Long-lasting stem cell–like memory CD8 + T cells with a naïve-like profile upon yellow fever vaccination
Open accessAbstract
The yellow fever vaccine induces a CD8 + T stem cell–like memory subset with a naïve-like profile that persists long term.
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The increased turnover of naive CD8+ T cells in later life comes from CD95+CD45RA+CD28+ cells that are reverted memory cells, memory stem cells, or extensively homeostatically proliferated cells resembling murine virtual memory.
“This increased turnover does not derive from truly naive cells, but from CD95+CD45RA+CD28+ T cells that represent reverted memory cells (Pulko et al., 2016), memory stem cells (Fuertes Marraco et al., 2015), or cells that have undergone extensive homeostatic proliferation reminiscent of murine virtual memory cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Fuertes Marraco et al., 2015
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References 49 · Cited by 206
- Authors
- Fuertes Marraco, S. A., Soneson, C., Cagnon, L., Gannon, P. O., Allard, M., Maillard, S. A., Montandon, N., Rufer, N., Waldvogel, S., Delorenzi, M., & Speiser, D. E.
- Affiliations
- Ludwig Cancer Center, University of Lausanne, Epalinges CH-1066, Switzerland.
- SIB Swiss Institute of Bioinformatics (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Service Vaudois de Transfusion Sanguine de la Croix Rouge, Epalinges CH-1066, Switzerland.
- Corresponding author
- Speiser, Daniel E.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-04-08
- Volume
- 7
- Issue
- 282
- Pages
- 282ra48-282ra48
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W1965247885
- Cited by
- 206
- References
- 49
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 14 · 2023: 20 · 2022: 26 · 2021: 21 · 2020: 14 · 2019: 15 · 2018: 16 · 2017: 16 · 2016: 18 · 2015: 11
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- green
- serval.unil.ch
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- Funders
- Ludwig Cancer Research Center
- Swiss National Science Foundation (310030_135553, 320030_152856, CRSII3_141879)
- Cancer Vaccine Collaborative
- Swiss Cancer League (02836-08-2011)
- Swiss State Secretariat for Education, Research and Innovation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- yellow fever vaccine, CD8+ T cells, stem cell-like memory T cells, long-term immune memory, vaccine-induced T cell responses, self-renewal, mRNA expression profiling, live attenuated virus vaccine, T cell differentiation
- MeSH terms
- Adolescent, Adult, Aged, Epitopes, Antigens, Viral, Homeostasis, Humans, Immunologic Memory, Middle Aged, Peptides, Phenotype, RNA, Messenger, Vaccination, Yellow Fever, Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Interleukin-15, Gene Expression Profiling, Yellow Fever Vaccine, Cell Proliferation, Young Adult
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