An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

Langley, Raymond J.; Tsalik, Ephraim L.; Velkinburgh, Jennifer C. van; Glickman, Seth W.; Rice, Brandon J.; Wang, Chunping; Chen, Bo; Carin, Lawrence; Suarez, Arturo; Mohney, Robert P.; Freeman, Debra H.; Wang, Mu; You, Jinsam; Wulff, Jacob; Thompson, J. Will; Moseley, M. Arthur; Reisinger, Stephanie; Edmonds, Brian T.; Grinnell, Brian; Nelson, David R.; Dinwiddie, Darrell L.; Miller, Neil A.; Saunders, Carol J.; Soden, Sarah S.; Rogers, Angela J.; Gazourian, Lee; Fredenburgh, Laura E.; Massaro, Anthony F.; Baron, Rebecca M.; Choi, Augustine M. K.; Corey, G. Ralph; Ginsburg, Geoffrey S.; Cairns, Charles B.; Otero, Ronny M.; Fowler, Vance G.; Rivers, Emanuel P.; Woods, Christopher W.; Kingsmore, Stephen F.

doi:10.1126/scitranslmed.3005893

Cited by 507

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

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Langley, Raymond J., Tsalik, Ephraim L., Velkinburgh, Jennifer C. van, Glickman, Seth W., Rice, Brandon J., Wang, Chunping, Chen, Bo, Carin, Lawrence, Suarez, Arturo, Mohney, Robert P., Freeman, Debra H., Wang, Mu, You, Jinsam, Wulff, Jacob, Thompson, J. Will, Moseley, M. Arthur, Reisinger, Stephanie, Edmonds, Brian T., Grinnell, Brian, Nelson, David R., Dinwiddie, Darrell L., Miller, Neil A., Saunders, Carol J., Soden, Sarah S., Rogers, Angela J., Gazourian, Lee, Fredenburgh, Laura E., Massaro, Anthony F., Baron, Rebecca M., Choi, Augustine M. K., Corey, G. Ralph, Ginsburg, Geoffrey S., Cairns, Charles B., Otero, Ronny M., Fowler, Vance G., Rivers, Emanuel P., Woods, Christopher W., Kingsmore, Stephen F.·2013·Science Translational Medicine

DOI 10.1126/scitranslmed.3005893

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Abstract

A molecular signature, derived from integrated analysis of clinical data, the metabolome, and the proteome in prospective human studies, improved the prediction of death in patients with sepsis, potentially identifying a subset of patients who merit intensive treatment.

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Authors: Langley, R. J., Tsalik, E. L., Velkinburgh, J. C. V., Glickman, S. W., Rice, B. J., Wang, C., Chen, B., Carin, L., Suarez, A., Mohney, R. P., Freeman, D. H., Wang, M., You, J., Wulff, J., Thompson, J. W., Moseley, M. A., Reisinger, S., Edmonds, B. T., Grinnell, B., Nelson, D. R., Dinwiddie, D. L., Miller, N. A., Saunders, C. J., Soden, S. S., Rogers, A. J., Gazourian, L., Fredenburgh, L. E., Massaro, A. F., Baron, R. M., Choi, A. M. K., Corey, G. R., Ginsburg, G. S., Cairns, C. B., Otero, R. M., Fowler, V. G., Rivers, E. P., Woods, C. W., & Kingsmore, S. F.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-07-24
Volume: 5
Issue: 195
Pages: 195ra95-195ra95
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3005893
OpenAlex: W2141151213
Cited by: 507
References: 94
FWCI: 20.11
Type: journal article
Language: en
Open access: green

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This page: CoChat. (2026). Citation check: An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis. https://app.cochat.ai/papers/10.1126/scitranslmed.3005893
The paper: Langley, R. J., Tsalik, E. L., Velkinburgh, J. C. V., Glickman, S. W., Rice, B. J., Wang, C., Chen, B., Carin, L., Suarez, A., Mohney, R. P., Freeman, D. H., Wang, M., You, J., Wulff, J., Thompson, J. W., Moseley, M. A., Reisinger, S., Edmonds, B. T., Grinnell, B., . . . Kingsmore, S. F. (2013). An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.3005893

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An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

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