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An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors
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An implantable microdevice is demonstrated to release microdoses of multiple drugs into confined regions of tumors and allows for assessment of each drug’s efficacy to identify optimal therapy.
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“There have been recent advancements in this arena involving implantable devices, but these approaches are currently only compatible with solid tumors, and require tumors of a minimum size that are easily accessible30.”
From Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate (2016) · cites this paper as [30]
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Metadata
- Authors
- Jonas, O., Landry, H. M., Fuller, J. E., Santini, J. T., Baselga, J., Tepper, R. I., Cima, M. J., & Langer, R.
- Affiliations
- Koch Institute for Integrative Cancer Research At MIT (US)
- Kibur Medical Inc., 29 Newbury Street, Suite 301, Boston, MA 02116, USA.
- Memorial Sloan Kettering Cancer Center (US)
- The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- Venue
- Science Translational Medicine
- Published
- 2015-04-22
- Volume
- 7
- Issue
- 284
- Pages
- 284ra57-284ra57
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4825177
- OpenAlex
- W2161687028
- Cited by
- 189
- References
- 58
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 9 · 2023: 10 · 2022: 30 · 2021: 17 · 2020: 20 · 2019: 14 · 2018: 12 · 2017: 19 · 2016: 22 · 2015: 14
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- National Cancer Institute (R21-CA177391)
- Kibur Medical Inc.
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- implantable microdevices, anticancer drug response, tumor microenvironment, combination therapy, local drug delivery, predictive biomarkers, minimally invasive biopsy, tumor models, precision oncology, drug development
- MeSH terms
- Animals, Antineoplastic Agents, Biopsy, Calibration, Dose-Response Relationship, Drug, Doxorubicin, Drug Screening Assays, Antitumor, Humans, Neoplasms, Polyethylene Glycols, Polymers, Prognosis, Biomarkers, Tumor, Drug Delivery Systems, Drug Monitoring, Apoptosis, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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