. [3]Secrest AM Becker DJ Kelsey SF Laporte RE Orchard TJ Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes Diabetes 2010 59 3216 20739685 PMC2992785
  4. [4]Pambianco G Costacou T Ellis D Becker DJ Klein R Orchard TJ The 30-year natural history of type 1 diabetes complications: the Pittsburgh Epidemiology of Diabetes Complications Study experience Diabetes 2006 55 1463 16644706
  5. [5]Krolewski AS Kosinski EJ Warram JH Leland OS Busick EJ Asmal AC Rand LI Christlieb AR Bradley RF Kahn CR Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus Am J Cardiol 1987 59 750 3825934
  6. [6]Nathan DM Cleary PA Backlund JY Genuth SM Lachin JM Orchard TJ Raskin P Zinman B Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes N Engl J Med 2005 353 2643 16371630 PMC2637991
  7. [8]Entman ML Michael L Rossen RD Dreyer WJ Anderson DC Taylor AA Smith CW Inflammation in the course of early myocardial ischemia FASEB J 1991 5 2529 1868978
  8. [9]Frangogiannis NG The immune system and cardiac repair Pharmacol Res 2008 58 88 18620057 PMC2642482
  9. [10]Nahrendorf M Pittet MJ Swirski FK Monocytes: protagonists of infarct inflammation and repair after myocardial infarction Circulation 2010 121 2437 20530020 PMC2892474
  10. [11]Zhang J Yu ZX Fujita S Yamaguchi ML Ferrans VJ Interstitial dendritic cells of the rat heart. Quantitative and ultrastructural changes in experimental myocardial infarction Circulation 1993 87 909 8443911
  11. [12]Gallucci S Lolkema M Matzinger P Natural adjuvants: endogenous activators of dendritic cells Nat Med 1999 5 1249 10545990
  12. [13]Kono H Rock KL How dying cells alert the immune system to danger Nat Rev Immunol 2008 8 279 18340345 PMC2763408
  13. [14]Chervonsky AV Influence of microbial environment on autoimmunity Nat Immunol 2010 11 28 20016507
  14. [15]Iwasaki A Medzhitov R Regulation of adaptive immunity by the innate immune system Science 2010 327 291 20075244 PMC3645875
  15. [17]Taylor JA Havari E McInerney MF Bronson R Wucherpfennig KW Lipes MA A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8 J Immunol 2004 172 2651 14764740
  16. [19]Dressler W A post-myocardial infarction syndrome; preliminary report of a complication resembling idiopathic, recurrent, benign pericarditis J Am Med Assoc 1956 160 1379 13306560
  17. [20]Moraru M Roth A Keren G George J Cellular autoimmunity to cardiac myosin in patients with a recent myocardial infarction International Journal of Cardiology 2006 107 61 16337499
  18. [21]Goser S Andrassy M Buss SJ Leuschner F Volz CH Ottl R Zittrich S Blaudeck N Hardt SE Pfitzer G Rose NR Katus HA Kaya Z Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium Circulation 2006 114 1693 17015788
  19. [22]Volz HC Buss SJ Li J Goser S Andrassy M Ottl R Pfitzer G Katus HA Kaya Z Autoimmunity against cardiac troponin I in ischaemia reperfusion injury European Journal of Heart Failure 2011 13 1052 21816762
  20. [23]Nussinovitch U Shoenfeld Y The Clinical and Diagnostic Significance of Anti-myosin Autoantibodies in Cardiac Disease Clinical Reviews in Allergy & Immunology 2011 21207194
  21. [24]Sherwood RI Christensen JL Conboy IM Conboy MJ Rando TA Weissman IL Wagers AJ Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle Cell 2004 119 543 15537543
  22. [25]Bingley PJ Williams AJ Validation of autoantibody assays in type 1 diabetes: workshop programme Autoimmunity 2004 37 257 15518037
  23. [26]Stewart GC Lopez-Molina J Gottumukkala RV Rosner GF Anello MS Hecht JL Winters GL Padera RF Baughman KL Lipes MA Myocardial parvovirus B19 persistence: lack of association with clinicopathologic phenotype in adults with heart failure Circ Heart Fail 2011 4 71 21097605 PMC3047418
  24. [27]Okazaki T Tanaka Y Nishio R Mitsuiye T Mizoguchi A Wang J Ishida M Hiai H Matsumori A Minato N Honjo T Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice Nat Med 2003 9 1477 14595408
  25. [28]Eriksson S Hellman J Pettersson K Autoantibodies against cardiac troponins N Engl J Med 2005 352 98 15635126
  26. [29]Mahrholdt H Sechtem U Noninvasive differentiation between active and healed myocarditis by cardiac magnetic resonance: are we there yet? JACC Cardiovasc Imaging 2009 2 139 19356546
  27. [30]Sosnovik DE Nahrendorf M Deliolanis N Novikov M Aikawa E Josephson L Rosenzweig A Weissleder R Ntziachristos V Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo Circulation 2007 115 1384 17339546
  28. [32]Lind M Bounias I Olsson M Gudbjornsdottir S Svensson AM Rosengren A Glycaemic control and incidence of heart failure in 20,985 patients with type 1 diabetes: an observational study Lancet 2011 378 140 21705065
  29. [33]Thaunat O Field AC Dai J Louedec L Patey N Bloch MF Mandet C Belair MF Bruneval P Meilhac O Bellon B Joly E Michel JB Nicoletti A Lymphoid neogenesis in chronic rejection: evidence for a local humoral alloimmune response Proc Natl Acad Sci U S A 2005 102 14723 16192350 PMC1253595
  30. [34]Libby P Inflammation in atherosclerosis Nature 2002 420 868 12490960
  31. [36]O'Garra A Gabrysova L Spits H Quantitative events determine the differentiation and function of helper T cells Nat Immunol 2011 12 288 21423225
  32. [37]Van Eyk JE Powers F Law W Larue C Hodges RS Solaro RJ Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation Circ Res 1998 82 261 9468197
  33. [38]Ganote CE Vander Heide RS Cytoskeletal lesions in anoxic myocardial injury. A conventional and high-voltage electron-microscopic and immunofluorescence study Am J Pathol 1987 129 327 3314531 PMC1899713
  34. [39]Frank D Kuhn C Katus HA Frey N The sarcomeric Z-disc: a nodal point in signalling and disease J Mol Med (Berl) 2006 84 446 16416311
  35. [40]Abbate A Bonanno E Mauriello A Bussani R Biondi-Zoccai GG Liuzzo G Leone AM Silvestri F Dobrina A Baldi F Pandolfi F Biasucci LM Baldi A Spagnoli LG Crea F Widespread myocardial inflammation and infarct-related artery patency Circulation 2004 110 46 15210601

Authors
Gottumukkala, R. V. S. R. K., Lv, H., Cornivelli, L., Wagers, A. J., Kwong, R. Y., Bronson, R., Stewart, G. C., Schulze, P. C., Chutkow, W., Wolpert, H. A., Lee, R. T., & Lipes, M. A.
Affiliations
  • Joslin Diabetes Center (US)
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
  • Gottumukkala, Raju V. S. R. K.
  • Lv, HuiJuan
  • Lipes, Myra A.
ORCID
Venue
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Published
2012-06-13
Volume
4
Issue
138
Pages
138ra80-138ra80
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
DOI
10.1126/scitranslmed.3003551
PMC
PMC4303259
OpenAlex
W2166848000
Cited by
76
References
56
Citations by year
2026: 4 · 2025: 9 · 2024: 2 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 4 · 2019: 9 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
FWCI
3.09
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL091157, HL077554, R01HL077554)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK36836, R01DK072090, P30DK036836)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
myocardial infarction, type 1 diabetes, cardiac autoimmunity, cardiac autoantibodies, cardiac myosin, T helper type 1 cells, myocarditis, NOD mice, infarct expansion, cardiac magnetic resonance imaging, antigen-specific immunotherapy
MeSH terms
Animals, Autoantibodies, Diabetes Mellitus, Type 1, Myocardial Infarction, Myocardium, Autoimmunity, Mice

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