Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa
Abstract
Epidermolysis bullosa patient–specific iPSCs were generated from spontaneously corrected revertant keratinocytes for skin reconstitution.
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Revertant keratinocytes of a junctional epidermolysis bullosa patient with compound heterozygous COL17A1 mutations used an iPSC approach to generate genetically corrected keratinocytes.
“More recently, revertant keratinocytes of a junctional epidermolysis bullosa patient with compound heterozygous COL17A1 mutations used an iPSC approach to generate genetically corrected keratinocytes (155).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [155]
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References 42 · Cited by 123
- Authors
- Umegaki-Arao, N., Pasmooij, A. M. G., Itoh, M., Cerise, J. E., Guo, Z., Levy, B., Gostyński, A., Rothman, L. R., Jonkman, M. F., & Christiano, A. M.
- Affiliations
- Department of Dermatology, Columbia University, New York, NY 10032, USA.
- University Medical Center Groningen (NL)
- Jikei University School of Medicine (JP)
- Columbia University (US)
- Corresponding author
- Christiano, Angela M.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2014-11-26
- Volume
- 6
- Issue
- 264
- Pages
- 264ra164-264ra164
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2167266797
- Cited by
- 123
- References
- 42
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 7 · 2019: 16 · 2018: 22 · 2017: 13 · 2016: 14 · 2015: 9 · 2014: 4
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- induced pluripotent stem cells, epidermolysis bullosa, revertant mosaicism, COL17A1, collagen XVII, junctional epidermolysis bullosa, keratinocyte differentiation, gene therapy
- MeSH terms
- Collagen Type XVII, Animals, Autoantigens, Base Sequence, Cell Differentiation, Epidermolysis Bullosa, Humans, Mice, Nude, Molecular Sequence Data, Mosaicism, Skin, Transcription, Genetic, Keratinocytes, Gene Expression Profiling, Non-Fibrillar Collagens, Mice, Induced Pluripotent Stem Cells
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