Cited by 123Pluripotent Stem Cells ResearchSkin and Cellular Biology ResearchCRISPR and Genetic Engineering

Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa

Umegaki-Arao, Noriko, Pasmooij, Anna M. G., Itoh, Munenari, Cerise, Jane E., Guo, Zongyou, Levy, Brynn, Gostyński, Antoni, Rothman, Lisa R. +2 more·2014·Science Translational Medicine

Abstract

Epidermolysis bullosa patient–specific iPSCs were generated from spontaneously corrected revertant keratinocytes for skin reconstitution.

Integrity signals

Registry

Crossref · 10.1126/scitranslmed.3009342

Cites

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  • Revertant keratinocytes of a junctional epidermolysis bullosa patient with compound heterozygous COL17A1 mutations used an iPSC approach to generate genetically corrected keratinocytes.

    “More recently, revertant keratinocytes of a junctional epidermolysis bullosa patient with compound heterozygous COL17A1 mutations used an iPSC approach to generate genetically corrected keratinocytes (155).”

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References 42 · Cited by 123

Authors
Umegaki-Arao, N., Pasmooij, A. M. G., Itoh, M., Cerise, J. E., Guo, Z., Levy, B., Gostyński, A., Rothman, L. R., Jonkman, M. F., & Christiano, A. M.
Affiliations
  • Department of Dermatology, Columbia University, New York, NY 10032, USA.
  • University Medical Center Groningen (NL)
  • Jikei University School of Medicine (JP)
  • Columbia University (US)
Corresponding author
Christiano, Angela M.
Venue
Science Translational Medicine
Published
2014-11-26
Volume
6
Issue
264
Pages
264ra164-264ra164
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2167266797
Cited by
123
References
42
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 7 · 2019: 16 · 2018: 22 · 2017: 13 · 2016: 14 · 2015: 9 · 2014: 4
FWCI
5.46
Type
journal article
Language
en
Open access
closed
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Keywords
induced pluripotent stem cells, epidermolysis bullosa, revertant mosaicism, COL17A1, collagen XVII, junctional epidermolysis bullosa, keratinocyte differentiation, gene therapy
MeSH terms
Collagen Type XVII, Animals, Autoantigens, Base Sequence, Cell Differentiation, Epidermolysis Bullosa, Humans, Mice, Nude, Molecular Sequence Data, Mosaicism, Skin, Transcription, Genetic, Keratinocytes, Gene Expression Profiling, Non-Fibrillar Collagens, Mice, Induced Pluripotent Stem Cells

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