Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems
Open accessAbstract
Diet has a strong influence on the intestinal microbiota in both humans and animal models. It is well established that microbial colonization is required for normal development of the immune system and that specific microbial constituents prompt the differentiation or expansion of certain immune cell subsets. Nonetheless, it has been unclear how profoundly diet might shape the primate immune system or how durable the influence might be. We show that breast-fed and bottle-fed infant rhesus macaques develop markedly different immune systems, which remain different 6 months after weaning when the animals begin receiving identical diets. In particular, breast-fed infants develop robust populations of memory T cells as well as T helper 17 (TH17) cells within the memory pool, whereas bottle-fed infants do not. These findings may partly explain the variation in human susceptibility to conditions with an immune basis, as well as the variable protection against certain infectious diseases.
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Breast-fed infant macaques had a significantly greater abundance of Prevotella spp. and arachidonic acid.
“breast-fed infants had a significantly greater abundance of Prevotella spp. and arachidonic acid.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Ardeshir et al., 2014
Human infants receiving greater amounts of arachidonic acid were at lower risk of contracting HIV from their HIV-positive mothers, and enhanced TH17 populations have been associated with reduced viral loads in simian immunodeficiency virus infection.
“human infants receiving greater amounts of arachidonic acid were at lower risk of contracting HIV from their HIV+ mothers, and enhanced TH17 populations have been associated with reduced viral loads associated with infection from simian immunodeficiency virus (Ardeshir et al., 2014).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Ardeshir et al., 2014
In infant rhesus macaques, breast-fed compared to formula-fed animals had greater microbiota community richness, evenness, and diversity, features positively correlated with TH1, cytotoxic T, and TH17 cells.
“Community richness, evenness and diversity was greater in the microbiota of breast-fed compared to formula-fed animals, features that were positively correlated with TH1, cytotoxic T, and TH17 cells.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Ardeshir et al., 2014
Prevotella spp. express phospholipase A2, which is able to release arachidonic acid from phospholipid membranes.
“Prevotella spp. express phospholipase A2 which is able to release arachidonic acid from phospholipid membranes.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Ardeshir et al., 2014
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References 67 · Cited by 134
Research works printed but not linked: 1
- [60]Lane DJ Nucleic Acid Techniques in Bacterial Systematics Stackebrandt E Goodfellow M Wiley New York, NY 1991 115 148
- Authors
- Ardeshir, A., Narayan, N. R., Méndez-Lagares, G., Lu, D., Rauch, M., Huang, Y., Van Rompay, K. K. A., Lynch, S. V., & Hartigan-O’Connor, D. J.
- Affiliations
- University of California, Davis (US)
- California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
- University of California, San Francisco (US)
- Corresponding author
- Ardeshir, Amir
- Narayan, Nicole R.
- Hartigan-O’Connor, Dennis J.
- Venue
- Science Translational Medicine
- Published
- 2014-09-03
- Volume
- 6
- Issue
- 252
- Pages
- 252ra120-252ra120
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4362692
- OpenAlex
- W2149300436
- Cited by
- 134
- References
- 67
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 23 · 2015: 13 · 2014: 2
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (P51OD011107)
- National Institute of Allergy and Infectious Diseases (K23AI081540)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- breast milk, infant formula, rhesus monkeys, gut microbiota, infant immune development, memory T cells, Th17 cells, diet and immunity, microbial colonization, weaning
- MeSH terms
- Animals, Bottle Feeding, Breast Feeding, Diet, Humans, Immune System, Macaca mulatta, Arachidonic Acid, Principal Component Analysis, Gastrointestinal Tract, Metabolomics, Th17 Cells, Microbiota
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