Cited by 399Pain Management and Placebo EffectMigraine and Headache StudiesAcupuncture Treatment Research Studies

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Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks

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Kam-Hansen, Slavenka, Jakubowski, Moshe, Kelley, John M., Kirsch, Irving, Hoaglin, David C., Kaptchuk, Ted J., Burstein, Rami·2014·Science Translational Medicine

DOI 10.1126/scitranslmed.3006175PMC PMC4005597

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Abstract

In 459 migraine attacks, information provided to patients (from negative to neutral to positive) modified placebo and medication outcomes in a progressive fashion.

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Effects of prefrontal transcranial direct current stimulation on open-label placebo responses
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“Research has demonstrated that placebos can achieve substantial ef ﬁ cacy in some clinical contexts, and similar processes may be at play here (Kam-Hansen et al., 2014).”
Starting strong: A descending analgesic dosing scheme enhances pain relief compared to a conventional ascending dosing schemePreprint
Mintah, M., Daunizeau, J., & Tinnermann, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.10.758177

Authors: Kam-Hansen, S., Jakubowski, M., Kelley, J. M., Kirsch, I., Hoaglin, D. C., Kaptchuk, T. J., & Burstein, R.
Affiliations: Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Beth Israel Deaconess Medical Center (US)
IC Independent Consulting (Australia) (AU)
Corresponding author: Kaptchuk, Ted J.
Burstein, Rami
ORCID: Jakubowski, Moshe
Kelley, John M.
Kirsch, Irving
Hoaglin, David C.
Kaptchuk, Ted J.
Burstein, Rami
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-01-08
Volume: 6
Issue: 218
Pages: 218ra5-218ra5
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3006175
PMC: PMC4005597
OpenAlex: W2169836118
Cited by: 399
References: 22
Citations by year: 2026: 11 · 2025: 26 · 2024: 21 · 2023: 26 · 2022: 28 · 2021: 38 · 2020: 47 · 2019: 38 · 2018: 42 · 2017: 36 · 2016: 27 · 2015: 29 · 2014: 29
FWCI: 22.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS069847, R37NS079678)
National Center for Complementary and Integrative Health (K24AT004095)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
Keywords: episodic migraine, placebo effect, drug labeling, rizatriptan, patient information, analgesia
MeSH terms: Drug Labeling, Humans, Migraine Disorders, Pain Measurement, Placebos, Triazoles, Tryptamines, Treatment Outcome, Endpoint Determination

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Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks

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