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Cited by 272Epilepsy research and treatmentVirus-based gene therapy researchNeuroscience and Neuropharmacology Research

Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy

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Wykes, Robert C., Heeroma, Joost H., Mantoan, Laura, Zheng, Kaiyu, MacDonald, Douglas C., Deisseroth, Karl, Hashemi, Kevan S., Walker, Matthew C. +2 more·2012·Science Translational Medicine
DOI 10.1126/scitranslmed.3004190PMC PMC3605784
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Abstract

Light-activated gene therapy acutely suppresses seizures, and gene therapy with a potassium channel prevents epileptogenesis and treats established epilepsy in a rodent model.

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References 58 · Cited by 272

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Authors
Wykes, R. C., Heeroma, J. H., Mantoan, L., Zheng, K., MacDonald, D. C., Deisseroth, K., Hashemi, K. S., Walker, M. C., Schorge, S., & Kullmann, D. M.
Affiliations
  • UCL Queen Square Institute of Neurology (GB)
  • UCL Institute of Neurology, London WC1N 3BG, UK.
  • University College London (GB)
  • Stanford University (US)
  • Open Source Instruments Inc., Watertown, MA 02472, USA.
Corresponding author
  • Wykes, Robert C.
  • Heeroma, Joost H.
  • Walker, Matthew C.
  • Kullmann, Dimitri M.
ORCID
Venue
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Published
2012-11-21
Volume
4
Issue
161
Pages
161ra152-161ra152
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
DOI
10.1126/scitranslmed.3004190
PMC
PMC3605784
OpenAlex
W2134079336
Cited by
272
References
58
Citations by year
2026: 10 · 2025: 16 · 2024: 20 · 2023: 17 · 2022: 15 · 2021: 17 · 2020: 19 · 2019: 20 · 2018: 17 · 2017: 24 · 2016: 11 · 2015: 30 · 2014: 31 · 2013: 21 · 2012: 4
FWCI
19.65
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Wellcome Trust (086882, 089924, 095580)
  • Action Medical Research
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
gene therapy, optogenetics, halorhodopsin, Kv1.1 potassium channel, lentiviral vectors, pyramidal neurons, intrinsic excitability, epileptiform activity, seizure suppression, drug-resistant epilepsy, rodent epilepsy models
MeSH terms
Animals, Disease Models, Animal, Electroencephalography, Epilepsies, Partial, Male, Neurons, Tetanus Toxin, Genetic Therapy, Lentivirus, Rats, Sprague-Dawley, Pyramidal Cells, Neocortex, Rats, Kv1.1 Potassium Channel, Optogenetics

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