Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis
Open accessAbstract
Genome-scale transcriptomic profiling of peripheral blood mononuclear cells from patients with idiopathic pulmonary fibrosis reveals that decreased expression of CD28 , ICOS , LCK , and ITK predicts mortality.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A PBMC transcriptional signature characterized by reduced expression of T cell regulatory genes related to the immune checkpoint CTLA-4 is associated with reduced event-free survival in IPF.
“transcriptional profiling of PBMCs found that a signature characterized by reduced expression of T cell regulatory genes related to the immune checkpoint CTLA-4 was associated with reduced event free survival (128)”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [128]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 45 · Cited by 325
Research works printed but not linked: 1
- [44]http://stke.sciencemag.org/
- Authors
- Herazo-Maya, J. D., Noth, I., Duncan, S. R., Kim, S., Ma, S.-F., Tseng, G. C., Feingold, E., Juan-Guardela, B. M., Richards, T. J., Lussier, Y., Huang, Y., Vij, R., Lindell, K. O., Xue, J., Gibson, K. F., Shapiro, S. D., Garcia, J. G. N., & Kaminski, N.
- Affiliations
- Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
- University of Chicago (US)
- University of Pittsburgh (US)
- Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
- Yale University (US)
- University of Illinois Chicago (US)
- Corresponding author
- Noth, Imre
- Duncan, Steven R.
- Kaminski, Naftali
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2013-10-02
- Volume
- 5
- Issue
- 205
- Pages
- 205ra136-205ra136
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4175518
- OpenAlex
- W2160906692
- Cited by
- 325
- References
- 45
- Citations by year
- 2026: 10 · 2025: 23 · 2024: 42 · 2023: 45 · 2022: 18 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 28 · 2017: 33 · 2016: 23 · 2015: 25 · 2014: 24 · 2013: 5
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hl073241-04, 5p50hl084932-05, UL1TR000005)
- National Heart, Lung, and Blood Institute (U01HL105371, HL98050, R01 HL073241, R01HL095397, U10HL080513, HL-0894932, P50-HL-084932, HL080513, U01HL108642, HL108642, P50HL107172, HL073241, P01HL098050, RC2HL101740, HL105371, HL095397, HL101740, HL107172)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- idiopathic pulmonary fibrosis, peripheral blood mononuclear cells, gene expression signatures, transplant-free survival, prognostic factors, CD28, ICOS, Lck, ITK, T cell costimulation, CD4+CD28- T cells, lung transplantation, mortality prediction, patient prioritization
- MeSH terms
- Humans, Leukocytes, Mononuclear, Reproducibility of Results, Cohort Studies, Signal Transduction, Biomarkers, CD4 Antigens, Cluster Analysis, Treatment Outcome, CD28 Antigens, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Idiopathic Pulmonary Fibrosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
